1. Articles from Liang Xu

    1-14 of 14
    1. Using spectral-domain optical coherence tomography to evaluate the type and thickness of interdigitation zone band in adult Chinese

      Using spectral-domain optical coherence tomography to evaluate the type and thickness of interdigitation zone band in adult Chinese

      To study types and thickness of interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of interdigitation zone band. There are two types of interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which ...

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    2. Optical Coherence Tomography Angiography Vessel Density Changes after Acute Intraocular Pressure Elevation

      Optical Coherence Tomography Angiography Vessel Density Changes after Acute Intraocular Pressure Elevation

      To investigate changes in retinal vessel density in optic nerve head (ONH) and macula after acute intraocular pressure (IOP) elevation, we conducted a prospective observational study. Eyes with IOP rise ≥5 mmHg after 2-hour dark room prone provocative test (DRPPT) were included. Vasculature of ONH and macula was examined by optical coherence tomography angiography (OCTA) at baseline and after DRPPT. Among the 65 eyes of 42 individuals, 40 eyes with qualified images were enrolled. Mean IOP rise was 9.6 ± 4.2 mmHg (5.0–23.3 mmHg) after DRPPT. Retinal vessel density did not differ after IOP rise for ...

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    3. Comparison of long-term in-stent vascular response between abluminal groove-filled biodegradable polymer sirolimus-eluting stent and durable polymer everolimus-eluting stent: 3-year OCT follow-up from the TARGET I trial

      Comparison of long-term in-stent vascular response between abluminal groove-filled biodegradable polymer sirolimus-eluting stent and durable polymer everolimus-eluting stent: 3-year OCT follow-up from the TARGET I trial

      The study sought to compare long-term optical coherence tomography (OCT)-based in-stent vascular response between the abluminal groove-filled biodegradable polymer sirolimus-eluting stent (SES) and the durable polymer everolimus-eluting stent (EES) in the TARGET I trial. The TARGET I trial was a prospective, multicenter, randomized clinical trial which enrolled 458 patients with single de novo lesions treated by abluminal groove-filled biodegradable polymer SES and EES. A subset of 43 patients underwent angiography and OCT examinations at 3 years. All OCT images were analyzed at 0.4 mm intervals. A similar increase in angiographic late lumen loss was observed in SES and ...

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    4. Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study

      Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study

      Purpose The aim of this study was to measure retinal nerve fibre layer thickness (RNFLT) and its associated factors in a population-based setting. Methods The population-based Beijing Eye Study 2011 included 3468 individuals. The study participants underwent spectral-domain optical coherence tomography (Spectralis ® ; Spectralis OCT)–assisted measurement of the RNFLT. For this study, exclusion criteria were glaucoma, pseudoexfoliation, best-corrected visual acuity of >0.5 logMAR, macular diseases, previous ocular surgery and known neurological diseases. The only inclusion criterion was an age of 50+ years. Results The inclusion criteria were fulfilled by 2548 participants. Mean RNFLT was 102 ± 11 μm. RNFLT was ...

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    5. Localized Retinal Nerve Fiber Layer Defects Detected by Optical Coherence Tomography: The Beijing Eye Study

      Localized Retinal Nerve Fiber Layer Defects Detected by Optical Coherence Tomography: The Beijing Eye Study

      Objective To assess the prevalence of localized retinal nerve fiber layer defects (LRNFLD) and associated factors in adult Chinese. Methods The population-based Beijing Eye Study 2011 included 3468 individuals (mean age: 64.6±9.8 years (range: 50–93 years)). The study participants underwent a detailed ophthalmological examination including spectral-domain optical coherence tomography (Spectralis R -OCT) assisted measurement of the RNFL. A LRNFLD was defined as a sector in which the RNFL contour line dipped into the red zone for a length of <180°. Results Readable OCT images were available for 3242 (93.5%) subjects. LRNFLDs were detected in 640 ...

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    6. Myopic Maculopathy Imaged by Optical Coherence Tomography: The Beijing Eye Study

      Myopic Maculopathy Imaged by Optical Coherence Tomography: The Beijing Eye Study

      Purpose To examine the features of myopia-related optical coherence tomography (OCT) findings in a population-based setting. Design Population-based study. Participants The Beijing Eye Study 2011 included 3468 subjects with an age of 50 years or more. Methods The participants underwent a detailed ophthalmic examination including OCT with enhanced depth imaging of the macula. Main Outcome Measures Optical coherence tomography features of the macula in highly myopic eyes defined by a refractive error of −6 diopters or less or an axial length of 26.5 mm or more. Results Readable OCT images were available for 6530 eyes (94.5%) of 3278 ...

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    7. Feature Of The Week 11/11/12: Characterization of Coronary Bifurcations using Optical Coherence Tomography

      Feature Of The Week 11/11/12: Characterization of Coronary Bifurcations using Optical Coherence Tomography

      Correct characterization of coronary bifurcations by optical coherence tomography (OCT) is critical in the evaluation of lesions, dedicated bifurcation stents and stent techniques. Assessment is limited by the need for acquiring images in both the main branch (MB) and the dissection prone side branch (SB). Analysis poses the significant risk of OCT cross sections not being perpendicular to the true vessel centerline due to imaging wires being non-parallel to the centerline. Correct measurements in tortuous vessels and ostia are particularly sensitive to the non-parallel wire problem and to the actual measurement plane, independent of whether a MB or a SB ...

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    8. In vivo comparison of arterial lumen dimensions assessed by co-registered three-dimensional (3D) quantitative coronary angiography, intravascular ultrasound and optical coherence tomography

      In vivo comparison of arterial lumen dimensions assessed by co-registered three-dimensional (3D) quantitative coronary angiography, intravascular ultrasound and optical coherence tomography

      This study sought to compare lumen dimensions as assessed by 3D quantitative coronary angiography (QCA) and by intravascular ultrasound (IVUS) or optical coherence tomography (OCT), and to assess the association of the discrepancy with vessel curvature. Coronary lumen dimensions often show discrepancies when assessed by X-ray angiography and by IVUS or OCT. One source of error concerns a possible mismatch in the selection of corresponding regions for the comparison. Therefore, we developed a novel, real-time co-registration approach to guarantee the point-to-point correspondence between the X-ray, IVUS and OCT images. A total of 74 patients with indication for cardiac catheterization were ...

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    9. Reproducibility of Subfoveal Choroidal Thickness Measurements with Enhanced Depth Imaging By Spectral-Domain Optical Coherence Tomography

      Reproducibility of Subfoveal Choroidal Thickness Measurements with Enhanced Depth Imaging By Spectral-Domain Optical Coherence Tomography

      Purpose: To measure the interobserver reproducibility and intraobserver reproducibility of subfoveal choroidal thickness measurements performed by enhanced depth imaging of spectral-domain optical coherence tomography (EDI-OCT) in a population-based setting. Method: The Beijing Eye Study 2011 was a population-based study performed in rural and urban regions of Greater Beijing. The study included 3468 individuals with a mean age of 64.6±9.8 years (range: 50-93 years). The participants underwent EDI-OCT and the subfoveal choroidal thickness (SFCT) was measured. To examine the inter-observer variability, all images were assessed by two examiners independently of each other within 2 months. To examine the ...

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    10. Cotton-Wool Spot and Optical Coherence Tomography of a Retinal Nerve Fiber Layer Defect

      Cotton-Wool Spot and Optical Coherence Tomography of a Retinal Nerve Fiber Layer Defect

      A 53-year-old woman with severe arterial hypertension was concerned about flashes and a shadow in her left eye. Perimetry revealed an arc-shaped visual field defect in the superior hemisphere. Ophthalmoscopy showed a large cotton-wool spot inferior of the optic disc (Figure 1, above). Optical coherence tomography showed an edema of the retinal nerve fiber layer in the area of the cotton-wool spot. One year later, perimetry was unchanged. On ophthalmoscopy, an inferior wedge-shaped defect of the retinal nerve fiber layer was detected (Figure 2A, right, white arrows), while the cotton-wool spot completely vanished. Optical coherence tomography revealed a marked reduction ...

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    11. Agreement Between Spectral Domain Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography in Chinese

      Agreement Between Spectral Domain Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography in Chinese

      Purpose: To compare spectral domain optical coherence tomography (OCT) and fundus photography to identify localized retinal nerve fiber layer defects (RNFLD) in Chinese patients with early-to-medium advanced glaucoma. Methods: Thirty-nine patients (48 eyes) with localized RNFLDs by fundus photography and 48 age-matched control individuals were included into the study. The individuals underwent spectral domain OCT of the retinal nerve layer. In OCT, a localized RNFLD was defined as a dipping of the retinal nerve fiber layer thickness curve into the red-colored band of the graph, measured at a peripapillary circle with a diameter of 3.46 mm. Results: In the ...

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    12. Anterior segment optical coherence tomography of acute primary angle closure

      Anterior segment optical coherence tomography of acute primary angle closure
      Background To assess anterior segment optical coherence tomographic measurements of patients after acute unilateral primary angle closure (APAC) compared with those of normal subjects. Methods The clinical observational study included 41 hospital-based patients after unilateral APAC, their unaffected contralateral eyes, and 205 subjects. These were selected from the population-based Beijing Eye Study, and were matched with the APAC group for age, gender, and refractive error. All study participants underwent slit-lamp adapted optical coherence tomography (OCT). Results Compared with the unaffected contralateral eyes, eyes with APAC had a significantly shallower anterior chamber (P < 0.001), smaller chamber angle (P < 0.001 ...
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    13. The Beijing Eye Study

      Purpose: This review presents and summarizes the findings of the Beijing Eye Study. Methods: The Beijing Eye Study is a population-based study which included 4439 of 5324 subjects (aged ≥ 40 years) who were initially examined in 2001. The study was repeated in 2006, when 3251 (73.2% of 4439, or 61.1% of 5324) of the original subjects participated. Participants underwent a series of examinations including: refractometry; pneumotonometry; biomicroscopy assisted by slit-lamp; optical coherence tomography of the anterior segment; photography of the cornea, lens, optic disc, macula and fundus; blood sampling for laboratory tests; blood pressure measurements, and determinations of ...
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    14. Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study

      Abstract Background  To evaluate the distribution of central corneal thickness and its associations in the adult Chinese population. Methods  The Beijing Eye Study 2006 is a population-based study including 3,251 (73.3%) subjects (aged 45+ years) out of 4,439 subjects who participated in the survey in 2001 and who returned for re-examination. Central corneal thickness (CCT) measurements were performed by slit lamp-based optical coherence tomography. Results  Central corneal thickness measurement data were available for 3,100 (95.4%) subjects. Mean CCT was 556.2±33.1 μm (median: 553 μm; range: 429–688 μm). In multiple regression analysis ...
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    1-14 of 14
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    1. (9 articles) Jost B. Jonas
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    Anterior segment optical coherence tomography of acute primary angle closure Agreement Between Spectral Domain Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography in Chinese Cotton-Wool Spot and Optical Coherence Tomography of a Retinal Nerve Fiber Layer Defect Reproducibility of Subfoveal Choroidal Thickness Measurements with Enhanced Depth Imaging By Spectral-Domain Optical Coherence Tomography In vivo comparison of arterial lumen dimensions assessed by co-registered three-dimensional (3D) quantitative coronary angiography, intravascular ultrasound and optical coherence tomography Feature Of The Week 11/11/12: Characterization of Coronary Bifurcations using Optical Coherence Tomography Localized Retinal Nerve Fiber Layer Defects Detected by Optical Coherence Tomography: The Beijing Eye Study Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study Impact of Optical Coherence Tomography Imaging on Decision-Making During Percutaneous Coronary Intervention in Patients Presented With Acute Coronary Syndromes Time course of collateral vessel formation after retinal vein occlusion visualized by OCTA and elucidation of factors in their formation Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Changes on Optical Coherence Tomography in Patients with Unilateral Hypertensive Cytomegalovirus Anterior Uveitis