1. Articles from james y. jiang

    1-11 of 11
    1. Statistical intensity variation analysis for rapid volumetric imaging of capillary network flux

      Statistical intensity variation analysis for rapid volumetric imaging of capillary network flux

      We present a novel optical coherence tomography (OCT)-based technique for rapid volumetric imaging of red blood cell (RBC) flux in capillary networks. Previously we reported that OCT can capture individual RBC passage within a capillary, where the OCT intensity signal at a voxel fluctuates when an RBC passes the voxel. Based on this finding, we defined a metric of statistical intensity variation (SIV) and validated that the mean SIV is proportional to the RBC flux [RBC/s] through simulations and measurements. From rapidly scanned volume data, we used Hessian matrix analysis to vectorize a segment path of each capillary ...

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    2. Dynamic light scattering optical coherence tomography

      Dynamic light scattering optical coherence tomography

      We introduce an integration of dynamic light scattering (DLS) and optical coherence tomography (OCT) for high-resolution 3D imaging of heterogeneous diffusion and flow. DLS analyzes fluctuations in light scattered by particles to measure diffusion or flow of the particles, and OCT uses coherence gating to collect light only scattered from a small volume for high-resolution structural imaging. Therefore, the integration of DLS and OCT enables high-resolution 3D imaging of diffusion and flow. We derived a theory under the assumption that static and moving particles are mixed within the OCT resolution volume and the moving particles can exhibit either diffusive or ...

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    3. 1065nm and 1310nm MEMS tunable VCSEL light source technology for OCT imaging

      1065nm and 1310nm MEMS tunable VCSEL light source technology for OCT imaging

      A novel vertical-cavity surface-emitting laser with a microelectromechanical tuning element enables high-speed, centimeter-range optical coherence tomography. Optical coherence tomography (OCT) is a noninvasive optical imaging technique that can generate micron-resolution 2D and 3D images of tissue and other scattering materials.1 First demonstrated for imaging the human eye and coronary arteries in 1991,1 OCT has become a clinical standard for diagnosing and monitoring treatment of eye disease, with approximately 16 million ophthalmic OCT procedures performed in the US in 2010.2 OCT can also be used for intravascular imaging of plaque to assess heart disease, cancer biopsy imaging, developmental ...

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    4. OCT methods for capillary velocimetry

      OCT methods for capillary velocimetry

      To date, two main categories of OCT techniques have been described for imaging hemodynamics: Doppler OCT and OCT angiography. Doppler OCT can measure axial velocity profiles and flow in arteries and veins, while OCT angiography can determine vascular morphology, tone, and presence or absence of red blood cell (RBC) perfusion. However, neither method can quantify RBC velocity in capillaries, where RBC flow is typically transverse to the probe beam and single-file. Here, we describe new methods that potentially address these limitations. Firstly, we describe a complex-valued OCT signal in terms of a static scattering component, dynamic scattering component, and noise ...

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    5. Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

      Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

      In vivo optical microscopic imaging techniques have recently emerged as important tools for the study of neurobiological development and pathophysiology. In particular, two-photon microscopy has proved to be a robust and highly flexible method for in vivo imaging in highly scattering tissue. However, two-photon imaging typically requires extrinsic dyes or contrast agents, and imaging depths are limited to a few hundred microns. Here we demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of neuronal cell bodies and cortical myelination up to depths of ~1.3 mm in the rat neocortex. Imaging does not require the administration of exogenous dyes ...

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    6. Optical coherence tomography imaging system and method

      Optical coherence tomography imaging system and method
      An optical imaging system includes an optical radiation source (410, 510), a frequency clock module outputting frequency clock signals (420), an optical interferometer (430), a data acquisition (DAQ) device (440) triggered by the frequency clock signals, and a computer (450) to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source (410, 510) to trigger the sampling process of the DAQ device (440). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further ...
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    7. Optical coherence tomography for the quantitative study of cerebrovascular physiology

      Optical coherence tomography for the quantitative study of cerebrovascular physiology

      Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

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    8. Rapid volumetric angiography of cortical microvasculature with optical coherence tomography

      Rapid volumetric angiography of cortical microvasculature with optical coherence tomography

      We describe methods and algorithms for rapid volumetric imaging of cortical vasculature with optical coherence tomography (OCT). By optimizing system design, scanning protocols, and algorithms for visualization of capillary flow, comprehensive imaging of the surface pial vasculature and capillary bed is performed in approximately 12 s. By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated.

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    9. Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography

      Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography
      Feature Of The Week 9/6/09: Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue morphology in situ and in real-time. Recent development in high-speed OCT enables the acquisition of a large amount of three-dimensional image d
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    10. AN OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND METHOD (WO 2008/089393)

      AN OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND METHOD (WO 2008/089393)
      An optical imaging system includes an optical radiation source (410, 510), a frequency clock module outputting frequency clock signals (420), an optical interferometer (430), a data acquisition (DAQ) device (440) triggered by the frequency clock signals, and a computer (450) to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source (410, 510) to trigger the sampling process of the DAQ device (440). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further ...
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    11. Comparison of three-dimensional optical coherence tomography and high resolution photography for art conservation studies

      Gold punchwork and underdrawing in Renaissance panel paintings are analyzed using both three-dimensional swept source / Fourier domain optical coherence tomography (3D-OCT) and high resolution digital photography. 3D-OCT can generate en face images with micrometer-scale resolutions at arbitrary ... [Opt. Express 15, 15972-15986 (2007)]
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    1-11 of 11
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  2. Topics in the News

    1. (11 articles) James Y. Jiang
    2. (11 articles) Thorlabs
    3. (9 articles) Alex E. Cable
    4. (6 articles) Harvard University
    5. (6 articles) Massachusetts General Hospital
    6. (4 articles) Massachusetts Institute of Technology
    7. (4 articles) Vivek J. Srinivasan
    8. (4 articles) Harsha Radhakrishnan
    9. (4 articles) David A. Boas
    10. (2 articles) James G. Fujimoto
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    AN OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND METHOD (WO 2008/089393) Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography Rapid volumetric angiography of cortical microvasculature with optical coherence tomography Optical coherence tomography for the quantitative study of cerebrovascular physiology Optical coherence tomography imaging system and method Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast OCT methods for capillary velocimetry 1065nm and 1310nm MEMS tunable VCSEL light source technology for OCT imaging Statistical intensity variation analysis for rapid volumetric imaging of capillary network flux AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography Motorized capsule for shadow-free OCT imaging and synchronous beam control Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests