1. Articles from Kiriko Tomita

    1-2 of 2
    1. Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography

      Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography

      The zebrafish is a valuable vertebrate animal model in pre-clinical cancer research. A Jones matrix optical coherence tomography (JM-OCT) prototype operating at 1310 nm and an intensity-based spectral-domain OCT setup at 840 nm were utilized to investigate adult wildtype and a tumor-developing zebrafish model. Various anatomical features were characterized based on their inherent scattering and polarization signature. A motorized translation stage in combination with the JM-OCT prototype enabled large field-of-view imaging to investigate adult zebrafish in a non-destructive way. The diseased animals exhibited tumor-related abnormalities in the brain and near the eye region. The scatter intensity, the attenuation coefficients and ...

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    2. Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue

      Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue

      We demonstrate computational multi-directional optical coherence tomography (OCT) to assess the directional property of tissue microstructure. This method is the combination of phase-sensitive volumetric OCT imaging and post-signal processing. The latter comprises of two steps. The first step is an intensity-directional analysis, which determines the dominant en face fiber orientations. The second step is the phase-directional imaging, which reveals the sub-resolution depth-orientation of the microstructure. The feasibility of the method was tested by assessing muscle and tendon samples. Stripe patterns with several sizes were visualized in the phase-directional images. In order to interpret these images, the muscle and tendon structures ...

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    1-2 of 2
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    1. (2 articles) University of Tsukuba
    2. (1 articles) Medical University of Vienna
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