1. Articles from Jordan V. Wang

    1-3 of 3
    1. Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Background: Topical medications play a large role in the management of cutaneous diseases, but penetration is limited. Device-assisted drug delivery using mechanical destruction, lasers, and other energy-based modalities can increase penetration and absorption through creation of transcutaneous channels. Objective: To examine real-time, in vivo cutaneous changes in response to various devices used to improve topical drug delivery through optical coherence tomography (OCT) imaging. Methods and materials: Treatment was performed with 8 medical devices, including mechanical destruction, lasers, and other energy-based modalities. Optical coherence tomography was used for real-time, noninvasive, in vivo imaging. Results: Using OCT, microneedling and radiofrequency microneedling demonstrated ...

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      Mentions: UC Irvine
    2. Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Introduction: Port-wine birthmarks (PWBs) are congenital capillary malformations that can be located on any area of the body. Vascular features include vessel size, depth, and density, which can greatly differ between patients, individual lesions, and even sites within the same lesion. Previous studies have determined that the location of PWB lesions has impacted their clinical response to laser treatment. Objective: We utilized dynamic optical coherence tomography (D-OCT) to measure in vivo vessel diameter, density, and superficial plexus depth in patients of all ages with PWB on various sites of the body. We hypothesized that these vascular characteristics would differ according ...

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    3. Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Background: Port wine birthmarks (PWB) are congenital capillary malformations. Vessel characteristics, such as diameter and depth, may impact presentation and outcomes. They can be imaged using dynamic optical coherence tomography (D-OCT), a high-resolution, non-invasive imaging method. Purpose: We conducted a cross-sectional observational study to measure in-vivo vascular characteristics as a function of PWB color. Methods: Patients undergoing treatment for PWB were recruited from three sites. PWB were classified by color, and D-OCT images with calculations were obtained. Results: 108 patients were enrolled. Mean age correlated with PWB color, with younger patients having lighter and older patients having darker birthmarks (p ...

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    1-3 of 3
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    1. (3 articles) UC Irvine
    2. (2 articles) University of Miami
    3. (1 articles) Michelson Diagnostics
    4. (1 articles) University of Tokyo
    5. (1 articles) University College London
    6. (1 articles) University of Queensland
    7. (1 articles) University of Miami
    8. (1 articles) Topcon Medical Systems
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