1. Articles from Ningli Wang

    1-13 of 13
    1. Macular thickness and its associated factors in a Chinese rural adult population: the Handan Eye Study

      Macular thickness and its associated factors in a Chinese rural adult population: the Handan Eye Study

      Purpose To describe the normal macular thickness and assess its associations. Methods The Handan Eye Follow-up Study was conducted between 2012 and 2013. Macular thickness was scanned by spectral-domain optical coherence tomography (OCT). The built-in software generated a retinal thickness (RT) map, which was divided into three regions (central, internal and external regions) and nine quadrants (one in central and four in internal and external regions each). Results For 5394 subjects in the Handan Eye Follow-up Study, 4793 received OCT examination, 2946 of whom (accounting for 61.46% of the total subjects, mean age 58.91±10.95, 55.6 ...

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    2. Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study

      Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study

      Purpose To examine the normative profile of retinal nerve fibre layer (RNFL) thickness and ocular parameters based on spectral-domain optical coherence tomography (SD-OCT) and its associations with related parameters among the Chinese population. Methods This population-based cohort Handan Eye Study (HES) recruited participants aged≥30 years. All subjects underwent a standardised ophthalmic examination. Peripapillary RNFL thickness was obtained using SD-OCT. Mixed linear models were adopted to evaluate the correlation of RNFL thickness with ocular parameters as well as systemic factors. R V.3.6.1 software was used for statistical analysis. Results 3509 subjects (7024 eyes) with the average age ...

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    3. Imaging collector channel entrance with a new intraocular micro-probe swept-source optical coherence tomography

      Imaging collector channel entrance with a new intraocular micro-probe swept-source optical coherence tomography

      Purpose To describe the use of a newly developed side-viewing catheter probe to provide the cross-sectional images of collector channel entrance (CCE), achieved by swept-source optical coherence tomography (SS-OCT). Methods A side-viewing SS-OCT catheter probe was developed that has a core probe diameter of 0.15 mm and an outer diameter of 0.25 mm, for the purpose of imaging CCEs within eye globe. Cadaver eyes harvested from swine and human were used to demonstrate its feasibility. For porcine eyes, the probe imaged the CCE by accessing the region of the aqueous plexus (AP) as well as along the inner ...

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    4. Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction

      Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction

      Purpose: To evaluate optical coherence tomography meibography (OCT-M) in patients with and without obstructive meibomian gland dysfunction (MGD) and to determine the relationship between OCT-M and ocular surface clinical tests. Methods: Twenty-two patients with MGD and 16 control subjects were included. Each patient underwent an evaluation of ocular surface disease symptoms, lid margin abnormality score, lipid layer thickness evaluation, and meibomian gland (MG) morphological changes using noncontact infrared meibography and OCT-M. OCT-M scans were acquired in 4 different locations. OCT-M parameters including the MG length and width and palpebral conjunctival thickness were evaluated. Results: Within the OCT-M parameters, the mean ...

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    5. Retinal Nerve Fiber Layer Thickness in a Population of 12-year-old Children in Central China Measured by iVue-100 Optical Coherence Tomography

      Retinal Nerve Fiber Layer Thickness in a Population of 12-year-old Children in Central China Measured by iVue-100 Optical Coherence Tomography

      Purpose: To study the distribution of peripapillary retinal nerve fiber layer (RNFL) thickness in a population of 12-year-old children in central China using iVue-100 Spectral-domain optical coherence tomography (SD-OCT). Methods: 2105 of 12-year-old students from 4 randomly selected middle school in Anyang city participated in this study. Each child underwent ocular examinations including optical biometry, cycloplegic autorefraction and OCT (iVue-100). Glaucoma ONH scan was performed to measure the RNFL thickness. Only the children with signal strength higher than 45 were used for analyses. Multivariate analyses were performed to examine the distribution of RNFL with demographic (e.g., gender, age, body ...

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    6. Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study

      Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study

      Purpose. We evaluated repeatability and reproducibility of measurements of the retinal nerve fiber layer thickness (RNFLT), optic nerve head (ONH), and macular inner retinal layer (MIRL) by RTVue spectral-domain optical coherence tomography (OCT) in normal Rhesus monkeys. Methods. The experimental study included 15 adult Rhesus macaque monkeys. RNFLT, ONH parameters (area of disc, cup, and rim; volume of cup and rim; and cup-to-disc ratios), and MIRL thickness were imaged at three separate examinations within one month. Each eye was imaged three times at the first examination, and once at each of the two following examinations. We determined the intra-session and ...

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    7. Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys

      Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys

      Purpose. To evaluate repeatability and reproducibility of measurements of the retinal nerve fiber layer thickness (RNFLT), optic nerve head (ONH) and macular inner retinal layer (MIRL) by spectral-domain optical coherence tomography (OCT) (RTVue) in normal Rhesus monkeys. Method. The experimental study included 15 adult rhesus macaque monkeys. RNFLT, ONH parameters (area of disc, cup and rim; volume of cup and rim; cup/disc ratios) and MIRL thickness were imaged at three separate examinations within one month. Each eye was imaged three times at the first examination, and once at each of the two following examinations. We determined the intra-session and ...

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    8. Narrow- and Open-Angle Measurements With Anterior-Segment Optical Coherence Tomography and Pentacam™

      Narrow- and Open-Angle Measurements With Anterior-Segment Optical Coherence Tomography and Pentacam™

      BACKGROUND AND OBJECTIVETo assess the agreement of the Pentacam (Oculus, Wetzlar, Germany) and anterior-segment optical coherence tomography (AS-OCT) in measuring open and narrow angles.PATIENTS AND METHODSProspective observational case series in which 39 healthy normal subjects (39 eyes) and 25 patients with narrow angles (37 eyes) were enrolled between May and September 2008. The anterior chamber measurements were performed by AS-OCT and the Pentacam.RESULTSThere was no significant difference in the open-angle measurements between the Pentacam and AS-OCT (P > .05). However, in patients with narrow angles, the average values of nasal and temporal anterior chamber angles taken by the Pentacam ...

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    9. Comparative study of anterior segment measurement with Pentacam and anterior segment optical coherence tomography

      Comparative study of anterior segment measurement with Pentacam and anterior segment optical coherence tomography

      Objective: To evaluate the repeatability of central corneal thickness (CCT), anterior chamber volume (ACV), and central anterior chamber depth (CACD) measurements obtained using a Pentacam rotating Scheimpflug camera, and to examine their agreement with measurements obtained using an anterior segment optical coherence tomography (AS-OCT) imaging system.Design: Observational cross-sectional study.Participants: Fifty eyes from 50 healthy subjects were recruited.Methods: CCT, CACD, and ACV were measured. Subjects were re-examined twice within a week of the first measurements. Intrasession and intersession within-subject SD (Sw), precision (1.96 × Sw), coefficient of variation (CVw: 100 × Sw / overall mean), and intraclass correlation coefficient (ICC ...

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    10. Anterior Segment Optical Coherence Tomography Measurement of LASIK Flaps: Femtosecond Laser vs Microkeratome

      Anterior Segment Optical Coherence Tomography Measurement of LASIK Flaps: Femtosecond Laser vs Microkeratome

      In a series of 72 patients, a LASIK flap was made in one eye with the AMO IntraLase FS60 and in the other eye with the Moria M2 microkeratome and postoperative thickness patterns were measured with the Visante OCT in 20 locations in each eye. In the femtosecond laser group, the average deviation of flap thickness from intended was 5.54 µm, in the microkeratome eyes it was 10.28 µm, with a greater standard deviation for the Moria M2 and more uniformity of thickness across the flap for the IntraLase FS60.

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    11. Comparison of two retinal nerve fiber layer thickness measurement patterns of RTvue optical coherence tomography

      Comparison of two retinal nerve fiber layer thickness measurement patterns of RTvue optical coherence tomography
      Background: To evaluate the agreement and repeatability between operator-dependent centering and automatic centering RNFL thickness measurement patterns (RNFL3.45 and NHM4) of RTvue Optical Coherence Tomography in normal and glaucomatous eyes. Design: Cross-sectional observational study Participants: A total of 153 eyes from 149 normal subjects and subjects with glaucoma were analyzed. Methods: The RNFL thickness was measured using RNFL3.45 and NHM4 3 times on the same day to determine the repeatability and agreement between the two scan patterns. Main outcome measures: Student's paired t testing, intra-class correlation coefficient (ICC), coefficient of variation (CV), test-retest viability, Pearson's correlation ...
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    12. Evaluation of optic nerve head and retinal nerve fiber layer in early and advance glaucoma using frequency-domain optical coherence tomography

      Background Recent research has suggested that structural significant damage in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) may precede visual field loss. Optical coherence tomography (OCT) has become an important tool which has contributed to earlier and more accurate diagnosis of glaucoma over the past decade. RTVue OCT was the first frequency-domain OCT (FD-OCT) device to offer comprehensive glaucoma analysis including an RNFL thickness map and optic disc morphology. The aim of this study was to evaluate and compare the performance of FD-OCT for the detection of early and advanced glaucoma from normal eyes. Methods This ...

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    13. Dark Room Provocative Test and Extent of Angle Closure: An Anterior Segment OCT Study

      Purpose: To clarify the risk parameters measured by anterior segment optical coherence tomography (AS-OCT) for elevated intraocular pressures (IOP) provoked by the darkroom test and to provide recommendations for its clinical usage.Methods: Subjects aged >40 years and whose peripheral anterior chambers were =8 mm Hg after the test. Statistical analyses included: (1) the difference in parameters between positive and negative eyes; (2) the association between posttest IOP and the parameters; and (3) the difference in parameters between the 2 eyes in subjects with the asymmetric results.Results: A total of 70 subjects were recruited. ACD (P=0.022), NCA ...

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    1-13 of 13
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    Comparison of two retinal nerve fiber layer thickness measurement patterns of RTvue optical coherence tomography Comparative study of anterior segment measurement with Pentacam and anterior segment optical coherence tomography Narrow- and Open-Angle Measurements With Anterior-Segment Optical Coherence Tomography and Pentacam™ Anterior Segment Optical Coherence Tomography Measurement of LASIK Flaps: Femtosecond Laser vs Microkeratome Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study Retinal Nerve Fiber Layer Thickness in a Population of 12-year-old Children in Central China Measured by iVue-100 Optical Coherence Tomography Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction Postdoctoral Fellows/Research Scientists at University of Washington, Seattle Perimeter Medical Imaging AI Announces Publication of Peer-Reviewed Journal Article Validating Potential Use of Wide-Field Optical Coherence Tomography (WF-OCT) in Head and Neck Surgeries Association of retinal thickness and microvasculature with cognitive performance and brain volumes in elderly adults A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography