1. Articles from Mays El-Dairi

    1-12 of 12
    1. Quantitative topographic curvature maps of the posterior eye utilizing optical coherence tomography

      Quantitative topographic curvature maps of the posterior eye utilizing optical coherence tomography

      Purpose: Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an OCT based method for the generation of quantitative posterior eye topography maps in normal and pathologic eyes. Methods: Utilizing “ whole eye ” OCT we corrected for subjects’ optical distortions to generate spatially accurate posterior eye OCT volumes and created local curvature ( K M , mm -1 ) topography maps for each consented subject. We imaged nine subjects, three normal, two with myopic degeneration (MD), and four with papilledema including one that was imaged longitudinally ...

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    2. Longitudinal reproducibility of spectral domain optical coherence tomography in children with physiologic cupping and stable glaucoma

      Longitudinal reproducibility of spectral domain optical coherence tomography in children with physiologic cupping and stable glaucoma

      Purpose To determine whether Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography (SD-OCT) measurements are reproducible over time in children with physiologic cupping and stable glaucoma. Methods Subjects were identified from a subset of participants in an earlier retrospective study conducted by our group and included children (<18 years of age) with physiologic cupping and stable primary congenital glaucoma (PCG) having had at least 2 SD-OCTs over a period of more than 1 between April 2010 and September 2015. Thicknesses of average peripapillary retinal nerve fiber layer (pRNFL) and six individual sectors and volumes of three segmented retinal layers and ...

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    3. The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

      The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

      Background Recent Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography (SD-OCT) research software can automatically quantify the thickness of each individual retinal layer. The macular ganglion cell layer (GCL) and ganglion cell complex may be more sensitive for detecting glaucoma than the peripapillary retinal nerve fiber layer (pRNFL). The aim of this study was to characterize and compare the volume of each macular layer in the eyes of children with glaucoma versus those of normal controls. Methods The medical records of children with primary glaucoma and physiologic cupping who had undergone Spectralis SD-OCT imaging of the macula and pRNFL were ...

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    4. The application of optical coherence tomography in neurologic diseases

      The application of optical coherence tomography in neurologic diseases

      Optical coherence tomography (OCT) has become an increasingly popular tool in various disciplines of medicine, particularly ophthalmology and neurology. It is an imaging technology that has revolutionized the practice of ophthalmology by providing anatomic detail of pathologic changes in the retina and optic nerve. OCT is routinely used as an ancillary test that can aid in the diagnosis and monitoring of neuro-ophthalmic diseases such as papilledema, optic neuritis, and neuroretinitis. OCT measurements have also been shown to predict visual prognosis in compressive optic neuropathies. Changes in OCT measurements have been used to study the course of particular neurologic diseases such ...

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    5. The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation

      The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation

      Recent Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography research software can quantify the thickness of each individual retinal layer. There is a suggestion that the macular ganglion cell layer (GCL) and ganglion cell complex may be more sensitive for detecting glaucoma than the peripapillary retinal nerve fiber layer (pRNFL). The purpose of this study was to characterize/compare the thickness of each macular layer among children with glaucoma versus normals.

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    6. Evaluation of Optic Nerve Development in Preterm and Term Infants Using Handheld Spectral-Domain Optical Coherence Tomography

      Evaluation of Optic Nerve Development in Preterm and Term Infants Using Handheld Spectral-Domain Optical Coherence Tomography

      Purpose To evaluate effects of prematurity on early optic nerve (ON) development and the usefulness of ON parameters as indicators of central nervous system (CNS) development and pathology. Design Prospective, cross-sectional, longitudinal study. Participants Forty-four preterm infants undergoing retinopathy of prematurity (ROP) screening and 52 term infants. Methods We analyzed ON from portable handheld spectral-domain optical coherence tomography (SD-OCT) images (Bioptigen, Inc, Research Triangle Park, NC) of 44 preterm and 52 term infants. The highest-quality ON scan from either eye was selected for quantitative analysis. Longitudinal analysis was performed at 31–36 weeks and 37–42 weeks postmenstrual age (PMA ...

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    7. Optical coherence tomography in the management of congenital glaucoma

      Optical coherence tomography in the management of congenital glaucoma

      Primary congenital glaucoma (PCG) is a rare disorder with an incidence of about 0.38–5.4 in 100 000 1 , 2 but it can result in significant visual morbidity. 3 PCG is usually diagnosed during infancy and treated with angle surgery; however, patients usually need monitoring for life as up to 57% 1 may still need chronic treatment with drops or secondary procedures. The gold standard for monitoring glaucoma in adults and children includes intraocular pressure measurements, monitoring of the optic nerve cup-to-disc ratio and visual fields. Although children have been reported to be able to perform visual fields ...

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      Mentions: Duke University
    8. Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements in Adult and Pediatric Glaucoma

      Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements in Adult and Pediatric Glaucoma

      Purpose: To determine the reproducibility of spectral-domain optical coherence tomography (OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) and macular retinal thickness of the central 20-degree area of the posterior pole in adult and pediatric glaucoma and normal subjects. Methods: Normal, glaucoma suspect and glaucoma eyes of adult and pediatric subjects were recruited. Spectralis OCT scans were obtained 3 times on the same day (intravisit) and 4 weeks later (intervisit). Six individual sectors, average RNFL, and macular retinal thickness using an 8x8 mm grid centered on the foveal pit were measured for all the eyes. The central 16 square ...

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    9. Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain

      Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain

      Background/aims Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma and determine its agreement with TD-OCT. Methods Children who had SD-OCT(Spectralis, Heidelberg-Engineering,Germany) were retrospectively and prospectively identified from Duke paediatric glaucoma clinic. The peripapillary retinal nerve fibre layer (RNFL) and macular thickness and volume (MV) were compared amongst four groups: normal eyes, eyes with physiologic cupping (C:D >0.5 and <0.8, IOP <21), mild glaucomatous eyes (C:D ...

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    10. Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios

      Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios
      Children with large optic nerve head cups often pose diagnostic difficulty due to concern over possible glaucoma. This study's purpose was to evaluate optical coherence tomography (OCT) measurement of the peripapillary retinal nerve fiber layer (RNFL) and macular thickness in healthy eyes of black and white children, comparing values for eyes with large cup-to-disc ratios against those with small cup-to-disc ratios (normal controls). Using Stratus OCT (OCT 3) (Carl Zeiss Meditec, Dublin, CA) a fast macular thickness and fast RNFL 3.4 protocol were performed on normal eyes of normal children. Included were children (aged 5-17 years) with normal ...
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    11. Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography

      Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography
      Abstract: Background: In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiating glaucomatous from non-glaucomatous optic nerve cupping in a cross-sectional pilot study. Methods: Eleven consecutive patients presenting to the Duke Eye Center from September 2007 to July 2008 with nonglaucomatous optic nerve cupping and 12 patients with glaucomatous optic nerve cupping were identified. All patients underwent StratusĀ® OCT imaging: fast macular map, fast retinal nerve fiber layer (RNFL) 3.4 thickness, and fast optic disc ...
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    12. Technological Advances in Pediatric Eye Care

      The application of new technology is changing the practice of ophthalmology. New imaging devices, surgical procedures, and use of the Internet and powerful computers are examples of advances that have made a major impact on ophthalmology. Although pediatric ophthalmologists may not have as many new tools or treatments as our colleagues in cornea, glaucoma, or retina, our practices have nonetheless been enhanced significantly in recent years by technological advancements. New imaging devices, such as optical coherence tomography (OCT), have allowed us to view details of ocular anatomy that heretofore were not visible. Optical coherence tomography has become widely used in ...
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    1-12 of 12
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    Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements in Adult and Pediatric Glaucoma Optical coherence tomography in the management of congenital glaucoma Evaluation of Optic Nerve Development in Preterm and Term Infants Using Handheld Spectral-Domain Optical Coherence Tomography The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation The application of optical coherence tomography in neurologic diseases The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma Normal Reference Ranges of Optical Coherence Tomography Parameters in Children Optical coherence tomography angiography using the black-and-white pixel binarization histogram software: a new technique for evaluating healing of macular holes in two surgical techniques