1. Articles from gijs van soest

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    1. Feature Of The Week 09/10/2017: Thermo-elastic Optical Coherence Tomography

      Feature Of The Week 09/10/2017: Thermo-elastic  Optical Coherence Tomography

      The conventional OCT image contrast is derived from elastic scattering, and shows the internal structure of the sample. The determination of the tissue type in OCT images usually depends on the interpretation by the image reader. More accurate tissue type contrast may be achieved by new OCT-based imaging modalities, with sensitivity to other physical parameters than scattering alone. Phase-sensitive OCT can detect tissue motion on nanometer-to- micrometer length scales using the phase of the OCT signal. Depending on the nature of the excitation, different functional images can be reconstructed: a mechanical stimulus yields images of tissue elasticity (optical coherence elastography ...

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    2. Thermo-elastic optical coherence tomography

      Thermo-elastic optical coherence tomography

      The absorption of nanosecond laser pulses induces rapid thermo-elastic deformation in tissue. A sub-micrometer scale displacement occurs within a few microseconds after the pulse arrival. In this Letter, we investigate the laser-induced thermo-elastic deformation using a 1.5 MHz phase-sensitive optical coherence tomography (OCT) system. A displacement image can be reconstructed, which enables a new modality of phase-sensitive OCT, called thermo-elastic OCT. An analysis of the results shows that the optical absorption is a dominating factor for the displacement. Thermo-elastic OCT is capable of visualizing inclusions that do not appear on the structural OCT image, providing additional tissue type information.

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    3. Intravascular imaging for characterization of coronary atherosclerosis

      Intravascular imaging for characterization of coronary atherosclerosis

      This short review surveys recent developments in coronary intravascular imaging technologies. We present an outline of the applications of intravascular imaging for guidance of percutaneous coronary interventions and imaging of atherosclerosis, along with emerging clinical evidence for use. Imaging of tissue composition is important for understanding the relation between the presence of a lesion and clinical sequelae. We describe the recent innovations to enable imaging of unstable atherosclerotic plaques, focusing on the emergence of experimental multimodal imaging technology.

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    4. A new technique for lipid core plaque detection by optical coherence tomography for prevention of peri-procedural myocardial infarction: A case report

      A new technique for lipid core plaque detection by optical coherence tomography for prevention of peri-procedural myocardial infarction: A case report

      Rationale: Percutaneous coronary intervention (PCI) provides effective revascularization of atherosclerotic coronary arteries but the invasive nature of treatment can result in complications. Patient concerns: A 53-year old man underwent coronary angiography due to chest pain with minimal ST-segment elevation in the inferior leads of the electrocardiogram. Diagnosis: We proceeded directly to coronary angiography and delineated a moderate stenosis with haziness in the mid right coronary artery (RCA). Interventions: Expert analysis of the pre-intervention OCT imaging demonstrated a large lipid core plaque (LCP), upstream of the culprit site, with minimal thrombus burden. Subsequent implantation of a bioresorbable vascular scaffold, protected with ...

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    5. EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging

      EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging

      Aims: Qualitative criteria for plaque tissue characterisation by OCT are well established, but quantitative methods lack systematic validation in vivo . High optical attenuation coefficient µ t has been associated with unstable plaque features, such as lipid core. The purpose of this study was to validate optical coherence tomography (OCT) attenuation imaging for tissue characterisation in vivo , specifically to detect lipid core in coronary atherosclerotic plaques, and to evaluate quantitatively the ability of OCT attenuation imaging to differentiate thin-cap (TCFA) and thick-cap fibroatheroma (FA). Methods and results: We prospectively enrolled 85 patients undergoing imaging of a native coronary segment by both OCT ...

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    6. Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

      Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

      Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and ...

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    7. Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

      Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of coronary artery pathologies and interventions (1) . In contrast to the cross-sectional view, longitudinal sections and 3-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements (2) . We developed Heartbeat OCT, a new OCT method that achieves up to 4,000 frames/s imaging speed for isotropically sampled volume datasets acquired within the diastolic phase of 1 cardiac cycle to restore 3D IV-OCT image fidelity. In this research letter, we present the first in vivo data acquired ...

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    8. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular ...

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    9. Safety of optical coherence tomography in daily practice: a comparison with intravascular ultrasound

      Safety of optical coherence tomography in daily practice: a comparison with intravascular ultrasound

      Aims Previous studies have reported the safety and feasibility of both time-domain optical coherence tomography (TD-OCT) and Fourier-domain OCT (FD-OCT) in highly selected patients and clinical settings. However, the generalizability of these data is limited, and data in unselected patient populations reflecting a routine cathlab practice are lacking. We compared safety of intracoronary FD-OCT imaging to intravascular ultrasound (IVUS) imaging in a large real-world series of consecutive patients who underwent invasive imaging during coronary catheterization in our centre. Methods and results This is a prospective, single-centre registry of patients scheduled for coronary angiography or intervention undergoing intracoronary imaging with FD-OCT ...

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    10. Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography

      Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography

      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of the coronary artery pathologies and interventions. In contrast to the cross-sectional view, longitudinal sections and three-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements. We developed Heartbeat OCT, a new OCT method that overcomes these issues. This study aims to demonstrate in vivo Heartbeat OCT in a preclinical setting, imaging eliminating cardiac motion artifacts, undersampling and non-uniform rotational distortion, to generate high-quality OCT volumes. Using a micro motor actuated catheter and a MHz sweep rate ...

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    11. Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography

      Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography

      Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called “Heartbeat OCT”, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s ...

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    12. A Micromotor Catheter for Intravascular Optical Coherence Tomography

      A Micromotor Catheter for Intravascular Optical Coherence Tomography

      We have developed a new form of intravascular optical coherence tomography (IV-OCT) that allows the extremely fast acquisition of high-resolution images of the coronary arteries. This process leads to much better image quality by eliminating cardiac motion artefacts and undersampling. It relies on a catheter that incorporates a synchronous micromotor with a diameter of 1.0 mm and a rotational speed of up to 5600 revolutions per second, enabling an IV-OCT frame rate of 5.6 kHz. This speed is matched by a wavelength-swept laser that generates up to 2.8 million image lines per second. With this setup, our ...

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    13. Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Objectives Fibrous cap thickness is the most critical component of plaque stability. Therefore, in vivo quantification of cap thickness could yield valuable information for estimating the risk of plaque rupture. In the context of preoperative planning and perioperative decision making, intracoronary optical coherence tomography imaging can provide a very detailed characterization of the arterial wall structure. However, visual interpretation of the images is laborious, subject to variability, and therefore not always sufficiently reliable for immediate decision of treatment. Methods A novel semiautomatic segmentation method to quantify coronary fibrous cap thickness in optical coherence tomography is introduced. To cope with the ...

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    14. OCT Assessment of the Long-Term Vascular Healing Response 5 Years After Everolimus-Eluting Bioresorbable Vascular Scaffold

      OCT Assessment of the Long-Term Vascular Healing Response 5 Years After Everolimus-Eluting Bioresorbable Vascular Scaffold

      Background Although recent observations suggest a favorable initial healing process of the everolimus-eluting bioresorbable vascular scaffold (BVS), little is known regarding long-term healing response. Objectives This study assessed the in vivo vascular healing response using optical coherence tomography (OCT) 5 years after elective first-in-man BVS implantation. Methods Of the 14 living patients enrolled in the Thoraxcenter Rotterdam cohort of the ABSORB A study, 8 patients underwent invasive follow-up, including OCT, 5 years after implantation. Advanced OCT image analysis included luminal morphometry, assessment of the adluminal signal-rich layer separating the lumen from other plaque components, visual and quantitative tissue characterization, and ...

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    15. Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation

      Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation

      Cardiovascular disease is associated with a high burden of mortality secondary to acute coronary events. Assessment for vulnerable plaque and an understanding of the etiology of stent failure by intravascular imaging may facilitate a greater understanding of the underlying processes responsible for adverse clinical outcomes and guide future therapy. This review focuses on the role of optical coherence tomography in tissue characterization and highlights future advances within the field providing potential enhancement of image interpretation.

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    16. Effect of temperature and fixation on the optical properties of atherosclerotic tissue: a validation study of an ex-vivo whole heart cadaveric model

      Effect of temperature and fixation on the optical properties of atherosclerotic tissue: a validation study of an ex-vivo whole heart cadaveric model

      Atherosclerotic plaque composition can be imaged using the optical attenuation coefficient derived from intravascular optical coherence tomography (OCT) data. The relation between optical properties and tissue type has been established on autopsy tissues. In this study, we validate an ex-vivo model for the effect of temperature and tissue fixation on optical parameters. We studied the optical attenuation of human coronary arteries at three temperatures, before and after formalin fixation. We developed an en-face longitudinal display of attenuation data of the OCT pullbacks. Using the unfixed, body-temperature condition image as a standard, and after extensive registration with other condition images, we ...

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    17. Quantitative optical coherence tomography tissue-type imaging for lipid-core plaque detection

      Quantitative optical coherence tomography tissue-type imaging for lipid-core plaque detection

      Comparison Between OCT Attenuation Imaging and NIRS for 3 Sites (A) NIRS/IVUS images; (B) OCT and (C) Attenuation coefficient analyzed from the OCT data (color coded 0–12 mm-1). Scale bars are 1 mm. Site 1 (refer to Fig. 1 ): a mixed lesion contains calcifications (bright echos on IVUS with dorsal shadowing; 3–5 o'clock) and lipid-rich tissue (5–10 o'clock). High attenuation (red-orange-yellow) in the plaque (white arrow) coincides with the yellow in the NIRS data. The calcification (marked by c) identified on IVUS and OCT has low attenuation (blue) . Site 2: an eccentric lipid-core plaque ...

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    18. Feature Of The Week 6/30/13: Ultrafast Intravascular Optical Coherence Tomography Imaging

      Feature Of The Week 6/30/13: Ultrafast Intravascular Optical Coherence Tomography Imaging

      The fastest commercial intravascular optical coherence tomography (OCT) systems acquire 160 frames/second with 500 lines/frame, and the pullback speed is limited to 40 mm∕s. In this situation, the images are under sampled in the pullback direction: Only 12% of the lumen is sampled because the sampling interval of 250 μm is much larger than the transverse resolution, which is approximately 30 μm. In clinical situations, the cardiac motion also affects the OCT acquisition. The pullback procedure for the whole artery takes several seconds. The cardiac motion during acquisition will cause inaccuracy in frame spacing and possibly frame ...

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    19. Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second

      Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second

      We demonstrated intravascular OCT imaging with frame rate up to 3.2 kHz (192,000 rpm scanning). This was achieved by using a custom-built catheter in which the circumferential scanning was actuated by a 1.0 mm diameter synchronous motor. The OCT system was based on a Fourier Domain Mode Locked laser operating at an A-line rate of 1.6 MHz. The diameter of the catheter was 1.1 mm at the tip. Ex vivo images of human coronary artery (~78.4 mm length) were acquired at a pullback speed of 100 mm/s. True 3D volumetric imaging of the ...

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    20. Intravascular optical coherence tomography imaging at 3200 frames per second

      Intravascular optical coherence tomography imaging at 3200 frames per second

      We demonstrate intravascular optical coherence tomography (OCT) imaging with frame rate up to 3.2 kHz (192,000 rpm scanning). This was achieved by using a custom-built catheter in which the circumferential scanning was actuated by a 1.0 mm diameter synchronous motor. The OCT system, with an imaging depth of 3.7 mm (in air), is based on a Fourier domain mode locked laser operating at an A-line rate of 1.6 MHz. The diameter of the catheter is 1.1 mm at the tip. Ex vivo images of human coronary artery (78.4 mm length) were acquired at ...

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    21. Association of neointimal morphology by optical coherence tomography with rupture of neoatherosclerotic plaque very late after coronary stent implantation.

      Association of neointimal morphology by optical coherence tomography with rupture of neoatherosclerotic plaque very late after coronary stent implantation.

      Purpose: Neoatherosclerosis within a stent has been recently described as a culprit of late stent failure. We investigated by optical coherence tomography (OCT) the association of neoatherosclerotic plaque morphology with neointimal rupture (NR) and clinical presentation in patients late after coronary stent implantation. Methods: From 1/1/2007 to 31/1/2012, 74 patients from two institutions underwent OCT assessment of a coronary stent implanted at least 18 months prior to OCT study. Native atherosclerosis criteria were used for neointimal characterization. Results: Neoatherosclerosis was observed in 59.5% of the stents (n=44). Stents with neoatherosclerosis were more often associated ...

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    22. In-stent neoatherosclerosis: are first generation drug eluting stents different than bare metal stents? an optical coherence tomography study

      In-stent neoatherosclerosis: are first generation drug eluting stents different than bare metal stents? an optical coherence tomography study

      Purpose: In-stent neoatherosclerosis has been recognised in pathologic specimens of bare metal stents (BMS), and recently in first generation drug eluting stents (1st-DES), as well. However, in vivo data are scarce. By optical coherence tomography, we investigated the incidence and morphological characteristics of neoatherosclerosis (NA) very late after BMS or 1st-DES implantation. Methods: From 1/1/2007 to 31/1/2012, 52 patients from two institutions underwent >24 months follow-up OCT assessment of a BMS or a 1st-DES (13 BMS – 39 1st-DES). NA was characterized using criteria for native atherosclerosis. Results: BMS had longer follow-up interval but no differences in ...

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    23. Optics in Cardiology Symposium 2013

      Optics in Cardiology Symposium 2013

      We are happy to announce the second edition of Optics in Cardiology, to be held on March 21/22, 2013, in Rotterdam, The Netherlands. The website for the symposium includes the list of sessions and speakers, as well as the submission form for poster abstracts, venue, and local information. Registration for the meeting is now open. The two-day symposium will provide a forum for the latest breakthroughs in applications of light in cardiovascular medicine, highlighting clinical, technological and translational advances in this fast-moving field. It aims to advance the use and development of optical techniques in cardiology, to educate clinicians ...

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    24. Numerical analysis of astigmatism correction in gradient refractive index lens based optical coherence tomography catheters

      Numerical analysis of astigmatism correction in gradient refractive index lens based optical coherence tomography catheters

      Endoscopic optical coherence tomography (OCT) catheters comprise a transparent tube to separate the imaging instrument from tissues. This tube acts as a cylindrical lens, introducing astigmatism into the beam. In this report, we quantified this negative effect using optical simulations of OCT catheter devices, and discuss possible compensation strategies. For esophageal imaging, the astigmatism is aggravated by the long working distance. For intracoronary imaging, the beam quality is degraded due to the liquid imaging environment. A nearly circular beam profile can be achieved by a curved focusing optics. We also consider the method of matching refractive indices, and it is ...

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    Quantitative Ex Vivo and In Vivo Comparison of Lumen Dimensions Measured by Optical Coherence Tomography and Intravascular Ultrasound in Human Coronary Arteries Witnessed Coronary Plaque Rupture During Cardiac Catheterization Optics In Cardiology Symposium December 1st, 2011 Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation Feature Of The Week 6/30/13: Ultrafast Intravascular Optical Coherence Tomography Imaging A Micromotor Catheter for Intravascular Optical Coherence Tomography Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography Feature Of The Week 09/10/2017: Thermo-elastic  Optical Coherence Tomography Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market Semiconductor Lasers and Diode-based Light Sources for Biophotonics (Textbook) Inside the “Razor Effect”: Lessons From Optical Coherence Tomography—What Does Angiography Hide? Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography