1. Articles from sven becker

    1-6 of 6
    1. Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography

      Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography

      Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway narrowing responses across a portion of the porcine bronchial tree was determined in vitro. The portion comprised contiguous airways spanning bronchial generations (#3-11), including the associated side branches. We used ...

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    2. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter with a range of imaging modalities. We describe a new optical technique, anatomical optical coherence tomography (aOCT), which allows changes at the luminal surface (airway caliber) to be temporally related ...

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    3. Respiratory gating of anatomical optical coherence tomography images of the human airway

      Respiratory gating of anatomical optical coherence tomography images of the human airway
      Anatomical optical coherence tomography (aOCT) is a longrange endoscopic imaging modality capable of quantifying size and shape of the human airway. A challenge to its in vivo application is motion artifact due to respiratory-related movement of the airway walls. This paper represents the first demonstration of respiratory gating of aOCT airway data, and introduces a novel error measure to guide appropriate parameter selection. Results indicate that at least four gates per respiratory cycle should be used, with only minor improvements as the number of gates is further increased. It is shown that respiratory gating can substantially improve the quality of ...
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    4. Using Optical Coherence Tomography To Improve Diagnostic and Therapeutic Bronchoscopy

      Background Flexible bronchoscopy is a common procedure used in both diagnostic and therapeutic settings but does not readily permit measurement of central airway dimensions. Anatomical optical coherence tomography (aOCT), a modification of conventional optical coherence tomography (OCT), is a novel, light-based imaging tool with the capacity to accurately measure diameter and lumen area of the central airways during bronchoscopy. This study describes the first clinical use of anatomical optical coherence tomography in the lower airways in three individuals with common endobronchial pathologies. Methods During bronchoscopy, a specialized fiber-optic probe was passed through the biopsy channel of a standard flexible bronchoscope ...
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    5. Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway

      Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
      Endoscopic treatment of lower airway pathologies requires accurate quantification of airway dimensions. We demonstrate the application of a real-time endoscopic optical coherence tomography system that can image lower airway anatomy and quantify airway lumen dimensions intra-operatively. Results ... [Opt. Express 16, 17521-17529 (2008)]
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    6. Respiratory gating of endoscopic OCT images of the upper airway

      Robert A. McLaughlin, Julian J. Armstrong, Sven Becker et al. Anatomical optical coherence tomography (aOCT) is an endoscopic imaging modality that can be used to quantify size and shape of the upper airway. We report the application of respiratory gating to aOCT images. Our results show that respiratory gating can reduce motion artefact in upper airway images ... [Proc. SPIE 7004, 70045V (2008)] published Fri May 16, 2008.
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    1-6 of 6
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  2. Topics in the News

    1. (6 articles) University of Western Australia
    2. (6 articles) Peter R. Eastwood
    3. (6 articles) Julian J. Armstrong
    4. (6 articles) Robert A. McLaughlin
    5. (6 articles) David D. Sampson
    6. (6 articles) David R. Hillman
    7. (4 articles) Sir Charles Gairdner Hospital
    8. (4 articles) Jonathan P. Williamson
    9. (2 articles) Peter B. Noble
    10. (2 articles) Martin J. Phillips
    11. (1 articles) University of Pennsylvania
    12. (1 articles) National Institutes of Health
    13. (1 articles) Peking University
    14. (1 articles) FDA
    15. (1 articles) Washington University in St. Louis
    16. (1 articles) Lehigh University
    17. (1 articles) Duke University
    18. (1 articles) Massachusetts Institute of Technology
    19. (1 articles) Chao Zhou
    20. (1 articles) James G. Fujimoto
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    Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway Respiratory gating of anatomical optical coherence tomography images of the human airway Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography Optical Coherence Tomography Characteristics of the Choroid Underlying Congenital Hypertrophy of the Retinal Pigment Epithelium Kylee Hall joins Cylite as VP Sales and Marketing Consolidation of Imaging Modalities Utilizing Digitally Assisted Visualization Systems: The Development of a Surgical Information Handling Cockpit Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis Identification of atherosclerotic plaques in intravascular optical coherence tomography images based on textures and artificial neural network Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography Diagnostic ability of vessel density measured by spectral-domain optical coherence tomography angiography for glaucoma in patients with high myopia