1. Articles from U. Schmidt-Erfurth

    1-17 of 17
    1. Correlation of retinal thickness and swept-source optical coherence tomography angiography derived vascular changes in patients with neovascular age-related macular degeneration

      Correlation of retinal thickness and swept-source optical coherence tomography angiography derived vascular changes in patients with neovascular age-related macular degeneration

      Purpose: The aim of this study was to investigate whether structural OCT changes, in specific retinal thickness, is associated with the vascular response within the nAMD CNV lesion. In other words, whether SSOCTA derived parameters may prove suitable to assess CNV activity in future. Methods: During the first 3 months patients were prospectively followed with visits at days 7, and 14 after each anti-VEGF treatment up to day 90. At baseline, day 30 and 60 Aflibercept was administered. OCT-derrived retinal thickness (RT) and OCTA-derived CNV lesion parameters (vessel area [VA]), total vessel length [TVL], total number of junctions [TNJ], junction ...

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    2. Supervised learning and dimension reduction techniques for quantification of retinal fluid in optical coherence tomography images

      Supervised learning and dimension reduction techniques for quantification of retinal fluid in optical coherence tomography images

      Purpose The purpose of the present study is to develop fast automated quantification of retinal fluid in optical coherence tomography (OCT) image sets. Methods We developed an image analysis pipeline tailored towards OCT images that consists of five steps for binary retinal fluid segmentation. The method is based on feature extraction, pre-segmention, dimension reduction procedures, and supervised learning tools. Results Fluid identification using our pipeline was tested on two separate patient groups: one associated to neovascular age-related macular degeneration, the other showing diabetic macular edema. For training and evaluation purposes, retinal fluid was annotated manually in each cross-section by human ...

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    3. Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD

      Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD

      This comparative study between a SD- and SS-OCTA system for visualizing neovascular patterns in AMD, also assessed the influence of cataract on OCTA imaging. 25 eyes with active CNV (AMD) were documented by FA, ICGA and SD-OCT. Two OCTA devices were used: A custom built SS-OCTA (1050 nm, 400,000 A-scans/s, 5 × 5 mm, no image segmentation); AngioVue (OptoVue, CA, USA) SD-OCTA (840 nm, 70.000 A-scans/s, 3 × 3 mm, SSADA technology). Two retina experts graded CNV types and vascular patterns. Cataract influence on OCTA image quality was reported for the superficial retinal plexus (6 eyes). The SS-OCTA ...

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    4. A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration

      A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration

      Optical coherence tomography (OCT) has become an established diagnostic technology in the clinical management of age-related macular degeneration (AMD). OCT is being used for primary diagnosis, evaluation of therapeutic efficacy, and long-term monitoring. Computer-based advances in image analysis provide complementary imaging tools such as OCT angiography, further novel automated analysis methods as well as feature detection and prediction of prognosis in disease and therapy by machine learning. In early AMD, pathognomonic features such as drusen, pseudodrusen, and abnormalities of the retinal pigment epithelium (RPE) can be imaged in a qualitative and quantitative way to identify early signs of disease activity ...

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    5. Comparison of penetration depth in choroidal imaging using swept source vs spectral domain optical coherence tomography

      Comparison of penetration depth in choroidal imaging using swept source vs spectral domain optical coherence tomography

      Purpose To compare signal penetration depth and deep structure-visualization of swept source (SS) and spectral domain (SD)-optical coherence tomography (OCT) with and without enhanced depth imaging (EDI) and B-scan averaging modes. Methods Volume scans were obtained from 20 eyes of healthy volunteers by DRI OCT-1, Spectralis using EDI and B-scan averaging, and Cirrus HD-OCT. The signal penetration depth was measured as the distance between the retinal pigment epithelium and the deepest visible anatomical structure at the foveal center. Visibility and contrast of the choroidoscleral junction and of vascular details within the choroid were assessed across the entire volume using ...

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    6. Reproducibility of High Resolution Optical Coherence Tomography Measurements of the Nerve Fiber Layer with the new Heidelberg Spectralis OCT

      Reproducibility of High Resolution Optical Coherence Tomography Measurements of the Nerve Fiber Layer with the new Heidelberg Spectralis OCT
      Abstract Purpose Conventional time-domain OCT technology for detection of retinal nerve fiber layer (RNFL) neurodegeneration suffers from technical inaccuracy due to a lack of exact scan centering around the optic disc as well as a true follow-up possibility. In this study, we evaluated a novel high-resolution Spectral-domain OCT device (SD-OCT) with an incorporated eye-tracking feature in its ability to objectively measure the RNFL thickness (RNFLT) by testing intra-observer reproducibility in a series of healthy volunteers. Methods Triplicate circumferential RNFL scans of six peripapillary sectors were obtained from both eyes of all 31 participants. We compared the measurements of RNFLT during ...
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    7. Performance of Automated Drusen Detection by Polarization-sensitive Optical Coherence Tomography

      Performance of Automated Drusen Detection by Polarization-sensitive Optical Coherence Tomography
      Purpose: To estimate the potential of polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of drusen in patients with early age-related macular degeneration (AMD). Methods: Fifteen eyes of thirteen patients presenting drusen consistent with AREDS 2 and 3 classification were examined ophthalmoscopically, followed by fundus photography, autofluorescence imaging and three-dimensional scanning using a PS-OCT. For the automated evaluation of drusen location, area and volume, a novel segmentation algorithm was developed based on the polarization scrambling characteristics of the retinal pigment epithelium (RPE) and applied to each complete dataset. Subsequently, the drusen in each individual B-scan were identified by two independent ...
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    8. Comparison of retinal thickness values and segmentation performance of different OCT devices in acute branch retinal vein occlusion

      Comparison of retinal thickness values and segmentation performance of different OCT devices in acute branch retinal vein occlusion
      Purpose To compare retinal thickness (RT) measurement and segmentation performance of time domain (TD, Stratus) and spectral domain (SD) optical coherence tomography (OCT) devices (Cirrus, Spectralis) for imaging macular oedema (ME) secondary to branch retinal vein occlusion (BRVO). Methods In this study, 20 eyes of 20 consecutive patients with acute BRVO were included. A total of 18 unaffected fellow eyes served as control group. RT measurement was analysed in the five inner fields of the early-treatment diabetic retinopathy grid, and proportional segmentation errors were evaluated. Results Central millimetre thickness (CMT) showed a mean difference of −64, −74, and −18 μm ...
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    9. Reproducibility of high-resolution optical coherence tomography measurements of the nerve fibre layer with the new Heidelberg Spectralis optical coherence tomography

      Reproducibility of high-resolution optical coherence tomography measurements of the nerve fibre layer with the new Heidelberg Spectralis optical coherence tomography
      Aim Conventional time-domain OCT technology for detection of retinal nerve fibre layer (RNFL) neurodegeneration suffers from technical inaccuracy owing to a lack of exact scan centring around the optic disc as well as a true follow-up possibility. In this study, the authors evaluated a novel high-resolution spectral-domain OCT device (SD-OCT) with an incorporated eye-tracking feature in its ability to objectively measure the RNFL thickness (RNFLT) by testing intraobserver reproducibility in a series of healthy volunteers. Methods Triplicate circumferential RNFL scans of six peripapillary sectors were obtained from both eyes of all 31 participants. The authors compared the measurements of RNFLT ...
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    10. Comparison of retinal thickness measurements and segmentation performance of four different spectral and time domain OCT devices in neovascular age-related macular degeneration

      Aims: To evaluate the reliability of different optical coherence tomography (OCT) devices and scanning patterns in the assessment of retinal thickness and segmentation performance in neovascular age-related macular degeneration (nAMD). Methods: 28 eyes with nAMD and 10 healthy eyes were imaged using conventional time domain (TD) OCT as well as three spectral-domain (SD) OCT systems. Radial scans of 6 mm in size were compared between Stratus and Topcon OCT, in addition to raster scans of all three SD-OCT devices. Retinal thickness values were analysed. Results: Spectralis SD-OCT demonstrated the highest values of all OCT devices in central millimetre thickness (CMMT ...
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    11. Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration.

      Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration. Ophthalmology. 2008 Aug;115(8):e39-46 Authors: Ahlers C, Golbaz I, Stock G, Fous A, Kolar S, Pruente C, Schmidt-Erfurth U PURPOSE: To analyze the effect of ranibizumab therapy on retinal and subretinal compartments in age-related macular degeneration and to compare the time course of compartment specific effects to visual function. DESIGN: Prospective noncomparative case series. PARTICIPANTS: Fourteen patients with changes in 3 major compartments owing to neovascular age-related macular degeneration. METHODS: Standard treatment with 3 monthly doses of intravitreal ranibizumab was performed. Eyes ...
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    12. Three-dimensional imaging in central serous chorioretinopathy.

      Ophthalmologe. 2008 Apr 27; Authors: Stock G, Ahlers C, Sayegh R, Ritter M, Kolar S, Golbaz I, Schmidt-Erfurth U BACKGROUND: Conventional optical coherence tomography (OCT) has brought new insights to retinal diagnostics, but it is restricted due to its low scanning speed and limited resolution. In this study, high-resolution raster scanning OCT (HR-OCT) was used to identify typical changes in central serous chorioretinopathy (CSC). METHODS: Fifteen consecutive patients with acute CSC were imaged using HR-OCT with an axial image resolution of 6 mum. The scanned area measured 6x6 mm(2). Three-dimensional (3D) evaluation was performed using various analysing programmes. RESULTS ...
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    13. High-resolution optical coherence tomography to evaluate vitreomacular traction before and after membrane peeling.

      Related Articles [High-resolution optical coherence tomography to evaluate vitreomacular traction before and after membrane peeling.] Ophthalmologe. 2008 Mar 29; Authors: Georgopoulos M, Geitzenauer W, Ahlers C, Simader C, Scholda C, Schmidt-Erfurth U AIM: Morphological assessment of the vitreomacular interface and intraretinal architecture using three-dimensional high-resolution optical coherence tomography (HROCT) before and after surgical delamination of epiretinal membranes and the internal limiting membrane (ILM). METHOD: The extent and intensity of traction of the epiretinal membrane (ERM) and the morphology of the individual retinal layers were investigated preoperatively in 14 eyes of 14 patients using three-dimensional HROCT (Cirrus prototype, scanned area 6x6 ...

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    14. Segmentation of the retinal pigment epithelium by polarization sensitive optical coherence tomography

      Christoph K. Hitzenberger, Erich Gotzinger, Michael Pircher et al. We report on a new method for segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous segmentation algorithms that were based on variations of backscattered intensity between individual layers, o ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684705 (2008)] published Mon Feb 18, 2008.
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    15. Die Rolle des Stratus-OCT bei der Anti-VEGF-Therapie

      Background The evaluation of OCT3 during anti-VEGF therapy. Methods A total of 29 patients with choroidal neovascularization secondary to AMD received 3 intravitreal injections of ranibizumab. OCT examination and visual acuity testing (ETDRS) were performed before therapy onset, after 1 week and after 1, 2 and 3 months. Results The central retinal thickness (CRT) was assessed correctly by OCT in 128 out of 145 measurements. There was a distinct (84%) but not significant correlation between decrease in central retinal thickness and increase in visual acuity. Incorrect retinal layer segmentation and inadequate CRT measurements were a significant technical limitation. Conclusion During ...

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    16. Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography

      Background/aims:A limited number of scans compromise conventional optical coherence tomography (OCT) to track chorioretinal disease in its full extension. Failures in edge-detection algorithms falsify the results of retinal mapping even further. High-definition-OCT (HD-OCT) is based on raster scanning and was used to visualise the localisation and volume of intra- and sub-pigment-epithelial (RPE) changes in fibrovascular pigment epithelial detachments (fPED). Two different scanning patterns were evaluated.Methods:22 eyes with fPED were imaged using a frequency-domain, high-speed prototype of the CirrusTM HD-OCT. The axial resolution was 6 µm, and the scanning speed was 25 kA scans/s. Two different ...

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    17. Intravitreal avastin for macular edmema secondary to retinal vein occlusion - a prospective study.

      Related Articles Intravitreal avastin for macular edmema secondary to retinal vein occlusion - a prospective study. Br J Ophthalmol. 2008 Jan 22; Authors: Kriechbaum K, Michels S, Prager F, Georgopoulos M, Funk M, Geitzenauer W, Schmidt-Erfurth U Abstract OBJECTIVE: To evaluate efficacy and safety of intravitreal bevacizumab (Avastin) in eyes with macular edema secondary to central (CRVO) or branch retinal vein occlusion (BRVO). METHODS: Twenty-eight consecutive patients (28 patients, 29 eyes, 8 CRVO, 21 BRVO) were enrolled in the study. Three intravitreal injections of 1 mg bevacizumab (0.04 ml) were administered at 4 week intervals; further retreatment was based on ...
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    1-17 of 17
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    Comparison of retinal thickness values and segmentation performance of different OCT devices in acute branch retinal vein occlusion Performance of Automated Drusen Detection by Polarization-sensitive Optical Coherence Tomography Reproducibility of High Resolution Optical Coherence Tomography Measurements of the Nerve Fiber Layer with the new Heidelberg Spectralis OCT Distortion and Instability Compensation with Deep Learning for Rotational Scanning Endoscopic Optical Coherence Tomography Laser-induced choroidal neovascularization detected on optical coherence tomography angiography in patients with diabetic retinopathy Optical coherence tomography- angiography: A new diagnostic and follow-up tool for glaucoma Corneal Irregular Astigmatism And Visual Function On Anterior Segment Optical Coherence Tomography In TGFBI Corneal Dystrophy Early-term Optical Coherence Tomography Angiographic Findings in Pediatric Patients Infected with COVID-19 Integrated deep learning framework for accelerated optical coherence tomography angiography The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy Automatic Assessment of Calcified Plaque and Nodule by Optical Coherence Tomography Adopting Deep Learning Mode Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity