1. Articles from owen christopher raffel

    1-7 of 7
    1. Optical coherence tomography-based patient-specific coronary artery reconstruction and fluid–structure interaction simulation

      Optical coherence tomography-based patient-specific coronary artery reconstruction and fluid–structure interaction simulation

      Plaque rupture is related to the mechanical stress it suffered. The value and distribution of the mechanical stress in plaque could help on assessing plaque vulnerability. To look into the stress conditions in the coronary artery, a patient-specific coronary model was created by using optical coherence tomography (OCT) and angiography imaging data. The reconstructed coronary model consisted of the structure of the lumen, the arterial wall and plaque components. Benefited by the high resolution of OCT, detailed structures such as the thin fibrous cap could be observed and built into the geometry. On this reconstructed coronary model, a fully coupled ...

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    2. Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity

      Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity

      ims: A novel method for computation of fractional flow reserve (FFR) from optical coherence tomography (OCT) was developed recently. This study aimed to evaluate the diagnostic accuracy of a new OCT-based FFR (OFR) computational approach, using wire-based FFR as the reference standard. Methods and results: Patients who underwent both OCT and FFR prior to intervention were analysed. The lumen of the interrogated vessel and the ostia of the side branches were automatically delineated and used to compute OFR. Bifurcation fractal laws were applied to correct the change in reference lumen size due to the step-down phenomenon. OFR was compared with ...

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    3. A Rare Mechanism of Very Late Bare Metal Stent Thrombosis—Role of Optical Coherence Imaging in Its Evaluation and Management

      A Rare Mechanism of Very Late Bare Metal Stent Thrombosis—Role of Optical Coherence Imaging in Its Evaluation and Management

      Very late stent thrombosis is an uncommon event following implantation with bare metal stents (BMS) in coronary arteries. Long term follow up studies have shown that a small number of BMS develop very late thrombosis following years of stability. Atherosclerotic transformation of neointimal tissue is increasingly being recognised as the cause of these adverse events. A 49 year-old male presented with acute inferior wall myocardial infarction resulting from thrombosis of the BMS implanted in his right coronary artery five years earlier. He was successfully thrombolysed and his coronary angiogram showed mild diffuse instent restenosis. The intravascular optical coherence tomography revealed ...

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    4. Optical coherence tomography of late acquired bare metal stent malapposition: Bare metal stent “diverticulosis”

      Optical coherence tomography of late acquired bare metal stent malapposition: Bare metal stent “diverticulosis”

      Figure 1. Coronary angiogram and optical coherence tomographic (OCT) images of the right coronary artery. (A) Initial lesion prior to stent placement. (B) Immediately post stent insertion. (C) At repeat angiography for NSTEMI demonstrating presence of multiple prominent “diverticuli” in the mid-segment of the stent (arrow). (D and E) OCT images demonstrating LASMA with poor neointimal coverage of affected struts and microthrombi formation within the outpouchings (arrows). (F) OCT image demonstrating good neointimal coverage of other segments of the stent. The lower OCT panel shows a longitudinal view of the pullback (proximal segments on right) with representative cross-sectional frames at ...

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    5. Spontaneous Coronary Artery Dissection: Utility of Intravascular Ultrasound and Optical Coherence Tomography During Percutaneous Coronary Intervention [Images and Case Reports in Interventional Cardiology]

      Spontaneous Coronary Artery Dissection: Utility of Intravascular Ultrasound and Optical Coherence Tomography During Percutaneous Coronary Intervention [Images and Case Reports in Interventional Cardiology]

      Spontaneous coronary artery dissection (SCAD) is an infrequent cause of acute coronary syndromes but is represented disproportionately in young female patients. No specific guidelines exist concerning the appropriate treatment (medical therapy, intracoronary stents, coronary bypass surgery) or the optimal type of stents in otherwise atheroma-free vessels. The role of intracoronary imaging with intravascular ultrasound (IVUS) and optical coherence tomography (OCT) has yet to be fully established. A 39-year-old woman with no traditional risk factors for coronary artery disease presented with an anterior ST-segment elevation myocardial infarct after undergoing rigorous aerobic exercises. The patient was gravida 3 para 3, not known ...

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    6. In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography

      Aims: Positive coronary arterial remodelling has been shown to be associated with unstable coronary syndromes and ex vivo histological characteristics of plaque vulnerability such as a large lipid core and high macrophage content. The aim of this study is to evaluate the in vivo association between coronary artery remodelling and underlying plaque characteristics identified by optical coherence tomography (OCT). OCT is a unique imaging modality capable of characterizing these important morphological features of vulnerable plaque. Methods and results: OCT and intravascular ultrasound imaging was performed at corresponding sites in patients undergoing catheterization. OCT plaque characteristics for lipid content, fibrous cap ...
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    7. Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study.

      Coronary Artery Disease. 19(4):237-242, June 2008. Chia, Stanley a; Raffel, Owen Christopher a; Takano, Masamichi c; Tearney, Guillermo J. b; Bouma, Brett E. b; Jang, Ik-Kyung a Abstract: Objective: Statin therapy induces plaque regression and may stabilize atheromatous plaques. Optical coherence tomography (OCT) is a high-resolution in-vivo imaging modality that allows characterization of atherosclerotic plaques. We aimed to demonstrate the potential utility of OCT in evaluating coronary plaque
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    1-7 of 7
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    Spontaneous Coronary Artery Dissection: Utility of Intravascular Ultrasound and Optical Coherence Tomography During Percutaneous Coronary Intervention [Images and Case Reports in Interventional Cardiology] Optical coherence tomography of late acquired bare metal stent malapposition: Bare metal stent “diverticulosis” A Rare Mechanism of Very Late Bare Metal Stent Thrombosis—Role of Optical Coherence Imaging in Its Evaluation and Management Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity Optical coherence tomography-based patient-specific coronary artery reconstruction and fluid–structure interaction simulation Line-field confocal optical coherence tomography-Practical applications in dermatology and comparison with established imaging methods Optical coherence tomography detection of changes in inner retinal and choroidal thicknesses in patients with early retinitis pigmentosa Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement Characterization of microvascular tortuosity in retinal vein occlusion utilizing optical coherence tomography angiography Evaluation of retinochoroidal tissues in third trimester pregnants: An optical coherence tomography angiography study Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography OCTA Study: Retinal Vascular Changes in COVID19 Patients