1. Articles from mitsumasa ohyanagi

    1-10 of 10
    1. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Objectives This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). Background The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA is unknown. Methods IVUS and OCT examinations identified focal plaques in 165 coronary arteries from 60 autopsy hearts. A total of 685 pairs of images of OCT and IVUS were compared with histology. By OCT, a TCFA was defined as a signal-poor region with diffuse borders and cap thickness <65 μm. By IVUS, a TCFA was defined by ...

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    2. Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography

      Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography

      Although previous optical coherence tomography (OCT) studies reported that restenosis tissue after implantation of a drug-eluting stent (DES) was composed of a variety of cells, the clinical significance of morphologic characteristics for in-stent neointimal tissue as assessed by OCT has not been clarified. We experienced a patient with stable angina who underwent percutaneous coronary intervention with a 2.5 × 18-mm DES implantation 6 months before the OCT examination. OCT imaging showed a mild intimal hyperplasia (39 % neointimal hyperplasia) with eccentric, heterogeneous tissue, predominantly of low signal intensity. Seventeen months after the initial procedure, OCT revealed a significant increase in percent ...

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    3. Intracoronary Imaging for Detecting Vulnerable Plaque

      Intracoronary Imaging for Detecting Vulnerable Plaque

      It is now generally recognized that acute coronary syndromes most commonly result from disruption of thin-cap fibroatheroma (TCFA), which is characterized by a large necrotic core with an overlying thin-fibrous cap measuring <65μm. Recent advances in intracoronary imaging modalities have significantly improved the ability to detect TCFA in vivo. Intravascular ultrasound (IVUS) is perhaps the most promising modality that has been used more than 15 years to evaluate atherosclerotic plaque. IVUS has revealed a lot of the clinical evidence regarding vulnerable plaque detection in live humans. Recently, by analyzing the IVUS acoustic signal before demodulation and scan conversion, IVUS ...

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    4. Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Aims: The main cause of acute myocardial infarction (AMI) is the disruption of a thin-cap fibroatheroma (TCFA) and subsequent thrombosis. Mortality increases in diabetic patients due to cardiovascular events; there may be differences in the vulnerable plaques between diabetic and non-diabetic patients. We used optical coherence tomography (OCT) to assess the incidence of vulnerable plaques in diabetic patients with AMI. Methods and results: OCT was performed in all three major coronary arteries of 70 AMI patients: 48 non-diabetic and 22 diabetic patients. The OCT criterion for TCFA was the presence of both a lipid-rich plaque composition and a fibrotic cap ...

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    5. Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation

      Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation

      Background Zotarolimus-eluting stents (ZES) have a higher rate of neointimal coverage than the first-generation drug-eluting stents on optical coherence tomography (OCT). Objective To determine whether neointimal coverage of stent struts detected by OCT can be used as a surrogate for endothelial function after ZES implantation. Design Cross-sectional observational study. Setting Three months after ZES implantation. Patients and methods OCT was performed in 20 patients with a ZES at 3 months after stent implantation to evaluate strut coverage. Endothelium-dependent coronary vasomotion was estimated by infusing incremental doses of acetylcholine into the coronary ostium. The vascular response was measured in the 10 ...

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    6. OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      Objectives We evaluated the geographic distribution of thin-cap fibroatheromas (TCFAs) in the coronary arteries using optical coherence tomography (OCT), a high-resolution imaging modality. Background Plaque rupture is the most frequent cause of acute myocardial infarction (AMI). It has been recognized that TCFA is the primary plaque type at the site of plaque rupture. Methods We performed 3-vessel OCT examinations in 55 patients: 35 AMI and 20 stable angina pectoris patients. The criteria for TCFA in an OCT image was a lipid-rich plaque with fibrotic cap thickness <65 µm. The distance between each TCFA location and the respective coronary artery ostium ...

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    7. Effect of Atorvastatin on the Stability of Thin-cap Fibroatheroma: A Three-Vessel Optical Coherence Tomography and Intravascular Ultrasound Study

      Background: It is well known that administration of statins for patients with acute myocardial infarction is effective for secondary prevention of cardiovascular events. It is generally assumed that effects of statins would result from their effects on atherosclerotic lesions including stabilization of plaques, but effects of statins on plaque vulnerability have not been fully elucidated. Therefore, we evaluated the impact of atorvastatin on the fibrous cap thickness of thin-cap fibroatheroma (TCFA), which is recognized as precursor lesion of plaque rupture, using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in vivo. Methods: OCT and IVUS examinations were performed in all ...

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    8. Coronary Plaque Characteristics of Thin-cap Fibroatheroma: An Intravascular Ultrasound and Optical Coherence Tomography Study

      Background: Previous pathologic studies reported that the main mechanisms of acute coronary syndrome (ACS) are atherosclerotic plaque ruptures followed by thrombus formation. Therefore it is clinically important to identify plaques that are prone to rupture, known as thin-cap fibroatheroma (TCFA). The aim of this study is to evaluate plaque characteristics of TCFA using optical coherence tomography (OCT) in vivo. Methods: After the successful treatment of culprit lesions, OCT and intravascular ultrasound (IVUS) examinations were attempted prospectively using motorized pullback in all 3 major coronary arteries for 41 ACS and 42 stable angina pectoris (SAP) patients. In 78 patients, 303 moderate ...
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    9. Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study

      Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study

      (A) A 90% stenosis observed in the middle left anterior descending artery in patients with stable angina pectoris (arrow). (B) Lipid-rich plaque (L) covered by thin fibrous cap (63.3 µm) (arrowheads) observed in the target lesion of a patient with stable angina pectoris. (C) Lipid-rich plaque (L) covered by thin fibrous cap (arrowheads) detected in the noninfarct-related lesion of an acute myocardial infarction patient. (D) Magnification of (C). The thickness of the fibrous cap that existed betw

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    1-10 of 10
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    1. (9 articles) Mitsumasa Ohyanagi
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    Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study Intracoronary Imaging for Detecting Vulnerable Plaque Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study Long-Term Arterial Remodeling After Bioresorbable Scaffold Implantation 4-Year Follow-up of Quantitative Coronary Angiography, Histology and Optical Coherence Tomography Visualization of Bacterial Colonization and Cellular Layers in a Gut-on-a-Chip System Using Optical Coherence Tomography Optical Coherence Tomography Measurements as Potential Imaging Biomarkers for Parkinson's Disease: A Systematic Review and Meta-analysis Use of ultra-wide field retinal imaging and optical coherence tomography angiography in the diagnosis of incomplete Susac syndrome NinePoint Medical, Inc. filed a voluntary petition for relief under Chapter 11 of the United States Bankruptcy Code