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  1. Development of a high speed spectral domain optical coherence tomography system at 835 nm

    Explore Article SPIE Digital Library (Dec 1 2009) Developmental Biology , Doppler

    We develop a high speed multi-functional spectral domain (SD-OCT) system, using a broadband light source centered at 835nm and a custom-built spectrometer with a spectral resolution of 0.0674nm. After precise spectral calibration of the spectrometer, non-uniform discrete Fourier transform (NDFT) of the acquired spectral data is adopted for image reconstruction. In vivo imaging of human finger from volunteer at A-scan rate of 29 kHz with different reconstruction methods reveal that with the NDFT method, improved sensitivity fall-off especially at large depth is achieved in contrast to the conventional discrete Fourier transform (DFT) with interpolation method. And the phase information of ... (Read Full Article)

    Comment on Article Mentions:   Zhejiang University

  2. Time-frequency distributions in spectroscopic Fourier-domain optical coherence tomography

    Explore Article SPIE Digital Library (Nov 25 2009)

    Current analysis for spectroscopic optical coherence tomography (SOCT) signals is limited by an uncertainty relationship between time (depth) and frequency (wavelength). Various joint time-frequency distributions (TFDs) can meliorate the limits to obtain the best information. Synthesized signals which correspond to three typical SOCT signals in the Fourier-domain under different SOCT imaging schemes, were generated and validate several different TFDs, including short time Fourier transform (STFT), continuous wavelet transform (CWT), Wigner-Villy distribution (WVD), and smoothed pseudo WVD (SPWVD). We found that different SOCT imaging scheme requires different optimal TFDs. STFT offers the most reliable and fast time-frequency (TF) analysis, which is ... (Read Full Article)

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  3. Sinusoidal B-M method based spectral domain optical coherence tomography for the elimination of complex-conjugate artifact

    Explore Article opticsinfobase.org (Sep 4 2009)

    Sinusoidal B-M method based spectral domain optical coherence tomography for the elimination of complex-conjugate artifact A high speed spectral domain optical coherence tomography based on the spatial sinusoidal phase modulation for the elimination of complex-conjugate artifact is presented, where sinusoidal phase modulation of reference arm (M scan) and transverse scanning of sample arm (B scan) are performed simultaneously (sinusoidal B-M method). Herein, the linear phase modulation of the reference arm in conventional linear B-M method is modified to sinusoidal phase modulation. The proposed sinusoidal B-M method relaxes the requirements on the phase-shifting mechanical system and avoids sensitivity fall-off along the transverse direction in contrast to the linear B-M method. A criterion for the relation between ... (Read Full Article)

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  4. Two-dimensional scanning realized by an asymmetry fiber cantilever driven by single piezo bender actuator for optical coherence tomography

    Explore Article opticsinfobase.org (Jul 24 2009) Probes

    Two-dimensional scanning realized by an asymmetry fiber cantilever driven by single piezo bender actuator for optical coherence tomography We develop a fiber based probe that is capable of two-dimensional scanning applicable in optical coherence tomography (OCT). Based on the resonance of the fiber cantilever with asymmetry structure which has two distinguished resonant frequencies in orthogonal directions, Lissajous pattern is produced suitable for two-dimensional scanning upon a sample. Orthogonal resonances of the fiber cantilever are simultaneously excited by single piezo bender actuator with one driving signal consisting of two components corresponding to above-mentioned two resonant frequencies. By integrating a backward-placed two-dimensional position sensitive detector (PSD) into the probe, real-time lateral position of the scanning pattern is registered simultaneously for ... (Read Full Article)

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  5. Development of a non-uniform discrete Fourier transform based high speed spectral domain optical coherence tomography system

    Explore Article opticsinfobase.org (Jul 2 2009)

    Development of a non-uniform discrete Fourier transform based high speed spectral domain optical coherence tomography system We develop a high speed spectral domain optical coherence tomography (SD-OCT) system based on a custom-built spectrometer and non-uniform discrete Fourier transform (NDFT) to realize minimized depth dependent sensitivity fall-off. After precise spectral calibration of the spectrometer, NDFT of the acquired spectral data is adopted for image reconstruction. The spectrometer is able to measure a wavelength range of about 138nm with a spectral resolution of 0.0674nm at central wavelength of 835nm, corresponding to an axial imaging range of 2.56mm in air. Zemax simulations and sensitivity fall-off measurements under two alignment states of the spectrometer are given. Both theoretical simulations and ... (Read Full Article)

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  6. Common path endoscopic optical coherence tomography with outside path length compensation

    Explore Article SPIE Digital Library (Jan 8 2008) Endoscopy

    Yaliang Yang, Zhihua Ding, Jie Meng et al. Endoscopic optical coherence tomography (OCT) allowing high-resolution imaging of internal tissue is attractive for medical imaging. Fibre, fibre bundle or GRIN lens rod acting as endoscopic probe is placed in the sample arm of a Michelson interferometer in current endoscopic OCT systems, this arran ... [Proc. SPIE Int. Soc. Opt. Eng. 6826, 68261S (2008)] published Tue Jan 8, 2008. (Read Full Article)

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