1. Articles from Tien Y. Wong

    1-10 of 10
    1. Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure

      Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure

      Objective: A recent study found that a combination of 6 anterior segment optical coherence tomography (ASOCT) parameters (anterior chamber area, volume, and width [ACA, ACV, ACW], lens vault [LV], iris thickness at 750 μm from the scleral spur, and iris cross-sectional area) explain >80% of the variability in angle width. The aim of this study was to evaluate classification algorithms based on ASOCT measurements for the detection of gonioscopic angle closure.Design: Cross-sectional study.Participants: We included 2047 subjects aged ≥50 years.Methods: Participants underwent gonioscopy and ASOCT (Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou ...

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    2. Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Purpose. To determine the distribution, variation, and determinants of ganglion cell–inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (±SD) age of study subjects was 52.84 ± 6.14 ...

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    3. Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Purpose. To determine the distribution, variation and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in non-glaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. 623 Chinese adults aged 40-80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination and automated perimetry. HD-OCT (Cirrus, software version 6.0, Carl Zeiss Meditec, Dublin, CA) with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (± SD) age of study subjects ...

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    4. Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters

      Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters

      Objective To investigate the agreement between scanning laser ophthalmoscopy (Heidelberg retinal tomograph 3; HRT-3) and high-definition optical coherence tomography (HD–OCT) for measurements of optic nerve head (ONH) parameters. Methods As part of a population-based cross-sectional study, 913 consecutive Chinese subjects aged 40 years and older underwent HRT-3 and HD–OCT imaging of the ONH after pupillary dilation. Limits of agreement (LOA) derived from Bland–Altman analysis were calculated for ONH measurements. Results The mean age (±SD) of study participants was 54.2±7.2 years and 52.0% were men. The two instruments showed no difference in mean optic ...

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    5. Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects

      Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects
      Purpose: To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods: Adults aged 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. Cirrus high-definition OCT (Carl Zeiss Meditec Inc, Dublin, CA) was used to measure ONH and RNFL parameters. A total of 542 eyes from 542 non-glaucoma Chinese subjects were analyzed. Univariable and multiple linear regression analyses were performed to examine the effects of a range of ocular (e.g., intraocular pressure ...
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    6. Characteristics and appearance of the normal optic nerve head in 6-year-old children

      Characteristics and appearance of the normal optic nerve head in 6-year-old children
      Aim To document planimetric measures of normal optic nerve head parameters in 6-year-old children and to report prevalence and associations of common optic nerve signs. Methods The Sydney Childhood Eye Study examined 1765 children aged 6 years. Complete retinal photographs were available for 1225 participants, captured using a digital camera. Optical coherence tomography optic-disc measurements were acquired using the ‘fast’ optic-disc protocol. Statistical analyses were conducted using SAS version 9.1.3. Results The mean (95% CIs) planimetric optic-disc area was 2.29 mm2 (2.27 to 2.32), mean cup area 0.48 mm2 (0.47 to 0.50 ...
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    7. Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark

      Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark
      Objective To propose the Schwalbe line (SL) as a new anatomical landmark, independent of the scleral spur (SS) location, for assessing anterior chamber angle (ACA) width quantitatively with high-definition optical coherence tomography (HD-OCT). Methods Study subjects underwent dark-room gonioscopy and HD-OCT in one randomly selected eye. The authors developed a computer-aided program to define two new quantitative parameters for assessing ACA width: Schwalbe line-angle opening distance (SL-AOD) measured at the SL, and Schwalbe line-trabecular–iris space area (SL-TISA) measured 500 µm from the SL. The associations between SL parameters, SS parameters and gonioscopic grading were evaluated. Results Seventy-three (47 females ...
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    8. Influence of OCT Signal Strength on Macular, Optic Nerve Head and Retinal Nerve Fiber Layer Parameters

      Influence of OCT Signal Strength on Macular, Optic Nerve Head and Retinal Nerve Fiber Layer Parameters
      PURPOSE: To examine the influence of different signal strength on measurements made using optical coherence tomography (OCT) on macular, optic nerve head and retinal nerve fiber layer (RNFL) parameters. METHODS: 2092 children mostly aged 12 years were examined during 2003-5 and macular, optic nerve head and RNFL parameters were measured using Stratus OCT (Carl Zeiss, Dublin, CA). Multiple 'fast' scans were acquired and only right eyes were included in analyses. Signal strength category was determined after averaging individual signal strengths from each scan and classifying scans into 'moderate' (average signal strength between 5 and 7.49), 'good' (average signal strength ...
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    9. Macular and Nerve Fiber Layer Thickness in Amblyopia: The Sydney Childhood Eye Study

      Purpose: To examine macular and peripapillary retinal nerve fiber layer (RNFL) thickness in amblyopia.Design: Population-based cross-sectional study.Participants: Of 4118 children examined in the Sydney Childhood Eye Study (incorporating the Sydney Myopia Study) from 34 randomly selected primary schools and 21 secondary schools from 2003 to 2005, 3529 (85.7%) were included in this analysis. The median age of the 2 samples was 6 years (n = 1395) and 12 years (n = 2134), respectively.Methods: A detailed eye examination was conducted on all children, including determination of best-corrected visual acuity (logarithm of the minimum angle of resolution [logMAR]), autorefraction (RK-F1 ...
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    10. Relationship of Retinal Vascular Caliber with Optic Disc and Macular Structure

      Purpose To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). Design Observational cross-sectional study. Methods This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software. Results One hundred and four children (mean age 11.51 ± 0.52 years; 50% male) were included. In multivariate ...
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    1-10 of 10
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    1. (9 articles) National University of Singapore
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    Influence of OCT Signal Strength on Macular, Optic Nerve Head and Retinal Nerve Fiber Layer Parameters Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark Characteristics and appearance of the normal optic nerve head in 6-year-old children Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure Expectations and limitations of contemporary intravascular imaging: lessons learned from pathology Swept-source OCT and glaucoma Intra-operative OCT devices for ophthalmic use: an overview Simultaneously measuring the refractive index and thickness of an optical sample by using improved fiber-based optical coherence tomography