1. Articles from Jeremy D. Rogers

    1-5 of 5
    1. Noise reduction in supercontinuum sources for OCT by single-pulse spectral normalization

      Noise reduction in supercontinuum sources for OCT by single-pulse spectral normalization

      Supercontinuum (SC) sources offer high illumination power from a single-mode fiber with large spectral bandwidth including the visible spectrum, which is a growing application area for optical coherence tomography (OCT). However, SC spectra suffer from pulse-to-pulse variations, increasing noise in the resulting images. By simultaneously collecting a normalization spectrum, OCT image noise can be reduced by more than half (7 dB) for single pulses without any pulse averaging using only simple optical components.

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    2. Platform for quantitative multiscale imaging of tissue composition

      Platform for quantitative multiscale imaging of tissue composition

      Changes in the multi-level physical structure of biological features going from cellular to tissue level composition is a key factor in many major diseases. However, we are only beginning to understand the role of these structural changes because there are few dedicated multiscale imaging platforms with sensitivity at both the cellular and macrostructural spatial scale. A single platform reduces bias and complications from multiple sample preparation methods and can ease image registration. In order to address these needs, we have developed a multiscale imaging system using a range of imaging modalities sensitive to tissue composition: Ultrasound, Second Harmonic Generation Microscopy ...

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    3. Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

      Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

      Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible and near-infrared OCT image analysis demonstrated increased scattering coefficients ( μ s ) in ablated versus normal tissues (Vis: 347.8%, NIR: 415.0%) and shows the potential for both wavelength ranges to ...

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    4. Can OCT be sensitive to nanoscale structural alterations in biological tissue?

      Can OCT be sensitive to nanoscale structural alterations in biological tissue?

      Exploration of nanoscale tissue structures is crucial in understanding biological processes. Although novel optical microscopy methods have been developed to probe cellular features beyond the diffraction limit, nanometer-scale quantification remains still inaccessible for in situ tissue. Here we demonstrate that, without actually resolving specific geometrical feature, OCT can be sensitive to tissue structural properties at the nanometer length scale. The statistical mass-density distribution in tissue is quantified by its autocorrelation function modeled by the Whittle-Mateŕn functional family. By measuring the wavelength-dependent backscattering coefficient μb(λ) and the scattering coefficient μs, we introduce a technique called inverse spectroscopic OCT (ISOCT) to quantify ...

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    5. Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy

      Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy
      Low-coherence enhanced backscattering (LEBS) is a depth selective technique that allows noninvasive characterization of turbid media such as biological tissue. LEBS provides a spectral measurement of the tissue reflectance distribution as a function of distance between incident and reflected ray pairs through the use of partial spatial coherence broadband illumination. We present LEBS as a new depth-selective technique to measure optical properties of tissue in situ. Because LEBS enables measurements of reflectance due to initial scattering events, LEBS is sensitive to the shape of the phase function in addition to the reduced scattering coefficient (μs*). We introduce a simulation of ...
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    1-5 of 5
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  2. Topics in the News

    1. (3 articles) University of Wisconsin
    2. (2 articles) Northwestern University
    3. (2 articles) Vadim Backman
    4. (1 articles) Melissa C. Skala
    5. (1 articles) Ji Yi
    6. (1 articles) Jikei University School of Medicine
    7. (1 articles) Macquarie University
    8. (1 articles) Medical University of Vienna
    9. (1 articles) University of Florence
    10. (1 articles) National Institutes of Health
    11. (1 articles) Beth Israel Deaconess Medical Center
    12. (1 articles) Giacomo Savini
    13. (1 articles) Bernhard Baumann
    14. (1 articles) Antonia Lichtenegger
    15. (1 articles) Movu
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