1. Articles from Kenneth Lee

    1-5 of 5
    1. Graphics processor unit acceleration enables realtime endovascular Doppler optical coherence tomography imaging

      Graphics processor unit acceleration enables realtime endovascular Doppler optical coherence tomography imaging

      Endovascular Optical Coherence Tomography (OCT) has previously been used in both bench-top and clinical environments to produce vascular images, and can be helpful in characterizing, among other pathologies, plaque build-up and impedances to normal blood ow. The raw data produced can also be processed to yield high- resolution blood velocity information, but this computation is expensive and has previously only been available a posteriori using post-processing software. Real-time Doppler OCT (DOCT) imaging has been demonstrated before in the skin and eye, but this capability has not been available to vascular surgeons. Graphics Processing Units (GPUs) can be used to dramatically ...

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    2. Ability of optical coherence tomography to detect caries beneath commonly used dental sealants

      Ability of optical coherence tomography to detect caries beneath commonly used dental sealants
      Background and Objective The onset and progression of early tooth decay is often preventable with dental sealants. However, occasionally decay progresses underneath the sealant. Current technology does not permit monitoring of potential lesion progression or arrest. Dental sealants themselves mask the visual cues that identify early tooth decay, and radiographs are not sufficiently sensitive. Therefore, clinicians can be reluctant to use dental sealant. The objective of this ex vivo study was to evaluate the ability of dentists to detect decay beneath commonly used dental sealants using optical coherence tomography (OCT) imaging. Study Designs/Materials/Methods Forty extracted teeth were divided ...
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    3. Optimized speckle variance OCT imaging of microvasculature

      Optimized speckle variance OCT imaging of microvasculature
      We optimize speckle variance optical coherence tomography (svOCT) imaging of microvasculature in high and low bulk tissue motion scenarios. To achieve a significant level of image contrast, frame rates must be optimized such that tissue displacement between frames is less than the beam radius. We demonstrate that higher accuracy estimates of speckle variance can enhance the detection of capillaries. These findings are illustrated in vivo by imaging the dorsal window chamber model (low bulk motion). We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT.
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    4. Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration

      Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
      We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is nearly antiparallel to the imaging direction. These images are acquired using a flexible 2.2-mm-diam catheter that used electrostatic actuation to scan up to 30 deg ahead of the distal ...
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    5. In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients

      In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies.To evaluate the clinical capability of non-invasive in vivo OCT for diagnosing oral dysplasia and malignancy.In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blinded, pre-standardized investigators separately diagnosed each lesion based on (1) OCT and (2) histopathology.Intra- and inter-observer agreement between diagnoses based on histopathology and imaging data was excellent, with [kappa] values between 0.844 and 0.896. Sensitivity ...
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      Mentions: UC Irvine UCLA
    1-5 of 5
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  2. Topics in the News

    1. (3 articles) University of Toronto
    2. (2 articles) UC Irvine
    3. (2 articles) Ryerson University
    4. (1 articles) UCLA
    5. (1 articles) Sunnybrook Health Sciences Centre
    6. (1 articles) Harvard University
    7. (1 articles) University of Southern California
    8. (1 articles) Ontario Cancer Institute
    9. (1 articles) Jikei University School of Medicine
    10. (1 articles) Stanford University
    11. (1 articles) University of Pittsburgh
    12. (1 articles) Case Western Reserve University
    13. (1 articles) Pusan National University
    14. (1 articles) VU University Amsterdam
    15. (1 articles) University of Toronto
    16. (1 articles) Cleveland Clinic
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    Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration Optimized speckle variance OCT imaging of microvasculature Ability of optical coherence tomography to detect caries beneath commonly used dental sealants Graphics processor unit acceleration enables realtime endovascular Doppler optical coherence tomography imaging Advances in bronchoscopic optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases Morphologic Stages of Rhegmatogenous Retinal Detachment Assessed with Swept-Source Optical Coherence Tomography En Face Images Using Ultra-Widefield Optical Coherence Tomography in 2 Cases of Traumatic Hypotony Maculopathy before and after Surgical Intervention Clinical Course of OCTA en face Imaging Findings in a Patient with HELLP Syndrome Values of optical coherence tomography angiography for diagnosing diabetic retinopathy and evaluating treatment outcomes Deep learning approaches to predict 10-2 visual field from wide-field swept-source optical coherence tomography en face images in glaucoma Quantification of Macular Perfusion Following Panretinal Photocoagulation for Diabetic Retinopathy: An Optical Coherence Tomography Angiography Study The effect of topical steroids and non-steroidal anti inflammatory drugs on epiphora of unknown cause: Optical Coherence Tomography Study