1. Articles from nicholas stone

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    1. Screening cervical and oesophageal tissues using optical coherence tomography

      Screening cervical and oesophageal tissues using optical coherence tomography
      Optical Coherence Tomography (OCT) is a technique that allows imaging tissue in three spatial dimensions. Such a technique makes it possible to examine the subsurface of the tissue. The depth of penetration into the tissue can be tailored by tuning the wavelength of the light source. While in some cases it is desirable to obtain deep penetration of the sample, when scanning for cancerous changes, it may only be necessary to penetrate the first few hundred micrometres. The use of a shorter wavelength, while decreasing the penetration depth, will improve the resolution of the instrument. While images from OCT systems ...
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    2. Rapid endoscopic identification and destruction of degenerating Barrett’s mucosal neoplasia

      Rapid endoscopic identification and destruction of degenerating Barrett’s mucosal neoplasia
      There are distinct challenges implicit to the development of minimally invasive endoscopic surgery for the eradication of early neoplasia in Barrett’s oesophagus. Endoscopic resection and ablation of high-grade dysplasia and mucosal cancer offer alternative therapeutic options to those unsuitable or unwilling to contemplate radical surgical excision. It may also become the treatment of choice in the future. Technological developments enable the instantaneous and non-invasive diagnosis of microscopic tissue abnormalities in vivo. This is made possible by improving the level of information that can be obtained from the tissue. As well as the two-dimensional surface morphology image, which the traditional ...
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    3. Optical and molecular techniques to identify tumor margins within the larynx

      Optical and molecular techniques to identify tumor margins within the larynx
      Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of ...
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    4. Towards automated classification of clinical optical coherence tomography data of dense tissues

      The native contrast of optical coherence tomography (OCT) data in dense tissues can pose a challenge for clinical decision making. Automated data evaluation is one way of enhancing the clinical utility of measurements. Methods for extracting information from structural OCT data are appraised here. A-scan analysis allows characterization of layer thickness and scattering parameters, whereas image analysis renders itself to segmentation, texture and speckle analysis. All fully automated approaches combine pre-processing, feature registration, data reduction, and classification. Pre-processing requires de-noising, feature recognition, normalization and refining. In the current literature, image exclusion criteria, initial parameters, or manual input are common requirements ...
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    5. Near real-time classification of optical coherence tomography data using principal components fed linear discriminant analysis

      Florian Bazant-Hegemark and Nicholas Stone An optical coherence tomography (OCT) prediction algorithm is designed and tested on a data set of sample images (taken from vegetables and porcine tissues) to demonstrate proof of concept. Preprocessing and classification of data are fully automated, at a rate of 60,000 A-scans/min on a standard c ... [J. Biomed. Opt. 13, 034002 (2008)] published Thu May 22, 2008.
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Gloucestershire Royal Hospital
    2. (4 articles) Florian Bazant-Hegemark
    3. (2 articles) Cranfield University
    4. (1 articles) UK National Physical Laboratory
    5. (1 articles) Hugh Barr
    6. (1 articles) Nick Stone
    7. (1 articles) Michelson Diagnostics
    8. (1 articles) National Taiwan University
    9. (1 articles) Medical University of Vienna
    10. (1 articles) UCSD
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    Optical and molecular techniques to identify tumor margins within the larynx Rapid endoscopic identification and destruction of degenerating Barrett’s mucosal neoplasia Screening cervical and oesophageal tissues using optical coherence tomography Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement Oral cancer detection using optical coherence tomography – A detailed review Increased crystalline lens coverage in optical coherence tomography with oblique scanning and volume stitching Imaging Hyperreflective Foci as an Inflammatory Biomarker after Anti-VEGF Treatment in Neovascular Age-Related Macular Degeneration Patients with Optical Coherence Tomography Angiography Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients With Nasopharyngeal Carcinoma Optical coherence tomography detection of vulnerable plaques at high risk of developing acute coronary syndrome Retinal microvasculature impairments in patients with coronary artery disease: An optical coherence tomography angiography study Precise higher-order reflectivity and morphology models for early diagnosis of diabetic retinopathy using OCT images