1. Articles from Robert P. Finger

    1-11 of 11
    1. Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography

      Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography

      Here, we investigate the extent to which re-implementing a previously published algorithm for OCT-based drusen quantification permits replicating the reported accuracy on an independent dataset. We refined that algorithm so that its accuracy is increased. Following a systematic literature search, an algorithm was selected based on its reported excellent results. Several steps were added to improve its accuracy. The replicated and refined algorithms were evaluated on an independent dataset with the same metrics as in the original publication. Accuracy of the refined algorithm (overlap ratio 36–52%) was significantly greater than the replicated one (overlap ratio 25–39%). In particular ...

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    2. Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis

      Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis

      Introduction For quantification of Optical Coherence Tomography Angiography (OCTA) images, Vessel Density (VD) and Vessel Skeleton Density (VSD) are well established parameters and different algorithms are in use for their calculation. However, comparability, reliability and ability to discriminate healthy and impaired macular perfusion of different algorithms are unclear, yet, of potential high clinical relevance. Hence, we assessed comparability and test-retest reliability of the most common approaches. Materials and methods Two consecutive 3×3mm OCTA en face images of the superficial and deep retinal layer were acquired with swept-source OCTA. VD and VSD were calculated with manual thresholding and six automated ...

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    3. Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease

      Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease

      The authors report a case of acute Vogt-Koyanagi-Harada syndrome with massively impaired perfusion in the Sattler's layer on optical coherence tomography angiography (OCTA). The hypoperfusion fully resolved during a period of 4 weeks and correlated well with hypofluorescent spots on indocyanine green angiography. This is the first time reduced perfusion in Sattler's layer has been observed on OCTA. This finding may aid further understanding of the pathology underlying VKH syndrome and indicates that evaluation of deeper choroidal layers like Sattler's layer may be of importance for disease monitoring and predicting prognosis in choroidal diseases.

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    4. Optical coherence tomography angiography in intermediate uveitis

      Optical coherence tomography angiography in intermediate uveitis

      Purpose To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A) Design Case-control study Methods Patients and age-matched controls were imaged with swept-source OCT-A (PLEX Elite 9000, Zeiss). Using ImageJ superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI) and fractal dimension (FD). Choriocapillaris layer was automatically graded for mean signal intensity, signal intensity standard deviation, kurtosis of signal intensity distribution and flow-signal-voids. Results Twentynine intermediate uveitis eyes and 30 control eyes were included. Both superficial and deep retinal layers showed ...

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    5. CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography

      CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography

      Optical coherence tomography (OCT) is used to diagnose and track progression of age-related macular degeneration (AMD). Drusen, which appear as bumps between Bruch’s membrane (BM) and the retinal pigment epithelium (RPE) layer, are among the most important biomarkers for staging AMD. In this work, we develop and compare three automated methods for Drusen segmentation based on the U-Net convolutional neural network architecture. By cross-validating on more than 50, 000 annotated images, we demonstrate that all three approaches achieve much better accuracy than a current state-of-the-art method. Highest accuracy is achieved when the CNN is trained to segment the BM ...

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    6. Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review

      Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review

      Purpose : To assess the quality of optical coherence tomography (OCT) grading algorithms for retinal biomarkers of age-related macular degeneration (AMD). Methods : Following a systematic review of the literature data on detection and quantification of AMD retinal biomarkers by available algorithms were extracted and descriptively synthesized. Algorithm quality was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies 2 checklist with a focus on accuracy against established reference standards and risk of bias. Results : Thirty five studies reporting computer-aided diagnosis (CAD) tools for qualitative analysis or algorithms for quantitative analysis were identified. Compared with manual assessment in ...

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    7. The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS)

      The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS)

      Purpose : To evaluate the impact of lens opacity on retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening (BMO) measurements. Methods : Fifty-nine randomly selected patients without any other relevant ocular pathology undergoing elective routine cataract surgery in two specialized eye clinics were enrolled. RNFLT, BMO area, and BMO minimum rim width (BMO-MRW) were assessed with the Heidelberg Engineering Spectralis OCT using the anatomical positioning system (APS) prior to and 1 day after cataract surgery using a ring scan at different eccentricities of the disc (3.5, 4.1 and 4.7 mm). Lens opacity was quantified using densitometry ...

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    8. Spectral Domain Optical Coherence Tomography in Adult-Onset Vitelliform Macular Dystrophy With Cuticular Drusen

      Spectral Domain Optical Coherence Tomography in Adult-Onset Vitelliform Macular Dystrophy With Cuticular Drusen
      Purpose: The purpose of this study was to investigate morphologic differences in a consecutive case series of patients suffering from adult-onset vitelliform macular dystrophy with cuticular drusen (CD) compared with another patient group with a vitelliform lesion only using high-resolution in vivo retinal imaging. Methods: Simultaneous spectral domain optical coherence tomography (870 nm, 40.000 A-scans per second) and confocal scanning laser ophthalmoscopy were performed in 6 patients (12 eyes) with adult-onset vitelliform macular dystrophy using a combined instrument (Spectralis HRA+OCT; Heidelberg Engineering). Results: Mean age was 69 years (59-82 years), and mean visual acuity was 20/80. The ...
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    9. Multimodal imaging including spectral domain OCT and confocal near infrared reflectance for characterisation of outer retinal pathology in pseudoxanthoma elasticum

      Purpose: To investigate the value of multimodal confocal scanning laser ophthalmoscopy (cSLO) for phenotyping fundus lesions in patients with pseudoxanthoma elasticum (PXE) and to correlate these findings with morphological alterations detected by spectral domain optical coherence tomography (SD-OCT). Methods: Imaging was performed with a combined and simultaneous SD-OCT-cSLO (SpectralisHRA-OCT, Heidelberg Engineering, Heidelberg, Germany). OCT scans were placed at locations of interest on near-infrared (NIR) reflectance, fundus autofluorescence (FAF) and fluorescein angiography (FA) images. The instrument allowed for exact topographic correlation of findings on OCT and cSLO images. Results: NIR reflectance imaging showed highest sensitivity to detect angioid streaks and peau ...
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    1-11 of 11
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    Spectral Domain Optical Coherence Tomography in Adult-Onset Vitelliform Macular Dystrophy With Cuticular Drusen Morphologic outer retinal abnormalities in white dot syndromes on spectral-domain optical coherence tomography The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS) Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography Optical coherence tomography angiography in intermediate uveitis Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease Comment on ‘Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography Health collaborations forged at CIIE begin to bear fruit Method for determining the topography of the cornea of an eye