1. Articles from Robert Zivadinov

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    1. Serum neurofilament light chain and optical coherence tomography measures in MS: A longitudinal study

      Serum neurofilament light chain and optical coherence tomography measures in MS: A longitudinal study

      Objective To study the association between serum neurofilament light chain (sNfL) and multiple optical coherence tomography (OCT) measures in patients with MS and healthy controls (HCs). Methods In this prospective study, 110 patients with MS were recruited, together with 52 age- and sex-matched HCs. Clinical evaluation and spectral domain OCT and sNfL were obtained at baseline and after 5.5 years of follow-up. Nested linear mixed models were used to assess differences between MS vs HC and associations between sNfL and OCT measures. Partial correlation coefficients are reported, and p values were adjusted for the false discovery rate. Results At ...

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    2. The Effect of Glatiramer Acetate on Retinal Nerve Fiber Layer Thickness in Patients with Relapsing–Remitting Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

      The Effect of Glatiramer Acetate on Retinal Nerve Fiber Layer Thickness in Patients with Relapsing–Remitting Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

      Background Optical coherence tomography (OCT) is a technique that allows for the assessment of retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV), which reflect neuroaxonal integrity within the retina. As such it has been used in multiple sclerosis (MS) to study neurodegeneration. Glatiramer acetate (GA) is a widely used treatment for MS, which is suggested to have a possible neuroprotective role. Objective The aim of this study was to assess RFNLT and TMV changes in relapsing–remitting MS (RRMS) patients who started treatment with GA and were followed for a 24-month period. Methods A cohort of 60 ...

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    3. Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?

      Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?

      Central nervous system (CNS) pathologies have ocular manifestations due to direct and/or retrograde degeneration of the visual pathways, most often related to a direct injury to the optic nerve, retinal ganglion cells and/or its surrounding cells. These ocular manifestations can be recognized and monitored by a non-invasive technique called Optical Coherence Tomography (OCT). OCT helps in the measurement of retinal nerve fiber layer (RNFL) thickness and macular thickness which consists of retinal ganglion cells. OCT provides a near-histological level of image resolution up to 5µm by using principles of interferometry that can detect CNS inflammatory, as well ...

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    4. Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

      BackgroundMeasurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention.ObjectivesTo explore the relationship between RNFL thickness as measured by optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx), and conventional and non-conventional optic nerve and brain MRI measures.MethodsTwelve relapsing–remitting (RR) MS patients (12 affected and 12 unaffected eyes) and 4 age- and sex-matched normal controls (NC) (8 unaffected eyes) were enrolled. Four MS patients had a history of bilateral optic neuritis (ON), four had a history of unilateral ON, and 4 had no history of ON. Optic ...

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    1-4 of 4
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    1. (2 articles) Bianca Weinstock-Guttman
    2. (1 articles) University of Pennsylvania
    3. (1 articles) Johns Hopkins University
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    Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain? The Effect of Glatiramer Acetate on Retinal Nerve Fiber Layer Thickness in Patients with Relapsing–Remitting Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study Serum neurofilament light chain and optical coherence tomography measures in MS: A longitudinal study Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study Short-term healing response after implantation of the thin-strut, fast-releasing sirolimus-eluting biodegradable polymer-coated Alex Plus stent: optical coherence tomography study Connector sensors for permittivity-based thrombus monitoring in extracorporeal life support Optical Coherence Tomography Angiography for Mapping Cerebral Microvasculature Based on Normalized Differentiation Analysis Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function Comparison of post-stent irregular protrusion and subsequent neointimal characteristics between second- and third-generation drug-eluting stent implantation