1. Articles from Yirui Zhu

    1-5 of 5
    1. Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography

      Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography

      Biomechanical properties of corneal scar are strongly correlated with many corneal diseases and some types of corneal surgery, however, there is no elasticity information available about corneal scar to date. Here, we proposed an acoustic radiation force optical coherence elastography system to evaluate corneal scar elasticity. Elasticity quantification was first conducted on ex vivo rabbit corneas, and the results validate the efficacy of our system. Then, experiments were performed on an ex vivo human scarred cornea, where the structural features, the elastic wave propagations, and the corresponding Young's modulus of both the scarred region and the normal region were ...

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    2. A preliminary study of shaker-based optical coherence elastography for assessment of gingival elasticity

      A preliminary study of shaker-based optical coherence elastography for assessment of gingival elasticity

      Studies on the changes in biomechanical properties of the gingiva are significant, since they are closely related to the pathological process of gingivitis and periodontitis. Although some research has been conducted, the currently used techniques are not feasible for in vivo and clinical measurements due to their disadvantages, such as the invasive nature and the requirement of thin sectioning. In this study, we developed a shaker-based optical coherence elastography system which provides noninvasive measurement, high axial resolution, high displacement sensitivity, and real-time imaging, and explored its potential for the detection of gingival elasticity. The system was tested by an agar ...

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    3. 1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study

      1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study

      Optical coherence tomography (OCT) is a non-invasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7-micron OCT/OCT angiography (OCTA) system that allows for a visualization of both morphology and microvasculature in the deeper layers of the skin. Using this imaging system, we imaged human skin with different benign lesions and described the corresponding features of both structure and ...

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      Mentions: UC Irvine
    4. Use of spectral domain optical coherence tomography to detect internal defects of resin composites in carious teeth after restorations

      Use of spectral domain optical coherence tomography to detect internal defects of resin composites in carious teeth after restorations

      Postoperative testing plays an important role in evaluating clinical effect of treatment of caries by filling the decayed teeth with resin composites, which mainly depends on the detection of defects at the interface between resin composites and cavity to date, without considering the internal defects of resin composites. Here, we report, for the first time, the measurement of the morphologies within resin composites by using spectral domain optical coherence tomography. Experiments were performed on the ex vivo human carious teeth after restorations, and the results showed that the tiny cracks and air bubbles within resin composites can be clearly distinguished ...

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    5. Quantification of iris elasticity using acoustic radiation force optical coherence elastography

      Quantification of iris elasticity using acoustic radiation force optical coherence elastography

      Careful quantification of the changes in biomechanical properties of the iris can offer insight into the pathophysiology of some ocular diseases. However, to date there has not been much information available regarding this subject because clinical detection for iris elasticity remains challenging. To overcome this limitation, we explore, for the first time to our knowledge, the potential of measuring iris elasticity using acoustic radiation force optical coherence elastography (ARF-OCE). The resulting images and shear wave propagation, as well as the corresponding shear modulus and Young’s modulus from ex vivo and in vivo rabbit models confirmed the feasibility of this ...

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    1-5 of 5
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  2. Topics in the News

    1. (1 articles) UC Irvine
    2. (1 articles) Capital Medical University
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    Quantification of iris elasticity using acoustic radiation force optical coherence elastography Use of spectral domain optical coherence tomography to detect internal defects of resin composites in carious teeth after restorations 1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study A preliminary study of shaker-based optical coherence elastography for assessment of gingival elasticity Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography Microperimetry, Humphrey field analyzer, and optical coherence tomography in detecting glaucoma: a comparative performance study Scanning optimization of an electrothermally-actuated MEMS mirror for applications in optical coherence tomography endoscopy