1. Articles from david s. greenfield

    1-18 of 18
    1. Detecting Glaucoma Progression Using Guided Progression Analysis with Optical Coherence Tomography and Visual Field Assessment in Eyes Classified by International Classification of Disease Severity Codes

      Detecting Glaucoma Progression Using Guided Progression Analysis with Optical Coherence Tomography and Visual Field Assessment in Eyes Classified by International Classification of Disease Severity Codes

      Purpose To compare the detection and rates of progressive retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) loss with spectral domain optical coherence tomography (SDOCT) and visual field (VF) loss using Guided Progression Analysis (GPA, Carl Zeiss Meditec, Dublin, CA) in glaucomatous eyes classified using International Classification of Disease diagnosis codes (ICD). Design Retrospective cohort study. Participants Glaucoma patients with at least 3 years of follow-up and a minimum of 4 SDOCT and 5 reliable VF exams. Methods Glaucoma severity was classified using ICD-10- diagnosis codes. Rates of RNFL, macular GCIPL and VF loss were calculated ...

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    2. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

      Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

      Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment Method We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as a significant negative trend for either NFL or GCC. VF progression was reached if either the event or trend analysis reached significance. Result The analysis included 417 glaucoma suspect/pre-perimetric ...

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    3. Longitudinal and Cross-Sectional Analyses of Age and Intraocular Pressure Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness

      Longitudinal and Cross-Sectional Analyses of Age and Intraocular Pressure Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness

      Purpose : To study the effect of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and ganglion cell complex (GCC) thickness in normal eyes. Methods : We analyzed the data from subjects enrolled in the multi-center longitudinal Advanced Imaging for Glaucoma (AIG) Study (www.AIGStudy.net). The data included yearly visits from the normal subjects group in the AIGS study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of NFL and GCC three times on each visit. To adjust for the repeated measurements for the same subjects, mixed effect models were used to evaluate the longitudinal ...

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    4. Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis

      Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis

      Purpose: To report diagnostic accuracy of optical coherence tomography (OCT) disc variables using both time-domain (TD) and Fourier-domain (FD) OCT, and to improve the use of OCT disc variable measurements for glaucoma diagnosis through regression analyses that adjust for optic disc size and axial length-based magnification error. Design: Observational, cross-sectional. Participants: In total, 180 normal eyes of 112 participants and 180 eyes of 138 participants with perimetric glaucoma from the Advanced Imaging for Glaucoma Study. Methods: Diagnostic variables evaluated from TD-OCT and FD-OCT were: disc area, rim area, rim volume, optic nerve head volume, vertical cup-to-disc ratio (CDR), and horizontal ...

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    5. Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography

      Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography

      Purpose To predict the development of glaucomatous visual field (VF) defects using Fourier-domain optical coherence tomography (FD-OCT) measurements at baseline visit. Design Multi-center longitudinal observational study. Glaucoma suspects and pre-perimetric glaucoma participants in the Advanced Imaging for Glaucoma Study. Methods The optic disc, the peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) were imaged with FD-OCT VF was assessed every 6 months. Conversion to perimetric glaucoma was defined by VF pattern standard deviation (PSD) or glaucoma hemifield test (GHT) outside normal limits on 3 consecutive tests. Hazard ratios were calculated with the Cox proportional hazard model ...

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    6. Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography

      Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography

      Aims To improve the diagnostic power for glaucoma by combining measurements of peripapillary nerve fibre layer (NFL), macular ganglion cell complex (GCC) and disc variables obtained with Fourier-domain optical coherence tomography (FD-OCT) into the glaucoma structural diagnostic index (GSDI). Methods In this observational, cross-sectional study of subjects from the Advanced Imaging of Glaucoma Study, GCC and NFL of healthy and perimetrical glaucoma subjects from four major academic referral centres of the Advanced Imaging of Glaucoma Study were mapped with the RTVue FD-OCT. Global loss volume and focal loss volume parameters were defined using NFL and GCC normative reference maps. Optimal ...

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    7. Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multi-center longitudinal observational cohort study Methods A total of 788 participants (1,329 eyes) were enrolled from three academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical exam, standard automated perimetry, and imaging with time-domain and Fourier-domain optical ...

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    8. Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study

      Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study

      Background/aims To examine the frequency of abnormal retinal nerve fibre layer thickness (RNFLT) and ganglion cell complex (GCC) measurements among healthy and glaucoma suspect and preperimetric glaucoma (GSPPG) eyes in a prospective longitudinal study. Methods Normal and GSPPG eyes with ≥18 months follow-up were included. Spectral-domain optical coherence tomography (SDOCT) was performed annually in normal and biannually in GSPPG eyes. One eye was randomly selected for inclusion. RNFLT and GCC parameters with p>5% were classified as ‘within normal limits (WNL)’ and p<1% were classified as ‘outside normal limits (ONL)’. Results 23 normal and 74 GSPPG eyes were ...

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    9. Combining Information From 3 Anatomic Regions in the Diagnosis of Glaucoma With Time-Domain Optical Coherence Tomography

      Combining Information From 3 Anatomic Regions in the Diagnosis of Glaucoma With Time-Domain Optical Coherence Tomography

      Purpose: To improve the diagnosis of glaucoma by combining time-domain optical coherence tomography (TD-OCT) measurements of the optic disc, circumpapillary retinal nerve fiber layer (RNFL), and macular retinal thickness. Patients and Methods: Ninety-six age-matched normal and 96 perimetric glaucoma participants were included in this observational, cross-sectional study. Or-logic, support vector machine, relevance vector machine, and linear discrimination function were used to analyze the performances of combined TD-OCT diagnostic variables. Results: The area under the receiver-operating curve (AROC) was used to evaluate the diagnostic accuracy and to compare the diagnostic performance of single and combined anatomic variables. The best RNFL thickness ...

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    10. Relationship among visual field, blood flow, and neural structure measurements in glaucoma

      Relationship among visual field, blood flow, and neural structure measurements in glaucoma

      Purpose:To determine the relationship among visual field, neural structural, and blood flow measurements in glaucoma. Methods:Case-control study. Forty-seven eyes of 42 patients with perimetric glaucoma were age-matched with 27 normal eyes of 27 patients. All patients underwent Doppler Fourier-domain optical coherence tomography to measure retinal blood flow and standard glaucoma evaluation with visual field testing and quantitative structural imaging. Linear regression analysis was performed to analyze the relationship among visual field, blood flow, and structure, after all variables were converted to logarithmic decibel scale. Results:Retinal blood flow was reduced in glaucoma eyes compared to normal eyes (p

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    11. The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral domain optical coherence tomography.

      The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral domain optical coherence tomography.
      Purpose: To evaluate the effect of race (African or European descent), age, disc area, and severity of disease on the diagnostic ability of spectral domain optical coherence tomography (SDOCT) imaging of the optic nerve, macula, and retinal nerve fiber layer (RNFL) in the detection of glaucomatous injury. Design: Cross-sectional observational study. Methods: Data from SDOCT images from 312 eyes from 167 subjects without ocular disease and 233 eyes from 163 patients with open angle glaucoma. Receiver operating characteristic (ROC) regression modeling technique was used to evaluate the influence of race on the diagnostic accuracies of the ONH, RNFL and macular ...
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    12. Detection of Progressive Retinal Nerve Fiber Layer Thickness Loss With Optical Coherence Tomography Using 4 Criteria for Functional Progression

      Detection of Progressive Retinal Nerve Fiber Layer Thickness Loss With Optical Coherence Tomography Using 4 Criteria for Functional Progression

      Purpose: To compare the rates of retinal nerve fiber layer (RNFL) thickness loss using optical coherence tomography (OCT) in progressing versus nonprogressing eyes using 4 methods to define functional progression. Methods: Normal and glaucomatous eyes with >=3 years of follow up were prospectively enrolled. Standard automated perimetry (Swedish Interactive Threshold Algorithm Standard 24-2) and OCT (Stratus OCT, Carl Zeiss Meditec, Dublin, CA) imaging were performed every 6 months in glaucomatous eyes. OCT imaging was performed annually in normal eyes. Functional progression was determined using early manifest glaucoma trial criterion, visual field index (VFI), Progressor software, and the 3-omitting method. Results ...

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    13. Quantification of Change in Axonal Birefringence Following Surgical Reduction in Intraocular Pressure

      Quantification of Change in Axonal Birefringence Following Surgical Reduction in Intraocular Pressure
      BACKGROUND AND OBJECTIVE The purpose of this study was to examine the hypothesis that retinal nerve fiber layer (RNFL) birefringence increases following surgical reduction of intraocular pressure (IOP). PATIENTS AND METHODS Twenty-six glaucomatous eyes requiring trabeculectomy or drainage implant were enrolled. Optical coherence tomography (OCT), scanning laser polarimetry (SLP), and IOP measurements were performed preoperatively and 3 months postoperatively. The OCT and SLP images were aligned using a new algorithm that aligns the vessels in an OCT image to those in the corresponding SLP reflectance image. The SLP retardance values at the location of the OCT scan circle were then ...
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    14. Topographic Differences in the Age-related Changes in the Retinal Nerve Fiber Layer of Normal Eyes Measured by Stratus Optical Coherence Tomography

      Topographic Differences in the Age-related Changes in the Retinal Nerve Fiber Layer of Normal Eyes Measured by Stratus Optical Coherence Tomography
      Purpose: To determine whether there are regional differences in the age-related changes in peripapillary retinal nerve fiber layer (RNFL) thickness as measured by time-domain optical coherence tomography (OCT). Methods: Fast peripapillary RNFL scans obtained with the Stratus time-domain OCT with nominal diameter of 3.46-mm centered on the optic disc were carried out on 425 normal participants over a wide age range. One eye was randomly selected for scanning or analysis. Average RNFL-, clock hour-, and quadrant-specific rates of RNFL thickness change were calculated and compared. Results: The 425 study participants ranged in age from 18 to 85 years with ...
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    15. Three-dimensional High-speed Optical Coherence Tomography for Diagnosis of Hypotony Maculopathy After Glaucoma Filtration Surgery

      Purpose: To describe the clinical findings of hypotony maculopathy using 3-dimensional (3D) topography maps reconstructed from spectral domain optical coherence tomography (SD-OCT) imaging, and compare SD-OCT with time domain OCT (TD-OCT) for hypotony maculopathy diagnosis. Methods: This was an observational noncomparative case series comprising 7 patients with hypotony maculopathy after trabeculectomy with mitomycin-C. All patients underwent consecutive imaging with TD-OCT (Stratus OCT) and SD-OCT using various high-resolution instruments. 3-D surface maps obtained using SD-OCT were compared with linear scans obtained using TD-OCT. Results: Two of 7 eyes had minimally detectable folds with TD-OCT imaging in the vertical axis. Five eyes ...
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    16. Optic Nerve Head (ONH) Topographic Analysis by Stratus OCT in Normal Subjects: Correlation to Disc Size, Age, and Ethnicity

      Purpose: To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age. Methods: Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity. Results: Two hundred and twelve ...
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    17. Diagnostic Ability of Fourier-Domain vs Time-Domain Optical Coherence Tomography for Glaucoma Detection

      Purpose To compare retinal nerve fiber layer (RNFL) thickness assessments and the discriminating ability of Fourier-domain optical coherence tomography (FD-OCT) with that of time-domain optical coherence tomography (TD-OCT) for glaucoma detection. Design Prospective, nonrandomized, observational cohort study. Methods Normal and glaucomatous eyes underwent complete examination, standard automated perimetry, optic disc photography, TD-OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA), and FD-OCT (RTVue; Optovue Inc, Fremont, California, USA). One eye per subject was enrolled. Two consecutive scans were acquired using a 3.46-mm diameter scan with TD-OCT and a 3.45-mm diameter scan with FD-OCT. For each of 5 RNFL ...
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    18. Combining Nerve Fiber Layer Parameters to Optimize Glaucoma Diagnosis with Optical Coherence Tomography

      Purpose To identify the best combination of Stratus optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness parameters for the detection of glaucoma. Design Observational cross-sectional study. Participants Eighty-nine age-matched normal and perimetric glaucoma participants enrolled in the Advanced Imaging for Glaucoma Study. Methods The Zeiss Stratus OCT system was used to obtain the circumpapillary RNFL thickness in both eyes of each participant. Right and left eye clock-hour data are analyzed together, assuming mirror-image symmetry. The RNFL diagnostic parameters were combined using either or-logic or and-logic approaches. Main Outcome Measures Area under the receiver operating characteristic curve (AROC), sensitivity ...
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    1-18 of 18
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    Topographic Differences in the Age-related Changes in the Retinal Nerve Fiber Layer of Normal Eyes Measured by Stratus Optical Coherence Tomography Quantification of Change in Axonal Birefringence Following Surgical Reduction in Intraocular Pressure The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral domain optical coherence tomography. Relationship among visual field, blood flow, and neural structure measurements in glaucoma Combining Information From 3 Anatomic Regions in the Diagnosis of Glaucoma With Time-Domain Optical Coherence Tomography Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography Expert consensus published on use of imaging to guide heart attack treatment Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies ‘Primum non nocere’ aortic dissection involving ostium of right coronary artery diagnosed by optical coherence tomography Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players Research Scientist for Optical Diagnostic at Carestream Dental Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent