1. Articles from Christopher G. Lui

    1-2 of 2
    1. Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

      Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

      After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1 week after noise exposure to determine if they ...

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    2. In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

      In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

      We describe an optical coherence tomography and vibrometry system designed for portable hand-held usage in the otology clinic on awake patients. The system provides clinically relevant point-of-care morphological imaging with 14-44 µm resolution and functional vibratory measures with sub-nanometer sensitivity. We evaluated various new approaches for extracting functional information including a multi-tone stimulus, a continuous chirp stimulus, and alternating air and bone stimulus. We also explored the vibratory response over an area of the tympanic membrane (TM) and generated TM thickness maps. Our results suggest that the system can provide real-time in vivo imaging and vibrometry of the ear and ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Southern California
    2. (1 articles) Northwestern University
    3. (1 articles) Jikei University School of Medicine
    4. (1 articles) Stanford University
    5. (1 articles) University of Pittsburgh
    6. (1 articles) Imperial College London
    7. (1 articles) Case Western Reserve University
    8. (1 articles) Pusan National University
    9. (1 articles) VU University Amsterdam
    10. (1 articles) University of Toronto
    11. (1 articles) Cleveland Clinic
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