OPTICAL COHERENCE TOMOGRAPHY FEATURES OF POLYPOIDAL LESION CLOSURE IN POLYPOIDAL CHOROIDAL VASCULOPATHY TREATED WITH AFLIBERCEPT

Purpose: To evaluate whether optical coherence tomography (OCT) can determine polypoidal lesion (PL) perfusion in polypoidal choroidal vasculopathy (PCV) eyes following 12-months of aflibercept monotherapy. PL perfusion status, assessed by indocyanine green angiography (ICGA), is an important anatomical outcome in PCV management. Methods: Post-hoc data from a prospective randomised, open-label, study in eyes with PCV undergoing monotherapy with aflibercept evaluated PL perfusion status based on ICGA (gold standard) and OCT features from baseline to 12-months. Results: Individual PLs(110 in total) from 48 eyes(48 patients) showed at 12-months, 57/110 PLs(51.8%) were closed on ICGA. At 12-months ...