1. Articles from Anselm Kampik

    1-12 of 12
    1. INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes

      INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes

      Purpose: To investigate the structural changes of intrapapillary proliferations associated with optic disk pits (ODPs) and optic disk pit maculopathy (ODP-M) using enhanced depth-spectral domain-optical coherence tomography (SD-EDI-OCT) and megahertz optical coherence tomography (MHz-OCT). Methods: Sixteen eyes of patients with ODPs were studied. Papillary and peripapillary areas were repeatedly examined with SD-EDI-OCT over time. To evaluate swept-source OCT, some of the patients additionally received MHz-OCT-imaging. Results: MHz-OCT or SD-EDI images showed the entire form of the pits from opening to bottom in 13 of the 16 cases. The shape of ODPs varied considerably. In patients with unilateral ODP, deep intrapapillary ...

      Read Full Article
    2. Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm

      Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm

      Purpose : To demonstrate ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s for choroidal imaging in normal and diseased eyes over a ∼60° field of view. To investigate and correlate wide-field three-dimensional (3D) choroidal thickness (ChT) and vascular patterns using ChT maps and coregistered high-definition en face images extracted from a single densely sampled Megahertz-OCT (MHz-OCT) dataset. Methods : High-definition, ∼60° wide-field 3D datasets consisting of 2088 × 1024 A-scans were acquired using a 1.68 MHz prototype SS-OCT system at 1050 nm based on a Fourier-domain mode-locked laser. Nine subjects (nine eyes) with various chorioretinal diseases or without ...

      Read Full Article
    3. Assessment of β-zone peripapillary atrophy by optical coherence tomography and scanning laser ophthalmoscopy imaging in glaucoma patients

      Assessment of β-zone peripapillary atrophy by optical coherence tomography and scanning laser ophthalmoscopy imaging in glaucoma patients

      Purpose: To assess β-zone peripapillary atrophy (β-PPA) using spectral domain optical coherence tomography (SD-OCT), scanning laser ophthalmoscopy (SLO), and fundus autofluorescence (FAF) imaging in patients with primary open-angle glaucoma with advanced glaucomatous visual field defects. Methods: A consecutive, prospective series of 82 study eyes with primary open-angle glaucoma were included in this study. All study participants underwent a full ophthalmic examination followed by SD-OCT, wide-field SLO, and FAF imaging of the optic nerve head and the peripapillary region. Results: Eighty-four glaucomatous eyes were included in our prospective study. Correlation analyses for horizontally and vertically obtained β-PPA for all three imaging ...

      Read Full Article
    4. Scanning laser ‘en face’ retinal imaging of epiretinal membranes

      Scanning laser ‘en face’ retinal imaging of epiretinal membranes

      Purpose Comparison of scanning laser ophthalmoscopy (SLO) based ‘en face’ imaging techniques of patients with epiretinal membranes (ERM) and evaluation of the accuracy of preoperative diagnostic imaging. Methods A consecutive, prospective series of 53 study eyes of 46 patients with clinically diagnosed and in optical coherence tomography (OCT) confirmed symptomatic ERMs were included in this study. Spectral domain (SD-) OCT volume scans (20° × 20° with 49 horizontal sections, ART 15) including SLO en face and fundus autofluorescence (FAF) images of the macula were obtained with HRA2 (Heidelberg Retina Angiograph-Optical Coherence Tomography, Heidelberg Engineering, Heidelberg, Germany). In addition, wide-field SLO color ...

      Read Full Article
    5. Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Background To investigate the image quality of wide-angle cross-sectional and reconstructed fundus images based on ultra-megahertz swept-source Fourier domain mode locking (FDML) OCT compared to current generation diagnostic devices. Methods A 1,050 nm swept-source FDML OCT system was constructed running at 1.68 MHz A-scan rate covering approximately 70° field of view. Twelve normal eyes were imaged with the device applying an isotropically dense sampling protocol (1,900 × 1,900 A-scans) with a fill factor of 100 %. Obtained OCT scan image quality was compared with two commercial OCT systems (Heidelberg Spectralis and Stratus OCT) of the same 12 eyes ...

      Read Full Article
    6. Multi-MHz retinal OCT

      Multi-MHz retinal OCT

      We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging of the human retina at A-scan rates in excess of 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line rates are investigated, and a simple multi-volume data processing approach is presented. In-vivo OCT of the human ocular fundus is performed at different axial scan rates of up to 6.7 MHz. High quality non-mydriatic retinal imaging over an ultra-wide field is achieved by a combination of several key improvements compared to previous setups. For the FDML laser ...

      Read Full Article
    7. Feature Of The Week 6/23/13: Ludwig Maximilian University of Munich Investigates Benefits of Joint Aperture Detection in Ophthalmic MHz OCT

      Feature Of The Week 6/23/13: Ludwig Maximilian University of Munich Investigates Benefits of Joint Aperture Detection in Ophthalmic MHz OCT

      Joint-aperture optical coherence tomography (JA-OCT) is an angle-resolved OCT method, in which illumination from an active channel is simultaneously probed by several passive channels. JA-OCT increases the collection efficiency and effective sensitivity of the OCT system without increasing the power on the sample. Additionally, JA-OCT provides angular scattering information about the sample in a single acquisition, so the OCT imaging speed is not reduced. Thus, JA-OCT is especially suitable for ultra high speed in-vivo imaging. JA-OCT is compared to other angle-resolved techniques, and the relation between joint aperture imaging, adaptive optics, coherent and incoherent compounding is discussed. We present angle-resolved ...

      Read Full Article
    8. Optimizing visualization in enhanced depth imaging OCT in healthy subjects and patients with retinal pigment epithelial detachment

      Optimizing visualization in enhanced depth imaging OCT in healthy subjects and patients with retinal pigment epithelial detachment

      Background: This study’s objective was to optimize the visualization of three different spectral-domain optical coherence tomography (SD-OCT) display modalities and evaluate enhanced depth imaging (EDI) by comparing the maximum depth of assessment in conventional versus inverted cross-sectional OCT images in healthy subjects and in patients with retinal pigment epithelial detachment (PED). Methods: Cross-sectional SD-OCT conventional and inverted images were obtained with the HRA2 (Heidelberg Retina Angiograph II, Heidelberg Engineering, Heidelberg, Germany). Horizontal as well as vertical sections in three different display modes were blinded for evaluation by three independent, experienced graders for maximal imaging depth of the deep ocular ...

      Read Full Article
    9. Feature Of The Week 9/4/11: Researchers at Ludwig-Maximilians University Continue to Blaze Trails Developing High Performance Swept Source OCT Technology and Its Application in Medical Imaging

      Feature Of The Week 9/4/11: Researchers at Ludwig-Maximilians University Continue to Blaze Trails Developing High Performance Swept Source OCT Technology and Its Application in Medical Imaging
      Researchers at Ludwig-Maximilians University continue to blaze trails in their work developing high performance swept source optical coherence tomography technology and the application of high speed frequency tuned sources in medical imaging. The Fourier-domain mode locked laser (FDML) together with tapped-delay line sweep-rate multipliers, light delivery and calibration optics, novel frame averaging and sampling techniques, wide FOV scanning technology, and high speed signal processing and visualization technology are impressive and will clearly have a significant impact on future medical imaging systems and ultimately patient care. Below is a presentation on some of their work entitled “(Multi-) MHz FDML OCT: Retinal ...
      Read Full Article
    10. In vivo characterization of ischemic retina in diabetic retinopathy

      In vivo characterization of ischemic retina in diabetic retinopathy
      Objective: The aim of this article is to characterize pathomorphologic changes within particular layers of fluorescein angiographically 'ischemic' compared to 'nonischemic' retina in patients with diabetic retinopathy. Methods: Cross-sectional images of ischemic retinal areas were obtained using Heidelberg Spectralis optical coherence tomography (OCT). Presumed retinal ischemia was defined as focal hypofluorescence in early or early and late phase fluorescein angiography. Pathomorphologic changes on OCT were evaluated and the thickness of retinal layers measured and compared with nonischemic retina at corresponding topographic locations in a matched-pairs design based on 22 eyes (mean age 64 ± 14). Results: In all eyes, based on ...
      Read Full Article
    11. Amadeus® II microkeratome: optimizing microkeratome settings for high flap accuracy using optical low coherence reflectometry

      Purpose. To investigate the impact of various experimental microkeratome settings and blade reuse on the accuracy of the flap thickness created with the new Amadeus® II microkeratome (SIS, Ziemer Ophthalmic, Port, Switzerland). Methods. In this prospective study, 120 porcine eyes were used to create corneal flaps with the Amadeus® II using 2 different cutting heads (140 µm, 160 µm) with the Surepass® blade. Using each blade twice, a head advance speed of 1.5 mm/s and 3.5 mm/s and oscillation rates of 8000 rpm, 10,000 rpm, and 13,000 rpm were used. Flap thickness was measured ...
      Read Full Article
    12. Optimizing the Deswelling Process of Organ-Cultured Corneas

      Purpose: During deswelling of organ-cultured human corneas, endothelial cell loss occurs. Therefore, it is necessary to minimize the deswelling time and achieving an optimal central corneal thickness (CCT) of approximately 550 [mu]m at the same time. We investigated the minimal deswelling time necessary and analyzed endothelial cell loss. Methods: Fifty-eight human corneas were stored between 13 and 81 days in organ culture. CCT was measured by optical coherence tomography. Measurements were performed before preparation, during culturing, before deswelling, and after varying deswelling periods (1-72 hours) using 5% dextran. Additionally, vital staining was performed in 6 human corneas to assess ...
      Read Full Article
    1-12 of 12
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (12 articles) Anselm Kampik
    2. (9 articles) Ludwig Maximilian University of Munich
    3. (9 articles) Aljoscha S. Neubauer
    4. (7 articles) Lukas Reznicek
    5. (6 articles) Robert A. Huber
    6. (6 articles) Wolfgang Wieser
    7. (5 articles) Heidelberg Engineering
    8. (4 articles) Thomas Klein
    9. (4 articles) Heidelberg Spectralis
    10. (2 articles) University of Lübeck
  3. Popular Articles

  4. Picture Gallery

    In vivo characterization of ischemic retina in diabetic retinopathy Feature Of The Week 9/4/11: Researchers at Ludwig-Maximilians University Continue to Blaze Trails Developing High Performance Swept Source OCT Technology and Its Application in Medical Imaging Optimizing visualization in enhanced depth imaging OCT in healthy subjects and patients with retinal pigment epithelial detachment Feature Of The Week 6/23/13: Ludwig Maximilian University of Munich Investigates Benefits of Joint Aperture Detection in Ophthalmic MHz OCT Multi-MHz retinal OCT Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices Scanning laser ‘en face’ retinal imaging of epiretinal membranes Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD) Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I An assessment of the quality of optical coherence tomography image acquisition Optical coherence tomography evaluation of vertebrobasilar artery stenosis: case series and literature review