1. Articles from mingguang he

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    1. Anterior Segment Parameters of Filipino-Americans Compared to Chinese-Americans and Caucasian Americans Using Anterior Segment Optical Coherence Tomography

      Anterior Segment Parameters of Filipino-Americans Compared to Chinese-Americans and Caucasian Americans Using Anterior Segment Optical Coherence Tomography

      Purpose : We compare anterior segment characteristics of Filipino- versus Chinese- and Caucasian-Americans to describe the differences in risk factors among each ethnic group. Methods : A cross-sectional study was conducted among Filipino, Chinese, and Caucasian subjects without glaucoma who underwent a standardized set of ocular examinations and anterior segment optical coherence tomography (Visante ASOCT) imaging. Zhongshan Angle Assessment Program (ZAAP) 4 was used for ASOCT image analysis. The following quantitative parameters wereobtained from ZAAP: (1) angle opening distance (AOD500, AOD750), angle recess area at 750 μm (ARA), and trabecular-iris space area at 500 and 750 μm (TISA500, TISA750); (2) iris parameters ...

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    2. Comparison of anterior segment optical coherence tomography parameters among Vietnamese, Chinese, and Caucasians

      Comparison of anterior segment optical coherence tomography parameters among Vietnamese, Chinese, and Caucasians

      Purpose To evaluate the difference in anterior segment optical coherence tomography (AS-OCT) parameters among ethnic Vietnamese, Chinese, and Caucasians Design Cross-sectional study Methods We prospectively recruited phakic non-glaucomatous participants (based on intraocular pressure <21 mmHg, normal optic nerve head and retinal nerve fiber, and cup-to-disc ratio <0.6) of three ethnic groups— Vietnamese, Chinese, and Caucasians. AS-OCT parameters including angle (angle opening distance, trabecular-iris space area, and angle recess area), iris (iris thickness, iris area, and iris curvature (Icurv)), and anterior chamber parameters (anterior chamber depth, width (ACW), area, and lens vault (LV)) were obtained. A linear regression model with ...

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      Mentions: Shan C. Lin UCSF
    3. Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography

      Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography

      Purpose : To assess the interdevice agreement between swept-source Fourier-domain and time-domain anterior segment optical coherence tomography (AS-OCT). Methods : Fifty-three eyes from 41 subjects underwent CASIA2 and Visante OCT imaging. One hundred eighty–degree axis images were measured with the built-in two-dimensional analysis software for the swept-source Fourier-domain AS-OCT (CASIA2) and a customized program for the time-domain AS-OCT (Visante OCT). In both devices, we examined the angle opening distance (AOD), trabecular iris space area (TISA), angle recess area (ARA), anterior chamber depth (ACD), anterior chamber width (ACW), and lens vault (LV). Bland-Altman plots and intraclass correlation (ICC) were performed. Orthogonal linear ...

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      Mentions: Shan C. Lin UCSF
    4. Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Background/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the macula with scanning lines analysed by two ophthalmologists to assess for the presence of 12 different posterior segment lesions. Per cent agreement for each lesion between the graders and quantitative ...

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    5. Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes

      Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes

      Purpose : To evaluate the features of extrafoveal retinoschisis (EFRS) in highly myopic eyes detected by swept-source optical coherence tomography (SS-OCT). Methods : In this retrospective case series, 89 eyes of 65 patients with high myopia and coexisting EFRS were included. The participants underwent a comprehensive ophthalmologic examination, including visual acuity, ocular biometry, refraction, and perimetry. Three-dimensional wide-field scans were obtained with SS-OCT, and en face images were reconstructed with custom software. En face OCT features of EFRS were determined by two ophthalmologists masked to clinical characteristics. The associations of EFRS subtypes with ocular biometry and other OCT changes were evaluated as ...

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    6. Comparison of Anterior Chamber Parameters in Patients With Plateau Iris Configuration and Pupillary Block Using ASOCT

      Comparison of Anterior Chamber Parameters in Patients With Plateau Iris Configuration and Pupillary Block Using ASOCT

      Purpose: To quantitatively analyze the anterior chamber parameters in patients with pupillary block (PB) and plateau iris configuration (PIC) using anterior segment optical coherence tomography (ASOCT). Patients and Methods: In this cross-sectional study, nonglaucomatous subjects consecutively recruited and a total of 212 eyes divided into 3 groups of PIC (31 eyes), PB (60 eyes), and open angles (121 eyes) based on gonioscopic and ultrasound biomicroscopy findings. All patients underwent ASOCT imaging and A-scan biometry of both eyes. Anterior chamber depth (ACD), anterior chamber area (ACA), iris thickness (IT), iris curvature, lens vault (LV), anterior vault, and angle parameters including angle ...

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    7. Effects of Valsalva Maneuver on Anterior Chamber Parameters and Choroidal Thickness in Healthy Chinese: An AS-OCT and SS-OCT Study

      Effects of Valsalva Maneuver on Anterior Chamber Parameters and Choroidal Thickness in Healthy Chinese: An AS-OCT and SS-OCT Study

      Purpose : This study concurrently evaluated the effects of the Valsalva maneuver (VM) on the anterior and posterior ocular biometric parameters in a healthy Chinese cohort. Methods : This prospective, cross-sectional study used anterior segment optical coherence tomography (AS-OCT) and swept-source optical coherence tomography (SS-OCT) to measure the anterior and posterior ocular biometric parameters before and during the VM. Sixty-three volunteers (126 eyes; 17 males and 46 females) were enrolled. The IOP, blood pressure (BP), and refractive error were recorded before and during a VM. Results : The mean IOP showed a statistically significant increase (from 13.86–14.25 mm Hg, P ...

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    8. Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes

      Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes

      Purpose : The purpose of this study is to compare anterior segment-optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure and acute primary angle closure (APAC) eyes. Methods : In this cross-sectional case series, a total of 134 patients with phacomorphic angle closure (28 eyes) or APAC (54 eyes), as well as normal control subjects (52 eyes), were enrolled. Patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth (ACD), anterior chamber area (ACA), iris thickness (IT), iris curvature, lens vault (LV), anterior vault (AV), and angle parameters including angle opening distance (AOD 500 and AOD750) and trabecular iris ...

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      Mentions: Shan C. Lin UCLA UCSF
    9. Anterior and Posterior Ocular Biometry in Healthy Chinese Subjects: Data Based on AS-OCT and SS-OCT

      Anterior and Posterior Ocular Biometry in Healthy Chinese Subjects: Data Based on AS-OCT and SS-OCT

      Background To measure the anterior and posterior ocular biometric characteristics concurrently and to determine the relationship between the iris and choroid in healthy Chinese subjects. Methods A total of 148 subjects (270 eyes) were enrolled in this cross-section study. The anterior and posterior ocular biometric characteristics were measured simultaneously by anterior segment optical coherence tomography (AS-OCT) and swept-source optical coherence tomography (SS-OCT). Results Compared with male eyes, female eyes had narrower anterior biometric parameters that presented with smaller anterior segment parameters [including anterior chamber depth (ACD), width (ACW), area (ACA), and volume (ACV); (all p<0.001)], narrower anterior chamber ...

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    10. Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Purpose:To describe anterior segment optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure (PMAC) eyes, mature cataract eyes and their fellow eyes, and identify those parameters that could be used to differentiate PMAC eyes from those with mature cataract and no PMAC. Methods:In this cross-sectional study a total of 33 PMAC subjects and 34 control patients with unilateral mature cataracts were enrolled. All patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth(ACD), anterior chamber area(ACA), iris thickness, iris curvature, lens vault(LV), and angle parameters including angle opening distance(AOD750) and trabecular ...

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    11. Assessment of laser induction of Bruch's membrane disruption in monkey by spectral-domain optical coherence tomography

      Assessment of laser induction of Bruch's membrane disruption in monkey by spectral-domain optical coherence tomography

      Purpose Laser-induced choroidal neovascularisation is a widely used model for age-related macular degeneration. The success rates of induction have been relatively low in large animals such as monkeys. Our study aimed to investigate the laser-induced damages to the Bruch's membrane of monkeys using the spectral-domain optical coherence tomography (OCT). Methods Laser photocoagulation was performed in the posterior and peripheral fundus of a rhesus monkey using a 532 nm laser. The lesions were examined by fundus photography and spectral-domain OCT immediately after the procedure. Fluorescein angiography was performed after 3 and 4 weeks in the animal to assess the development ...

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    12. Development of a Score and Probability Estimate for Detecting Angle Closure Based on Anterior Segment Optical Coherence Tomography

      Development of a Score and Probability Estimate for Detecting Angle Closure Based on Anterior Segment Optical Coherence Tomography

      Purpose To develop a score along with an estimated probability of disease for detecting angle closure based on anterior segment optical coherence tomography (AS OCT) imaging. Design Cross-sectional study. Methods A total of 2047 subjects 50 years of age and older were recruited from a community polyclinic in Singapore. All subjects underwent standardized ocular examination including gonioscopy and imaging by AS OCT (Carl Zeiss Meditec). Customized software (Zhongshan Angle Assessment Program) was used to measure AS OCT parameters. Complete data were available for 1368 subjects. Data from the right eyes were used for analysis. A stepwise logistic regression model with ...

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    13. Subgrouping of Primary Angle-Closure Suspects Based on Anterior Segment Optical Coherence Tomography Parameters

      Subgrouping of Primary Angle-Closure Suspects Based on Anterior Segment Optical Coherence Tomography Parameters

      Purpose To identify subgroups of primary angle-closure suspects (PACS) based on anterior segment optical coherence tomography (AS-OCT) and biometric parameters. Design Cross-sectional study. Participants We evaluated 243 PACS subjects in the primary group and 165 subjects in the validation group. Methods Participants underwent gonioscopy and AS-OCT (Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure AS-OCT parameters. An agglomerative hierarchical clustering method was first used to determine the optimum number of parameters to be included in the determination of subgroups. The best number of subgroups was then determined using Akaike Information Criterion ...

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    14. Anterior Segment Optical Coherence Tomography Parameters in Subtypes of Primary Angle Closure

      Anterior Segment Optical Coherence Tomography Parameters in Subtypes of Primary Angle Closure

      Purpose: To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with APAC. Methods: This was a prospective ASOCT study of 425 subjects with angle closure (176 PACS, 66 PAC, 125 PACG, and 58 APAC). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure ASOCT parameters, including angle opening distance (AOD750), trabecular-iris space area (TISA750), anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV ...

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    15. Relationship Between Intraocular Pressure and Angle Configuration: An Anterior Segment OCT Study

      Relationship Between Intraocular Pressure and Angle Configuration: An Anterior Segment OCT Study

      Purpose: To assess the relationship between intra-ocular pressure (IOP) and anterior chamber angle (ACA) configuration as assessed by gonioscopy and anterior segment optical coherence tomography (AS-OCT). Methods: 2045 subjects aged 50 years and over, recruited from a community clinic, underwent AS-OCT, Goldmann applanation tonometry, and gonioscopy. A quadrant was classified as closed on gonioscopy if the posterior trabecular meshwork could not be seen. A closed quadrant on AS-OCT was defined by the presence of any contact between the iris and angle wall anterior to the scleral spur. Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure AS-OCT ...

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    16. Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure

      Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure

      Objective: A recent study found that a combination of 6 anterior segment optical coherence tomography (ASOCT) parameters (anterior chamber area, volume, and width [ACA, ACV, ACW], lens vault [LV], iris thickness at 750 μm from the scleral spur, and iris cross-sectional area) explain >80% of the variability in angle width. The aim of this study was to evaluate classification algorithms based on ASOCT measurements for the detection of gonioscopic angle closure.Design: Cross-sectional study.Participants: We included 2047 subjects aged ≥50 years.Methods: Participants underwent gonioscopy and ASOCT (Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou ...

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    17. Determinants and Two-Year Change in Anterior Chamber Angle Width in a Chinese Population

      Determinants and Two-Year Change in Anterior Chamber Angle Width in a Chinese Population

      Objective: To study the population distribution and longitudinal changes in anterior chamber angle width and its determinants among Chinese adults.Design: Prospective cohort, population-based study.Participants: Persons aged 35 years or more residing in Guangzhou, China, who had not previously undergone incisional or laser eye surgery.Methods: In December 2008 and December 2010, all subjects underwent automated keratometry, and a random 50% sample had anterior segment optical coherence tomography with measurement of angle-opening distance at 500 μm (AOD500), angle recess area (ARA), iris thickness at 750 μm (IT750), iris curvature, pupil diameter, corneal thickness, anterior chamber width (ACW), lens vault ...

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    18. Correlation of anterior segment optical coherence tomography measurements with graft trephine diameter following descemet stripping automated endothelial keratoplasty

      Correlation of anterior segment optical coherence tomography measurements with graft trephine diameter following descemet stripping automated endothelial keratoplasty

      Background To assess repeatability of the Zhongshan Assessment Program (ZAP) software measurement of Anterior Segment Optical Coherence Tomography (ASOCT) images and correlate with graft trephine diameter following Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Methods Retrospectively evaluated interventional case series. 121 consecutive eyes undergoing DSAEK over a 26 month period underwent ASOCT imaging 1 month after their surgery. ASOCT images were processed using ZAP software which measured the graft and cornea parameters including anterior and posterior graft arc length and cord length, posterior cornea arc length (PCAL) and anterior chamber width. Results The graft measurements showed good repeatability on ASOCT using ...

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    19. Anterior Chamber Dimensions and Posterior Corneal Arc Length in Malay Eyes: An Anterior segment Optical Coherence Tomography Study

      Anterior Chamber Dimensions and Posterior Corneal Arc Length in Malay Eyes: An Anterior segment Optical Coherence Tomography Study

      Purpose: To provide normative data of corneal and anterior segment dimensions and a novel parameter, PCAL, in an adult Malay population. Methods: The current analysis is a sub-study of the Singapore Malay Eye Study (SiMES), a cross-sectional, population-based study of urban Malays aged 40-80 years. Subjects underwent ophthalmic and systemic examination, including imaging with anterior segment optical coherence tomography (AS-OCT). Ocular parameters were subsequently measured with the Zhongshan Assessment Program (ZAP): Anterior chamber depth (ACD), central corneal thickness (CCT), anterior and posterior corneal curvature (ACC and PCC), and posterior corneal arc length (PCAL), which is a novel parameter defined as ...

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    20. Comparison of anterior ocular biometry between optical low-coherence reflectometry and anterior segment optical coherence tomography in an adult Chinese population

      Comparison of anterior ocular biometry between optical low-coherence reflectometry and anterior segment optical coherence tomography in an adult Chinese population

      Purpose To evaluate the agreement between optical low-coherence reflectometry (OLCR) and anterior segment optical coherence tomography (AS-OCT) for biometry of the anterior segment. Setting State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Design Evaluation of diagnostic technology. Methods A series of OLCR (Lenstar LS 900) and AS-OCT measurements of the anterior segment were taken for consecutive subjects aged 35 years and older in a population-based study. The differences and correlations between the 2 methods of ocular biometry were assessed. Agreement was calculated as the 95% limits of agreement (LoA). Results The mean age of the ...

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    21. Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Purpose Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate changes in these parameters after laser peripheral iridotomy (LPI) in a cohort of primary angle-closure suspects (PACS). Design Prospective observational study. Participants and Controls A total of 176 PACS aged ≥50 years who underwent LPI in 1 eye. Methods We analyzed ASOCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from all subjects using customized software before and ...

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    22. Reproducibility of Cornea Measurements in Anterior Segment OCT images of Normal Eyes and Eyes with Bullous Keratopathy Analyzed with the Zhongshan Assessment Program (ZAP)

      Reproducibility of Cornea Measurements in Anterior Segment OCT images of Normal Eyes and Eyes with Bullous Keratopathy Analyzed with the Zhongshan Assessment Program (ZAP)

      Purpose: To determine the interobserver and intraobserver measurement reproducibility of cornea parameters of both normal eyes and eyes with bullous keratopathy obtained with the Zhongshan Assessment Program (ZAP, Guangzhou, China) on Anterior segment optical coherence tomography (AS-OCT, Visante; Carl Zeiss Meditec, Dublin, CA) images. Methods: Comparative study of 24 healthy volunteers and 25 subjects with bullous keratopathy (BK). AS-OCT images were independently analyzed by two examiners. Parameters examined: anterior chamber depth (ACD), central corneal thickness (CCT), posterior corneal curvature (PCC) and posterior corneal arc length (PCAL). Interobserver and intraobserver reproducibility of the above parameters was calculated in terms of limits ...

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    23. Biometry of the Cornea and Anterior Chamber in Chinese Eyes: an Anterior Segment Optical Coherence Tomography Study

      Purpose: To investigate the normative data of corneal and anterior segment biometric parameters in Chinese adults and their associations for use in preoperative assessment for corneal and anterior segment surgery. Methods: This cross-sectional, population based study included 750 subjects aged 50 years. The subjects underwent an ophthalmic examination including imaging using anterior segment optical coherence tomography (AS-OCT). Dimensions were subsequently measured with the Zhongshan Assessment Program (ZAP). We also include posterior corneal arc length (PCAL), a novel parameter defined as the arc distance between scleral spurs on the posterior border of the cornea. Correlations with age, gender, height, weight, body ...

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    24. Distinctive Findings in a Patient With Axenfeld–Rieger Syndrome Using High-Resolution AS-OCT

      Some distinct findings of a patient with Axenfeld-Rieger syndrome from the anterior chamber angle images by high-resolution anterior segment optical coherence tomography (AS-OCT) are described. The typical anterior segment anomalies of Axenfeld-Rieger syndrome, including iris atrophy, posterior embryotoxon, peripheral bridging tissue bands, trabecular meshwork elongation, and high insertion of the iris root into the posterior trabecular meshwork, can be visualized clearly on AS-OCT images. Specifically, the high-resolution mode of the AS-OCT program had improved performance in outlining finer structures such as the distinctive endothelial membrane covering the iris in Axenfeld-Rieger syndrome, which enabled better understanding of the pathophysiology in the ...
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    1-24 of 29 1 2 »
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