1. Articles from anita mahadevan-jansen

    1-9 of 9
    1. Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin

      Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin

      Accurate depth assessment of burn wounds is a critical task to provide the right treatment and care. Currently, laser Doppler imaging is able to provide better accuracy compared to the standard clinical evaluation. However, its clinical applicability is limited by factors like scanning distance, time, and cost. Precise diagnosis of burns requires adequate structural and functional details. In this work, we evaluated the combined potential of two non-invasive optical modalities, optical coherence tomography (OCT) and Raman spectroscopy (RS), to identify degrees of burn wounds (superficial partial-thickness (SPT), deep partial-thickness (DPT), and full-thickness (FT)). OCT provides morphological information, whereas, RS provides ...

      Read Full Article
    2. Real-Time Identification of In Situ Pulmonary Nodule and Pathology Using Optical Coherence Tomography

      Real-Time Identification of In Situ Pulmonary Nodule and Pathology Using Optical Coherence Tomography

      The incidence of indeterminate pulmonary nodules (IPN) and ground glass opacities (GGO) is increasing. Small IPN may be difficult to localize in the operating room using a minimally invasive approach. Optical coherence tomography (OCT) utilizes interference of light waves to provide high-resolution, cross-sectional images of the internal microstructure by measuring back-reflected light. This approach can deliver video rate images of tissue structure on the micron scale and can be used to identify nodules and provide realtime histology-like images without actual removal of tissue to detect lung lesions.

      Read Full Article
    3. Common detector for combined raman spectroscopy-optical coherence tomography

      Common detector for combined raman spectroscopy-optical coherence tomography

      An apparatus includes first and second light sources for respectively generating broadband and monochromatic lights, a beamsplitter optically coupled to the first light source for splitting the broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, a sample arm optically coupled to the beamsplitter and the second light source for combining the sample and monochromatic lights, delivering the combined light to the target of interest, collecting a backscattering light and a Raman scattering light generated from interaction ...

      Read Full Article
    4. A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      Background and Objective The current standard for diagnosis of skin cancers is visual inspection followed by biopsy and histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions based on either morphological or biochemical features of disease. The objective of this work is to report a clinical instrument capable of both morphological and biochemical characterization of skin cancers with RS-OCT. Materials and Methods The portable instrument utilizes independent 785 nm RS and 1,310 nm OCT system backbones ...

      Read Full Article
    5. Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography

      Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography
      Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for optical analysis of tissues with mutually complementary strengths and limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay tissue biochemical composition but typically cannot relate microstructure. Previous implementations of combined RS-OCT have utilized a common sample arm while maintaining independent RS and OCT detection arms. We present the design and application of an integrated RS-OCT instrument with a common detection arm for both RS and OCT. The detector is a spectrograph capable of sequential detection of the 855-nm OCT signal and the ...
      Read Full Article
    6. Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

      Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

      Raman spectroscopy (RS) and Optical Coherence Tomography (OCT) are powerful tools for optical analysis of tissues with complimentary strengths. OCT excels and visualizing tissue microstructure while RS can relay tissue biochemical composition. Both instruments have significant potential to serve as valuable tools in non-invasive characterization of the rodent models of retinal disease. In this abstract we present the design and application of a common detector combined RS-OCT instrument for evaluating the morphological and biochemical differences in a rat model for oxygen induced retinopathy. Rat pups that have undergone a variable oxygen treatment are compared to rats raised in room air ...

      Read Full Article
    7. A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers

      A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers

      Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical instrument for morphological and biochemical characterization of skin cancers with combined RS-OCT. The portable instrument utilizes independent RS and OCT system backbones, and is integrated in a common clinical probe ...

      Read Full Article
    8. Combined raman spectroscopy-optical coherence tomography (RS-OCT) system and applications of the same

      An apparatus for evaluating a target of interest of a living subject. In one embodiment, the apparatus has a first light source for generating a broadband light, a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting it into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning it into the beamsplitter, and a probe having a working end placed proximal to a target of interest of a living subject, optically coupled ...

      Read Full Article
    9. Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

      Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

      We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis ...

      Read Full Article
    1-9 of 9
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (8 articles) Vanderbilt University
    2. (8 articles) Anita Mahadevan-Jansen
    3. (7 articles) Academic Medical Center at the University of Amsterdam
    4. (6 articles) Chetan A. Patil
    5. (6 articles) Ton G. van Leeuwen
    6. (3 articles) University of Twente
    7. (3 articles) Jeroen Kalkman
    8. (2 articles) Dirk J. Faber
    9. (1 articles) Nienke Bosschaart
    10. (1 articles) Institute of Applied Physics
    11. (1 articles) Medical University of Vienna
    12. (1 articles) Kyungpook National University
    13. (1 articles) Singapore Eye Research Institute
    14. (1 articles) University of Western Australia
    15. (1 articles) Stefan G. Sacu
    16. (1 articles) Brendan F. Kennedy
    17. (1 articles) Yongyang Huang
    18. (1 articles) Jeehyun Kim
    19. (1 articles) Ursula Schmidt-Erfurth
  3. Popular Articles

  4. Picture Gallery

    Combined Raman spectroscopy and optical coherence tomography device for tissue characterization A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT) Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers Common detector for combined raman spectroscopy-optical coherence tomography Real-Time Identification of In Situ Pulmonary Nodule and Pathology Using Optical Coherence Tomography Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin Full-range space-division multiplexing optical coherence tomography angiography Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis) Optical coherence tomography for characterization of nanocomposite materials (Thesis) In Vivo Corneal Microstructural Changes in Herpetic Stromal Keratitis: A Spectral-Domain Optical Coherence Tomography Analysis