Articles from James G. Fujimoto

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  1. Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second

    Explore Article opticsinfobase.org (Sep 3 2010) Ophthalmology , Tunable Sources

    Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second We demonstrate ultrahigh speed swept source/Fourier domain ophthalmic OCT imaging using a short cavity swept laser at 100,000 - 400,000 axial scan rates. Several design configurations illustrate tradeoffs in imaging speed, sensitivity, axial resolution, and imaging depth. Variable rate A/D optical clocking is used to acquire linear-in-k OCT fringe data at 100kHz axial scan rate with 5.3um axial resolution in tissue. Fixed rate sampling at 1 GSPS achieves a 7.5mm imaging range in tissue with 6.0um axial resolution at 100kHz axial scan rate. A 200kHz axial scan rate with 5.3um axial resolution over 4mm imaging range is achieved by buffering ... (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   David Huang   Alex E. Cable

  2. Choroidal Thickness in Normal Eyes Measured Using Cirrus HD Optical Coherence Tomography

    Explore Article American Journal of Ophthalmology (Jun 28 2010) Ophthalmology

    Choroidal Thickness in Normal Eyes Measured Using Cirrus HD Optical Coherence Tomography Purpose To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). Design Retrospective, observational case series. Methods Thirty-four eyes (34 subjects), with no retinal or choroidal disease, underwent high-definition raster scanning using SD-OCT with frame enhancement software. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-μm intervals up to 2500 μm temporal and nasal to the fovea. The central 1-mm area of the choroid was also measured, along with foveal thickness of the retina. All measurements were performed by 2 independent observers. Statistical analysis was ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Jay S. Duker

  3. Features of Sub-Epithelial Glandular Structures on Three-Dimensional Endoscopic Optical Coherence Tomography (3D-EOCT) After Endoscopic Mucosal Ablation

    Explore Article Gastrointestinal Endoscopy (Mar 31 2010) Gastroenterology

    Abstracts submitted to ASGE 2010. Endoscopic mucosal ablative therapies are becoming accepted as a treatment for Barrett's esophagus (BE) with high-grade dysplasia. Radiofrequency ablation (RFA) has been shown to be effective in achieving broad and superficial BE ablation and replacement with normal-appearing squamous epithelium. Endoscopic optical coherence tomography (EOCT) is an imaging technique that uniquely allows visualization of sub-surface structures. The new three-dimensional EOCT (3D-EOCT) provides both cross-sectional and en face images of examined structures. 3D-EOCT may represent a novel method for post-ablation BE surveillance by revealing different glandular structures underneath the post-ablative surface epithelium. (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Joseph M. Schmitt   Desmond C. Adler

  4. Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography (Book)

    Explore Article Slack Books (Mar 10 2010) Ophthalmology , Textbooks

    Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography (Book) Fourier-Domain optical coherence tomography (OCT) is the latest technology available to provide high-speed, high-resolution imaging of the cornea, anterior chamber angle, macula and optic nerve head. Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography (WW 141 I31 2010) by first author Dr. David Huang of Doheny Eye Institute and Drs. Jay S. Duker, James G. Fujimoto, Bruno Lumbroso, Joel S. Schuman, and Robert N. Weinreb covers up-to-date OCT technology and diagnostic software of the RTVue. Topics covered include: (Read Full Article)

    Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

  5. Ultrahigh-speed volumetric ophthalmic OCT imaging at 800nm and 1050nm

    Explore Article SPIE Digital Library (Mar 2 2010) Ophthalmology , Tunable Sources

    Ultrahigh-speed volumetric ophthalmic OCT imaging at 800nm and 1050nm The performance and imaging characteristics of ultrahigh speed ophthalmic optical coherence tomography (OCT) are investigated. In vivo imaging results are obtained at 850nm and 1050nm using different configurations of spectral and swept source / Fourier domain OCT. A spectral / Fourier domain instrument using a high speed CMOS linescan camera with SLD light source centered at 850nm achieves speeds of ~91,000 axial scans per second with ~3µm axial resolution in tissue. A spectral / Fourier domain instrument using an InGaAs linescan camera with SLD light source centered at 1050nm achieves ~47,000 axial scans per second with ~7µm resolution in tissue. ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   Thorlabs   Iwona Gorczyńska

  6. Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy

    Explore Article SPIE Digital Library (Mar 2 2010) Microscopy

    Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex vivo imaging of upper and lower gastrointestinal tract tissues, to establish correlations between OCM imaging and histology, and to provide a baseline for future endoscopic studies. Co-registered OCM and OCT imaging were performed on fresh surgical specimens and endoscopic biopsy specimens, and images were correlated with histology. Imaging was performed at 1.06-µm wavelength with <2-µm transverse and <4-µm axial resolution for OCM, and at 14-µm transverse and <3-µm axial ... (Read Full Article)

    Comment on Article Mentions:   Yu Chen   Aaron D. Aguirre   James G. Fujimoto

  7. Clinical Assessment of Mirror Artifacts in Spectral Domain Optical Coherence Tomography

    Explore Article iovs.org (Feb 26 2010) Ophthalmology

    Clinical Assessment of Mirror Artifacts in Spectral Domain Optical Coherence Tomography Purpose: To investigate the characteristics of a spectral domain Optical Coherence Tomography (SD OCT) image artifact known as the "mirror artifact", calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). Methods: Cirrus HD-OCT Macular Cube 512x128 scans taken between January 2008 and February 2009 at the New England Eye Center were analyzed for the presence of mirror artifacts. Artifact severity was analyzed by the degree of segmentation breakdown that it causes on the macular map. A retrospective medical records review was conducted for patients with artifacts and for a ... (Read Full Article)

    Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

  8. Integrated optical coherence tomography and optical coherence microscopy imaging of human pathology

    Explore Article SPIE Digital Library (Feb 24 2010) Microscopy

    Integrated optical coherence tomography and optical coherence microscopy imaging of human pathology Excisional biopsy is the current gold standard for disease diagnosis; however, it requires a relatively long processing time and it may also suffer from unacceptable false negative rates due to sampling errors. Optical coherence tomography (OCT) is a promising imaging technique that provide real-time, high resolution and three-dimensional (3D) images of tissue morphology. Optical coherence microscopy (OCM) is an extension of OCT, combining both the coherence gating and the confocal gating techniques. OCM imaging achieves cellular resolution with deeper imaging depth compared to confocal microscopy. An integrated OCT/OCM imaging system can provide co-registered multiscale imaging of tissue morphology. 3D-OCT provides ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Aaron D. Aguirre

  9. Endoscopic 3D-OCT reveals buried glands following radiofrequency ablation of Barrett's esophagus

    Explore Article SPIE Digital Library (Feb 24 2010) Gastroenterology

    Endoscopic 3D-OCT reveals buried glands following radiofrequency ablation of Barrett's esophagus Barrett's esophagus (BE) with high-grade dysplasia is generally treated by endoscopic mucosal resection or esophagectomy. Radiofrequency ablation (RFA) is a recent treatment that allows broad and superficial ablation for BE. Endoscopic three-dimensional optical coherence tomography (3D-OCT) is a volumetric imaging technique that is uniquely suited for follow-up surveillance of RFA treatment. 3D-OCT uses a thin fiberoptic imaging catheter placed down the working channel of a conventional endoscope. 3D-OCT enables en face and cross-sectional evaluation of the esophagus for detection of residual BE, neo-squamous mucosa, or buried BE glands. Patients who had undergone RFA treatment with the BARRX HALO90 system were ... (Read Full Article)

    Comment on Article Mentions:   LightLab Imaging   Massachusetts Institute of Technology   Joseph M. Schmitt

  10. Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

    Explore Article opticsinfobase.org (Feb 23 2010)

    Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells. (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Desmond C. Adler   Massachusetts Institute of Technology

  11. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy

    Explore Article SPIE Digital Library (Feb 22 2010) Microscopy

    Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. 34 thyroid gland specimens are imaged from 17 patients, covering a spectrum of pathology ranging from normal thyroid to benign disease/neoplasms (multinodular colloid goiter, Hashimoto's thyroiditis, and follicular adenoma) and malignant thyroid tumors (papillary carcinoma and medullary carcinoma). Imaging is performed using an integrated OCT and OCM system, with <4 µm axial resolution (OCT and OCM), and 14 µm (OCT) and <2 µm (OCM) transverse resolution. The system allows seamless switching between ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   Aaron D. Aguirre   Harvard University

  12. High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe

    Explore Article opticsinfobase.org (Feb 17 2010) Gastroenterology , Microscopy , Probes

    High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe ical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 µm axial and < 2 µm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro-optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto-focusing feature that enables precise, near real-time alignment of the confocal and coherence gates in tissue, allowing user-friendly ... (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Shu-Wei Huang   Aaron D. Aguirre

  13. Intact Retinal Tissue and Retinal Pigment Epithelium Identified Within A Coloboma By High-Speed, Ultrahigh-Resolution Optical Coherence Tomography

    Explore Article LWW Online (Feb 9 2010) Ophthalmology

    Purpose: The purpose of this study was to report on a posterior segment coloboma manifesting unusual morphology as determined by high-speed, ultrahigh-resolution optical coherence tomography imaging. Methods: A 47-year-old woman with bilateral colobomas was evaluated by fundus examination and high-speed, ultrahigh-resolution optical coherence tomography imaging. Results: Imaging with high-speed, ultrahigh-resolution optical coherence tomography showed intact retinal pigment epithelium within the posterior segment coloboma. Most of the retinal layers seemed to continue into the coloboma, although they exhibited slight attenuation. The external limiting membrane was clearly visible continuing within the coloboma, suggesting that Muller cells and the inner segments of the ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Vivek J. Srinivasan

  14. Quantitative cerebral blood flow with Optical Coherence Tomography

    Explore Article opticsinfobase.org (Jan 22 2010) Doppler

    Quantitative cerebral blood flow with Optical Coherence Tomography Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, David A. BoasAbsolute measurements of cerebral blood flow (CBF) are an important endpoint in studies of cerebral pathophysiology. Currently no accepted method exists for in vivo longitudinal monitoring of CBF with high resolution in rats and mice. Using three-dimensional Doppler Optical Coherence Tomography and ... [Opt. Express 18, 2477-2494 (2010)] (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Vivek J. Srinivasan   Iwona Gorczyńska

  15. COMPARISON OF SPECTRAL/FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY INSTRUMENTS FOR ASSESSMENT OF NORMAL MACULAR THICKNESS

    Explore Article LWW Online (Dec 3 2009) Ophthalmology

    Purpose: The purpose of this study was to report normal macular thickness measurements and assess reproducibility of retinal thickness measurements acquired by a time-domain optical coherence tomography (OCT) (Stratus, Carl Zeiss Meditec, Inc., Dublin, CA) and three commercially available spectral/Fourier domain OCT instruments (Cirrus HD-OCT, Carl Zeiss Meditec, Inc.; RTVue-100, Optovue, Inc., Fremont, CA; 3D OCT-1000, Topcon, Inc., Paramus, NJ). Methods: Forty randomly selected eyes of 40 normal, healthy volunteers were imaged. Subjects were scanned twice during one visit and a subset of 25 was scanned again within 8 weeks. Retinal thickness measurements were automatically generated by OCT software and ... (Read Full Article)

    Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

  16. Frequency comb swept lasers

    Explore Article opticsinfobase.org (Nov 6 2009) Tunable Sources

    Frequency comb swept lasers We demonstrate a frequency comb (FC) swept laser and a frequency comb Fourier domain mode locked (FC-FDML) laser for applications in optical coherence tomography (OCT). The fiber-based FC swept lasers operate at a sweep rate of 1kHz and 120kHz, respectively over a 135nm tuning range centered at 1310nm with average output powers of 50mW. A 25GHz free spectral range frequency comb filter in the swept lasers causes the lasers to generate a series of well defined frequency steps. The narrow bandwidth (0.015nm) of the frequency comb filter enables a ~- 1.2dB sensitivity roll off over ~3mm range, compared to conventional ... (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Desmond C. Adler   Massachusetts Institute of Technology

  17. Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

    Explore Article opticsinfobase.org (Oct 6 2009) Microscopy

    Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level. (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Vivek J. Srinivasan   Iwona Gorczyńska

  18. Retinal Nerve Fiber Layer Thickness Measurement Comparability between Time Domain Optical Coherence Tomography (OCT) and Spectral Domain OCT

    Explore Article iovs.org (Sep 8 2009) Ophthalmology

    Purpose: Time domain optical coherence tomography (TD-OCT) has been used commonly in clinical practice, producing a large inventory of circular scan data for retinal nerve fiber layer (RNFL) assessment. Spectral domain OCT (SD-OCT) produces three dimensional (3D) data volumes. The purpose of this study was to create a robust technique that makes TD-OCT circular scan RNFL thickness measurements comparable with those from 3D SD-OCT volumes. Methods: Eleven eyes of 11 healthy subjects and 7 eyes of 7 glaucoma subjects were enrolled. Each eye was scanned using 1 centered and 8 displaced TD-OCT scanning circles. One 3D SD-OCT cube scan was ... (Read Full Article)

    Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

  19. Ultrahigh speed spectral/Fourier domain OCT imaging in ophthalmology

    Explore Article SPIE Digital Library (Jul 13 2009) Ophthalmology

    Ultrahigh speed Spectral/Fourier domain ophthalmic OCT imaging at 70,000-312,500 axial scans per second is demonstrated using a high speed CMOS camera at 800 nm. Comparative imaging results of the fovea illustrate the performance tradeoffs between different imaging speeds and spectrometer configurations. Dense 3D volumetric acquisitions show minimal motion artifacts when acquired at 250,000 axial scans per second. The porous structure of the lamina cribrosa is shown in en face images extracted from a dense volumetric acquisition of the optical nerve head acquired at 106, 382 axial scans per second. Rapid repeated volume imaging (4D-OCT) shows blood flow in retinal capillaries. ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   Thorlabs   Alex E. Cable

  20. Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices

    Explore Article OphSource (Jul 8 2009) Ophthalmology

    Purpose: To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.Design: Prospective, noncomparative, noninterventional case series.Participants: Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008.Methods: Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512×128 (software version 3.0; Carl Zeiss Meditec, Inc., Dublin, CA), RTVue (E)MM5 and ... (Read Full Article)

    Comment on Article Mentions:   James G. Fujimoto   Optovue   Topcon Medical Systems

  21. Retinal Nerve Fiber Layer Thickness Measurement Reproducibility Improved with Spectral Domain Optical Coherence Tomography

    Explore Article BJO Online (May 6 2009) Ophthalmology

    Background/aims: To investigate retinal nerve fiber layer (RNFL) thickness measurement reproducibility using conventional time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT), and to evaluate two methods defining the optic nerve head (ONH) centering: centered each time (CET) vs. centered once (CO), in terms of RNFL thickness measurement variability on SD-OCT. Methods: Twenty-seven eyes (14 healthy subjects) had 3 circumpapillary scans with TD-OCT and 3 raster scans (three-dimensional or 3D image data) around ONH with SD-OCT. SD-OCT images were analyzed in two ways: 1) CET: ONH center was defined on each image separately, and 2) CO: ONH center was defined ... (Read Full Article)

    Comment on Article Mentions:   University of Pittsburgh   Richard A. Bilonick   Gadi Wollstein

  22. High-speed Ultrahigh Resolution Optical Coherence Tomography before and after Ranibizumab for Age-related Macular Degeneration

    Explore Article OphSource (Apr 30 2009) Ophthalmology

    Objective: To evaluate intraretinal anatomy in patients with exudative age-related macular degeneration (AMD) using high-speed ultrahigh resolution optical coherence tomography (hsUHR-OCT) before and 1 month after intravitreal injection of ranibizumab.Design: Retrospective case series.Participants: Twelve eyes of 12 patients.Methods: A broad bandwidth superluminescent diode laser light source and spectral/Fourier domain signal detection were used to create a prototype hsUHR-OCT instrument with 3.5 μm axial image resolution and approximately 25,000 lines/second acquisition speed. Twelve eyes of 12 patients with exudative AMD were imaged with hsUHR-OCT before and 1 month after intravitreal ranibizumab injection. High pixel density and raster-scanned 3-dimensional (3D) OCT data ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   University of Pittsburgh   James G. Fujimoto

  23. Effects of Age on Optical Coherence Tomography Measurements of Healthy Retinal Nerve Fiber Layer, Macula, and Optic Nerve Head

    Explore Article OphSource (Apr 22 2009) Ophthalmology

    Purpose: To determine the effects of age on global and sectoral peripapillary retinal nerve fiber layer (RNFL), macular thicknesses, and optic nerve head (ONH) parameters in healthy subjects using optical coherence tomography (OCT). Design: Retrospective, cross-sectional observational study. Participants: A total of 226 eyes from 124 healthy subjects were included. Methods: Healthy subjects were scanned using the Fast RNFL, Fast Macula, and Fast ONH scan patterns on a Stratus OCT (Carl Zeiss Meditec, Dublin, CA). All global and sectoral RNFL and macular parameters and global ONH parameters were modeled in terms of age using linear mixed effects models. Normalized slopes ... (Read Full Article)

    Comment on Article Mentions:   Larry Kagemann   Carl Zeiss Meditec   Gadi Wollstein

  24. Biomedical Optical Imaging (Book)

    Explore Article Oxford University Press (Apr 9 2009) Textbooks

    Biomedical Optical Imaging (Book) Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Daniel L. Farkas

  25. In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT

    Explore Article opticsinfobase.org (Mar 5 2009) Ophthalmology

    In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT Non-invasive methods of probing retinal function are of interest for the early detection of retinal disease. While retinal function is traditionally directly measured with the electroretinogram (ERG), recently functional optical imaging of the retina has been demonstrated. In this manuscript, stimulus-induced, intrinsic optical scattering changes in the human retina are measured in vivo with high-speed, ultrahigh resolution optical coherence tomography (OCT) operating at 50,000 axial scans per second and ~3.3 micron axial resolution. A stimulus and measurement protocol that enables measurement of functional OCT retinal signals is described. OCT signal changes in the photoreceptors are demonstrated. Two distinct responses having ... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Vivek J. Srinivasan

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