1. Articles from e. koch

    1-16 of 16
    1. Quality Assessment of Tympanoplasty by Means of Endoscopic Optical Coherence Tomography

      Quality Assessment of Tympanoplasty by Means of Endoscopic Optical Coherence Tomography

      Introduction: The endoscopic optical coherence tomography (eOCT) allows the direct, contactless representation and evaluation of the morphology and oscillation behaviour of the tympanic membrane and adjoining tympanic cavity content. After further development of the measuring technology, the eOCT will be able to be used in vivo for the assessment of tympanoplasty results. Materials and Methods: The eOCT was applied to 10 patients after a tympanoplasty with an intact ossicular chain and to 10 patients after a Type III tympanoplasty. The measurement data of the morphology – especially the thickness – and oscillation behaviour of the tympanic membrane and the prosthesis coupling to ...

      Read Full Article
    2. Endoscopic Optical Coherence Tomography in Diagnostics of Otosclerosis

      Endoscopic Optical Coherence Tomography in Diagnostics of Otosclerosis

      Introduction: Endoscopic Optical Coherence Tomography (eOCT) enables both high-resolution contact-free 3D-imaging of the tympanic membrane and spatial and frequency-resolved oscillation measurement via Doppler-OCT. Thus it is possible to detect causes of conduction hearing loss. In case of otosclerosis, changes in oscillation amplitude at the umbo had been showed via Laser-Doppler-Vibrometry. Material and Methods: The eOCT system utilizes a swept source laser with a wave length around 1300nm. Field-of-view and working distance are 10 mm. Sound stimulus was a Chirp in the frequency range between 0.5 and 5 kHz at 95 dB. Morphological and functional measurements were done on 12 ...

      Read Full Article
    3. A System for Clinical Use of Endoscopic Optical Coherence Tomography

      A System for Clinical Use of Endoscopic Optical Coherence Tomography

      Introduction: Optical Coherence Tomography (OCT) allows non-invasive high-resolution imaging of tissues. With a penetration depth of a few millimeters it's possible to image the tympanic membrane and the close-by part of the tympanum, e.g. for diagnostics of otitis media and middle ear effusion. In the field of in vivo examination there are difficulties in access to the human tympanic membrane due to the narrow and curved external ear canal. We report a compact endoscopic OCT system for use in clinical research. Methods: We use a 3,5 mm endoscopic GRIN lens for video endoscopy and OCT. OCT is ...

      Read Full Article
    4. Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      The development of protective ventilation strategies for patients suffering from life-threatening lung diseases and the promotion of numerical simulation of lung tissue mechanics requires detailed knowledge about the three-dimensional alveolar micro-structure, their dynamics and elastic properties. Subpleural lung tissue can be observed in animal models utilizing optical coherence tomography (OCT) with a high spatial resolution. We present four-dimensional high-speed OCT imaging of single alveoli as a suitable technique for the visualization of the temporal changes of the three-dimensional structure during the ventilation with a temporal resolution of 17 stacks per ventilation cycle. The acquired four-dimensional information allows a quantitative evaluation ...

      Read Full Article
    5. A hybrid imaging system for simultaneous ophthalmic optical coherence tomography and dual-channel fluorescence detection in small animal models

      A hybrid imaging system for simultaneous ophthalmic optical coherence tomography and dual-channel fluorescence detection in small animal models

      We present a novel hybrid system that allows simultaneous high-resolution spectral domain optical coherence tomography (OCT) in the near-infrared and single-photon excited fluorescence (SPEF) detection in the green and red visible wavelength range for non-invasive multimodal imaging of the retina in small in vivo animal models such as zebrafish.

      Read Full Article
    6. Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography

      Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography
      Topical corticosteroids are widely used to treat atopic dermatitis (AD), but their anti-inflammatory mode of action can be accompanied by several unwanted side effects including skin atrophy and telangiectasia. In this 8-week, investigator-blinded, intraindividual right-left comparison study with patients with mild-to-moderate AD, hydrocortisone 1% cream (HCT) was applied twice daily for 4 weeks on one side of forehead skin without clinical signs of AD and pimecrolimus 1% cream (PIM) on the other. Epidermal and dermal thickness were assessed by optical coherence tomography (OCT) and high frequency ultrasound respectively. Skin atrophy and telangiectasia were assessed by contact dermatoscopic photography (Dermaphot®). Treatment ...
      Read Full Article
    7. 4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography

      4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography
      In this feasibility study we present a method for 4D imaging of healthy and injured subpleural lung tissue in a mouse model. We used triggered swept source optical coherence tomography with an A-scan frequency of 20 kHz to image murine subpleural alveoli during the ventilation cycle. The data acquisition was gated to the pulmonary airway pressure to take one B-scan in each ventilation cycle for different pressure levels. The acquired B-scans were combined offline to one C-scan for each pressure level. Due to the high acquisition rate of the used optical coherence tomography system, we are also able to perform ...
      Read Full Article
    8. Analysis of Murine Vascular Function In Vivo by Optical Coherence Tomography in Response to High-fat Diet

      In this study, we demonstrate the application of optical coherence tomography (OCT) as a contactless imaging technique to analyze vasodynamics in small blood vessels in vivo. The transluminal OCT imaging of vessels avoids micro traumata in the endothelium and circumvents surgical intervention. It can be performed in the intact perfused vessel and provides a new method to measure vascular function and dynamics in vivo. The resolution of 10 μm and the velocity of image acquisition are adequate to detect differences in the inner diameter, the maximal velocity, or the time to half-maximal diameter change of small vessels. We applied this ...
      Read Full Article
    9. Phase-resolved Doppler Fourier Domain Optical Coherence Tomography in the in vivo mouse model

      Blood flow velocities within vasodynamic measurements in the in vivo mouse model were imaged by using phase-resolved Doppler Fourier Domain Optical Coherence Tomography with a spectrum read-out rate of 12 kHz. The high temporal resolution of the system is used to quantify the pulse from real-time cross-sectional images of the murine saphenous artery. The Doppler method was evaluated by imaging a 1% Intralipid emulsion flowing through a glass capillary with an inner diameter of approximately 320 um.
      Read Full Article
    10. Transverse and oblique motion effects in Fourier Domain Optical Coherence Tomography

      In this study we describe the effects on the interference signal caused by transverse and oblique motion in spatially encoded Fourier Domain Optical Coherence Tomography (FD OCT). The artifacts caused by sample motion were analyzed theoretically and experimentally. The presented results supply an understanding of the SNR degradation caused by sample motion and demonstrates the importance of fast data acquisition in medical imaging.
      Read Full Article
    11. Velocity Analysis by Using Doppler Fourier Domain Optical Coherence Tomography with Variable Reference Length

      The measurement of blood flow is important in studying the pathophysiology and treatment of several diseases of blood vessels, like atherosclerosis. We present a method for flow measurement using resonant Doppler imaging with spectrometer based Fourier Domain Optical Coherence Tomography (FD-OCT). A modified Michelson interferometer, integrated in a 3D scanner head, with a variable reference length is used to determine velocities. Two methods are applied where cross-sectional images (B-scans) are taken while the reference arm for each depth scan (A-scan) has different states. In the 2- state method the reference mirror is moving axial towards respectively backwards in successive A-scans ...
      Read Full Article
    12. Fabrication of thin and flexible PDMS membranes for biomechanical test applications

      For continuous analysis of mechanical properties of soft biological tissues during mechanical stimulation we developed a bioreactor to apply controlled periodic deflection to a probe. The probe attached on an elastic membrane produces a counterpressure if a certain gas volume is applied to the pressure chamber under the membrane. The related counterpressure-volume relationship describes the mechanical properties of the membrane-probe combination. To improve the signal-to-noise ratio of measurements the use of highly flexible membranes is advantageous. We developed a specific adapter, attached securely to the central thread of a centrifuge, to fabricate silicone membranes on carrier rings with reproducible mechanical ...
      Read Full Article
    13. Three-dimensional Imaging of subpleural Alveoli by Fourier Domain Optical Coherence Tomography

      Understanding alveolar mechanics is essential to improve artificial ventilation strategies and hence minimize ventilator associated lung injury. The investigation of alveolar geometry changes during ventilation was performed by intravital microscopy (IVM) and 3D Fourier domain optical coherence tomography (3D-OCT) in an in-vivo mouse model and in isolated, perfused and ventilated rabbit lungs. Air pocket size of individual alveoli was quantified in the en-face view. For both imaging techniques, IVM and 3D-OCT, subpleural air-pocket size was positively correlated with the applied airway pressure (endinspiratory pressure or continuous positive airway pressure, respectively). No alveolar recruitment/derecruitment was observed. We conclude that in ...
      Read Full Article
    14. 3D-X-ray micro computed tomography and optical coherence tomography as methods for the localization of the germinal disk in the newly laid unincubated chicken egg

      The routine culling of the male offspring of hybrid layer type chickens is met with increasing public disapproval for both ethical and legal reasons. Until now practice-oriented methods for reliable sex diagnosis prior to hatch could not be developed. Molecular genetical analysis of blastodermic cells can be used for sex determination in unincubated eggs; however, knowledge of the precise localization of the germinal disc is crucial for the extraction of a carefully directed cell biopsy. In principle, 3D-X-ray micro computed tomography (3D-CT) has been proven a suitable method to localize the germinal disk in the unincubated egg without damaging the ...
      Read Full Article
    1-16 of 16
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (16 articles) Edmund Koch
    2. (15 articles) Dresden University of Technology
    3. (8 articles) Julia Walther
    4. (6 articles) Sven Meissner
    5. (4 articles) Lars Kirsten
    6. (2 articles) Henning Morawietz
    7. (2 articles) Maria Gaertner
    8. (2 articles) Nanyang Technological University
    9. (2 articles) Linbo Liu
    10. (1 articles) University of Freiburg
    11. (1 articles) Alexander Krüger
    12. (1 articles) University of Leipzig
    13. (1 articles) Harvard University
    14. (1 articles) University of Kent
    15. (1 articles) Kyushu University
    16. (1 articles) University of Miami
    17. (1 articles) Adrian G. Podoleanu
    18. (1 articles) Yoshiyasu Minami
    19. (1 articles) Sander R. Dubovy
    20. (1 articles) George M. Dobre
  3. Popular Articles

  4. Picture Gallery

    Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice PhD Student and Postdoctoral Associate Positions at the University of Massachusetts Early Detection of Microvascular Changes in Patients with Diabetes Mellitus without and with Diabetic Retinopathy: Comparison between Different Swept-Source OCT-A Instruments In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope A Simple Algorithm for Hard Exudate Detection in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Optical coherence tomography analysis of the recovery of the ellipsoid zone after macular hole surgery: 2-Year results Anterior Segment Applications of Optical Coherence Tomography Angiography Photothermal optical coherence tomography for investigation and imaging photothermal trapping of gold nano-rods in clear media and biological tissue Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography