1. Articles from alex e. cable

    25-34 of 34 « 1 2
    1. Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT

      Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT

      Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain OCT for visualization and quantitative assessment of retinal blood flow. Using swept laser technology, the system operated in the 1050-nm wavelength range at a high axial scan rate of 200 kHz. The rapid imaging speed not only enables volumetric imaging with high axial scan densities, but also enables measurement of high flow velocities in the central retinal vessels. Deep penetration in the optic nerve and lamina cribrosa was achieved by imaging at 1-µm wavelengths. By analyzing en-face images extracted ...

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    2. Optical coherence tomography imaging system and method

      Optical coherence tomography imaging system and method
      An optical imaging system includes an optical radiation source (410, 510), a frequency clock module outputting frequency clock signals (420), an optical interferometer (430), a data acquisition (DAQ) device (440) triggered by the frequency clock signals, and a computer (450) to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source (410, 510) to trigger the sampling process of the DAQ device (440). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further ...
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      Mentions: Thorlabs
    3. Optical coherence tomography for the quantitative study of cerebrovascular physiology

      Optical coherence tomography for the quantitative study of cerebrovascular physiology

      Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

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    4. Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second

      Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second
      We demonstrate ultrahigh speed swept source/Fourier domain ophthalmic OCT imaging using a short cavity swept laser at 100,000 - 400,000 axial scan rates. Several design configurations illustrate tradeoffs in imaging speed, sensitivity, axial resolution, and imaging depth. Variable rate A/D optical clocking is used to acquire linear-in-k OCT fringe data at 100kHz axial scan rate with 5.3um axial resolution in tissue. Fixed rate sampling at 1 GSPS achieves a 7.5mm imaging range in tissue with 6.0um axial resolution at 100kHz axial scan rate. A 200kHz axial scan rate with 5.3um axial resolution over ...
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    5. Rapid volumetric angiography of cortical microvasculature with optical coherence tomography

      Rapid volumetric angiography of cortical microvasculature with optical coherence tomography

      We describe methods and algorithms for rapid volumetric imaging of cortical vasculature with optical coherence tomography (OCT). By optimizing system design, scanning protocols, and algorithms for visualization of capillary flow, comprehensive imaging of the surface pial vasculature and capillary bed is performed in approximately 12 s. By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated.

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    6. Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography

      Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography
      Feature Of The Week 9/6/09: Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue morphology in situ and in real-time. Recent development in high-speed OCT enables the acquisition of a large amount of three-dimensional image d
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    7. AN OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND METHOD (WO 2008/089393)

      AN OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND METHOD (WO 2008/089393)
      An optical imaging system includes an optical radiation source (410, 510), a frequency clock module outputting frequency clock signals (420), an optical interferometer (430), a data acquisition (DAQ) device (440) triggered by the frequency clock signals, and a computer (450) to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source (410, 510) to trigger the sampling process of the DAQ device (440). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further ...
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      Mentions: Thorlabs
    8. Speckle variance detection of microvasculature using swept-source optical coherence tomography

      Speckle variance detection of microvasculature using swept-source optical coherence tomography
      Adrian Mariampillai, Beau A. Standish, Eduardo H. Moriyama, Mamta Khurana, Nigel R. Munce, Michael K. Leung, James Jiang, Alex Cable, Brian C. Wilson, I. Alex Vitkin, Victor X. Yang. We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT ... [Opt. Lett. 33, 1530-1532 (2008)]
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    9. High-resolution optical coherence tomography imaging of the living kidney

      Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can provide non-invasive, cross-sectional, high-resolution images of tissue morphology in situ and in real-time. In the present series of studies, we used a high-speed OCT imaging system equipped with a frequency-swept laser light source (1.3 m wavelength) to study living kidneys in situ. Adult, male Munich–Wistar rats were anesthetized, a laparotomy was performed and the living kidneys were exposed for in situ observation. We observed the kidneys prior to, during and following exposure to renal ischemia induced by clamping the renal artery. The effects of intravenous mannitol ...
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    10. Comparison of three-dimensional optical coherence tomography and high resolution photography for art conservation studies

      Gold punchwork and underdrawing in Renaissance panel paintings are analyzed using both three-dimensional swept source / Fourier domain optical coherence tomography (3D-OCT) and high resolution digital photography. 3D-OCT can generate en face images with micrometer-scale resolutions at arbitrary ... [Opt. Express 15, 15972-15986 (2007)]
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    25-34 of 34 « 1 2
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    Speckle variance detection of microvasculature using swept-source optical coherence tomography Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography Rapid volumetric angiography of cortical microvasculature with optical coherence tomography Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second Optical coherence tomography for the quantitative study of cerebrovascular physiology Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast MEMS tunable VCSEL light source for ultrahigh speed 60kHz - 1MHz axial scan rate and long range centimeter class OCT imaging 1065nm and 1310nm MEMS tunable VCSEL light source technology for OCT imaging Optical coherence tomography findings after surgery for sub-inner limiting membrane hemorrhage due to ruptured retinal arterial macroaneurysm Changes in macrophage-like cells characterized by en face optical coherence tomography after retinal stroke Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance