1. Articles from Demetrios Vavvas

    1-3 of 3
    1. Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

      Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization
      Purpose The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. Methods CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and gene delivery was evaluated by coupling the NP with a green fluorescing protein plasmid (NP-GFPg). Rhodamine labeling (Rd-NP) was used to localize NP in choroidal flatmounts. Rd-NP-GFPg particles were injected intravenously on weeks 1, 2, or 3. In the treatment arm, rats received NP containing a ...
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    2. In-vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography

      In-vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography
      Purpose. To describe the in-vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT) Methods. Laser photocoagulation was applied to the mouse fundus using a 532 nm diode-laser (100,150 and 200 mW, 100 μm diameter, 0.1 sec duration). SD-OCT examination was performed immediately after laser application, and at day 3, 5, 7, 14, 21 and 28 after laser. Fluorescein angiography (FA) was performed at day 5, 7, 14 and 28. Acquired SD-OCT images were analyzed to describe morphologic features, measure CNV size and retinal thickness, and assess the frequency of lesions resulting ...
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    1-3 of 3
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    1. (3 articles) Massachusetts Eye and Ear Infirmary
    2. (3 articles) Harvard University
    3. (2 articles) Andrea Giani
    4. (1 articles) Stanford University
    5. (1 articles) Massachusetts Institute of Technology
    6. (1 articles) Topcon Medical Systems
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