1. Articles from Jing Wang

    1-12 of 12
    1. Unsupervised domain adaptation model for lesion detection in retinal OCT images

      Unsupervised domain adaptation model for lesion detection in retinal OCT images

      Background and objective Optical Coherence Tomography (OCT) is one of the most used retinal imaging modalities in the clinic as it can provide high-resolution anatomical images. The huge number of OCT images has significantly advanced the development of deep learning methods for automatic lesion detection to ease the doctor's workload. However, it has been frequently revealed that the deep neural network (DNN) model has difficulty handling the domain discrepancies, which widely exist in medical images captured from different devices. Many works have been proposed to solve the domain shift issue in deep learning tasks such as disease classification and ...

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    2. Weakly supervised anomaly segmentation in retinal OCT images using an adversarial learning approach

      Weakly supervised anomaly segmentation in retinal OCT images using an adversarial learning approach

      Lesion detection is a critical component of disease diagnosis, but the manual segmentation of lesions in medical images is time-consuming and experience-demanding. These issues have recently been addressed through deep learning models. However, most of the existing algorithms were developed using supervised training, which requires time-intensive manual labeling and prevents the model from detecting unaware lesions. As such, this study proposes a weakly supervised learning network based on CycleGAN for lesions segmentation in full-width optical coherence tomography (OCT) images. The model was trained to reconstruct underlying normal anatomic structures from abnormal input images, then the lesions can be detected by ...

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    3. Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

      Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

      Purpose To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy. Materials and methods A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. SS-OCTA feature was vascularized PEDs on cross-sectional images corresponding to cluster-like structures ...

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    4. AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      Angle closure glaucoma (ACG) is a more aggressive disease than open-angle glaucoma, where the abnormal anatomical structures of the anterior chamber angle (ACA) may cause an elevated intraocular pressure and gradually lead to glaucomatous optic neuropathy and eventually to visual impairment and blindness. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging provides a fast and contactless way to discriminate angle closure from open angle. Although many medical image analysis algorithms have been developed for glaucoma diagnosis, only a few studies have focused on AS-OCT imaging. In particular, there is no public AS-OCT dataset available for evaluating the existing methods in a ...

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    5. The Application of Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography in Macular Diseases

      The Application of Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography in Macular Diseases

      The choroid plays an essential role in the pathogenesis of various posterior segment diseases. However, traditional imaging methods still have limited cross-sectional observation of choroid. Enhanced depth imaging in spectral-domain optical coherence tomography (EDI SD-OCT) uses a closer scanning position to the eye to create an inverted SD-OCT image with the advantage of better depth sensitivity, which can observe choroidal structure and measure choroidal thickness (CT) accurately. At present, more and more choroidal thickness measurements have been made in normal and pathologic states, in order to understand the pathogenesis and differential diagnosis and prognosis of various diseases, especially for macular ...

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    6. AGE Challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      AGE Challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      Angle closure glaucoma (ACG) is a more aggressive disease than open-angle glaucoma, where the abnormal anatomical structures of the anterior chamber angle (ACA) may cause an elevated intraocular pressure and gradually leads to glaucomatous optic neuropathy and eventually to visual impairment and blindness. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging provides a fast and contactless way to discriminate angle closure from open angle. Although many medical image analysis algorithms have been developed for glaucoma diagnosis, only a few studies have focused on AS-OCT imaging. In particular, there is no public AS-OCT dataset available for evaluating the existing methods in a ...

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    7. Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

      Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

      Purpose : We evaluate the effect of choroidal vessel density on the residual length of the ellipsoid zone (EZ) and visual function in patients with retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). Methods : Fifty-three patients with RP ( n = 101 eyes) and 53 normal participants ( n = 76 eyes) were enrolled in this study. Patients with RP were assigned to three groups according to their best-corrected visual acuity (BCVA). All patients underwent ophthalmologic examinations, including BCVA, fundus examination performed with a slit-lamp using an indirect 90 diopter (D) lens, OCTA, full-field electroretinogram (ERG), and visual field. The choroidal vessel density in ...

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    8. Efficient supercontinuum generation enabled by dispersion engineering in a dual-core waveguide

      Efficient supercontinuum generation enabled by dispersion engineering in a dual-core waveguide

      A compact dual-core waveguide is proposed for efficient supercontinuum generation, in which the use of Si-rich nitride and titanium dioxide provides a large enough index contrast for dispersion engineering. Strong anomalous group velocity dispersion is obtained over a wide bandwidth of 1860 nm which greatly reduces the dispersion length. The nonlinear length can also be significantly decreased due to high nonlinear Kerr index of Si-rich nitride. As a consequence, it could facilitate octave-spanning supercontinuum generation from 1160 to 2385 nm in a greatly reduced propagation distance, as short as 165μm . It is more than one order of magnitude shorter ...

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    9. A modified frequency domain optical coherence tomography procedure for imaging severely stenotic coronary artery lesions

      A modified frequency domain optical coherence tomography procedure for imaging severely stenotic coronary artery lesions

      Aims: This proof-of-concept study aimed to investigate the clinical feasibility of a modified frequency domain optical coherence tomography (FD-OCT) procedure for imaging severely stenotic coronary artery lesions. Methods and results: In total, 46 patients in whom clear images were unobtainable using conventional FD-OCT examination were consecutively enrolled in this study. Then, they were randomly divided into two groups: group A (FD-OCT examination using the new modified procedure, n=23), and group B (FD-OCT examination using a previously described procedure, the Yamaguchi method, n=23). The procedure success was 100% in group A and 86.96% in group B. Clear images ...

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    10. Macular changes of neuromyelitis optica through spectral-domain optical coherence tomography

      Macular changes of neuromyelitis optica through spectral-domain optical coherence tomography

      AIM : To evaluate the thickness of the retinal layers in the macula using spectral-domain optical coherence tomography (SD-OCT) in patients with neuromyelitis optica (NMO). METHODS : Spectralis SD-OCT, utilizing automated macular layer segmentation, was performed in 26 NMO patients and 26 healthy controls. Visual function including visual field tests and pattern visual evoked potential were recorded in study subjects. RESULTS : Forty-one eyes from 26 NMO patients and 52 eyes from 26 age- and sex-matched healthy controls were included. Besides total macular volume, peri-paipillary retinal nerve fiber layer (RNFL) thickness, the thickness of macular RNFL, ganglion cell layer (GCL) and inner plexiform ...

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    11. Switchable skin window induced by optical clearing method for dermal blood flow imaging

      Switchable skin window induced by optical clearing method for dermal blood flow imaging

       Optical imaging techniques have shown tremendous potential for assessing cutaneous microcirculation, but the imaging depth and contrast is limited by the strong scattering of skin. Current skin windows have to be fulfilled by surgical operation and suffer from some side effects. In this study, a switchable skin window was developed by topical application of an optical clearing agent (OCA) and saline on rat skin in vivo. The validity of the skin window was evaluated by the laser speckle contrast imaging technique, and the safety of OCA to the body was tested through histologic examinations. The results indicated that administration of ...

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    12. Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen

      Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen
      We proposed to measure the metabolic rate of oxygen (MRO2) in small animals in vivo using a multimodal imaging system that combines laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) and spectral-domain optical coherence tomography (SD-OCT). We first tested the capability of the multimodal system to measure flow rate in a phantom made of two capillary tubes of different diameters. We then demonstrated the capability of measuring MRO2 by imaging two parallel vessels selected from the ear of a Swiss Webster mouse. The hemoglobin oxygen saturation (sO2) and the vessel diameter were measured by the LSOR-PAM and the blood flow velocity was measured ...
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    1-12 of 12
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    1. (3 articles) Sun Yat-Sen University
    2. (3 articles) Shanghai Jiao Tong University
    3. (2 articles) Medical University of Vienna
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    Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen Switchable skin window induced by optical clearing method for dermal blood flow imaging Macular changes of neuromyelitis optica through spectral-domain optical coherence tomography A modified frequency domain optical coherence tomography procedure for imaging severely stenotic coronary artery lesions Efficient supercontinuum generation enabled by dispersion engineering in a dual-core waveguide Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography AGE Challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography The Application of Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography in Macular Diseases AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography? Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis Clinical presentation does not affect acute mechanical performance of the Novolimus-eluting bioresorbable vascular scaffold as assessed by optical coherence tomography