1. Articles from junya shite

    25-44 of 44 « 1 2
    1. Qualitative and Quantitative Assessment of Stent Restenosis by Optical Coherence Tomography

      Qualitative and Quantitative Assessment of Stent Restenosis by Optical Coherence Tomography

      We hypothesized that the tissue components of in-stent restenosis (ISR) might differ between drug-eluting stents (DES) and bare-metal stents (BMS) and that these differences could be distinguished by qualitative and quantitative optical coherence tomography (OCT) analyses. Methods and Results:  One-hundred and twenty-two initial ISR lesions (sirolimus-eluting stents: n=28; paclitaxel-eluting stents: n=51; BMS: n=43) were evaluated with OCT. Based on their OCT appearance, the lesions were classified as homogeneous, layered or heterogeneous. The optical properties of backscatter, attenuation and signal intensity of the neointimal tissue (NIT) were quantified. To evaluate the vascular response after balloon angioplasty (BA), the ...

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    2. Effect of Cytochrome P450 2C19 Polymorphism on Target Lesion Outcome After Drug-Eluting Stent Implantation in Japanese Patients Receiving Clopidogrel

      Effect of Cytochrome P450 2C19 Polymorphism on Target Lesion Outcome After Drug-Eluting Stent Implantation in Japanese Patients Receiving Clopidogrel

      Background: Cytochrome P450 (CYP) 2C19 polymorphism is associated with reduced responsiveness to clopidogrel and poor clinical outcome after drug-eluting stent (DES) implantation, but its contribution to lesion outcome after DES implantation is unclear. Methods and Results: The study included 160 Japanese patients who received clopidogrel and underwent DES implantation with follow-up angiography. Patients were divided into 3 groups by CYP2C19 polymorphism: extensive metabolizers (EM), intermediate metabolizers (IM), and poor metabolizers (PM). The incidence of major adverse cardiac events (MACE) and target lesion revascularization (TLR) were compared among the 3 groups. Optical coherence tomography (OCT) was performed for 120 patients to ...

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    3. Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Objectives: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease.Background: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acquires images at a resolution of 10 μm, enabling visualization of blood vessel wall microstructure in vivo at an unprecedented level of detail. IVOCT devices are now commercially available worldwide, there is an active user base, and ...

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    4. Ability of Optical Coherence Tomography to Visualize the Entry Port of Spontaneous Coronary Artery Dissection

      Ability of Optical Coherence Tomography to Visualize the Entry Port of Spontaneous Coronary Artery Dissection
      A 51-year-old man was admitted to a local hospital with sudden onset of severe back pain diagnosed as acute type A aortic dissection on contrast computed tomography (CT). The patient was transferred to Kobe University Hospital and underwent total arch replacement. He had no cardiac risk factors except for obesity, and no connective tissue disorders or clinical features of Marfan syndrome. From the intraoperative findings, the entry of the aortic dissection was confirmed to be in the aortic arch without coronary artery ostium involvement. On the fourth day after the
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    5. Optical Coherence Tomography for Patient-specific 3D Artery Reconstruction and Evaluation of Wall Shear Stress in a Left Circumflex Coronary Artery

      Optical Coherence Tomography for Patient-specific 3D Artery Reconstruction and Evaluation of Wall Shear Stress in a Left Circumflex Coronary Artery
      Image-based computational models for quantifying hemodynamic indices in stented coronary arteries often employ biplane angiography and intravascular ultrasound for 3D reconstruction. Recent advances in guidewire simulation algorithms and the rise of optical coherence tomography (OCT) suggest more precise coronary artery reconstruction may be possible. We developed a patient-specific method that combines the superior resolution of OCT with techniques for imaging wire pathway reconstruction adopted from graph theory. The wire pathway with minimum bending energy was determined by applying a shortest path algorithm to a graph representation of the artery based on prior studies indicating a wire adopts the straightest configuration ...
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    6. Ruptured-Plaque-Like Appearance of Restenotic Tissue Following Sirolimus-Eluting Stent Implantation: An Optical Coherence Tomography Case Study

      Ruptured-Plaque-Like Appearance of Restenotic Tissue Following Sirolimus-Eluting Stent Implantation: An Optical Coherence Tomography Case Study
      A 57-year-old man was admitted for exertional angina pectoris. Coronary angiography showed a 99% stenosis in the left circumflex artery. A sirolimus-eluting stent was deployed in the culprit lesion and excellent angiographic results were obtained. Six-month routine follow-up coronary angiography showed a 90% focal restenosis at the proximal edge of the stent. At this site, optical coherence tomography imaging revealed restenotic tissue with a ruptured-plaque-like appearance overlying the stent struts. Also, a low intensity area suggestive of the presence of a lipid core was evident within the neointimal tissue in another cross section.
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    7. Optical coherence evaluation for everolimus-eluting stents at 8 months after implantation

      Optical coherence evaluation for everolimus-eluting stents at 8 months after implantation
      Objective The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients Between November 2008 and October 2009, 25 patients (14 men, 65.5±8.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main Outcome Measures Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To ...
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    8. The Ability of Optical Coherence Tomography to Monitor Percutaneous Coronary Intervention: Detailed Comparison with Intravascular Ultrasound

      The Ability of Optical Coherence Tomography to Monitor Percutaneous Coronary Intervention: Detailed Comparison with Intravascular Ultrasound
      ABSTRACT: Background. We investigated the usefulness of optical coherence tomography (OCT) to evaluate vessel response after stent implantation by comparing with that of intravascular ultrasound (IVUS). Methods and Results. Eighteen cases undergoing percutaneous coronary intervention (PCI) who provided consent for both IVUS and OCT usage pre- and post-PCI procedure were enrolled. The lumen area at the distal site of the culprit lesion was smaller on OCT images than on IVUS images due to proximal vessel occlusion, whereas the lumen area at the proximal site of the lesion did not differ between OCT and IVUS images (distal site: 4.6 ± 2 ...
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    9. Evaluation of stent placement and outcomes with optical coherence tomography

      Evaluation of stent placement and outcomes with optical coherence tomography
      Optical coherence tomography (OCT) is an imaging modality based on fiberoptic technology. OCT imaging systems use optical imaging catheters that emit near-infrared light to produce high resolution, real-time images. The frequencies and bandwidths of infrared light are far higher than medical ultrasound signals, resulting in greatly increased image resolution, which is approximately ten-times higher than that of intravascular ultrasound. Compared with conventional imaging modalities, OCT is superior for the evaluation of vulnerable plaque features, which may be associated with a higher risk of peri-interventional myocardial infarction, such as plaque rupture, thrombus, thin-capped fibroatheroma and macrophages within the fibrous caps. OCT ...
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    10. Comparison by Optical Coherence Tomography of Paclitaxel-Eluting Stents With Sirolimus-Eluting Stents Implanted in One Coronary Artery in One Procedure: 6-Month Follow-up

      Comparison by Optical Coherence Tomography of Paclitaxel-Eluting Stents With Sirolimus-Eluting Stents Implanted in One Coronary Artery in One Procedure: 6-Month Follow-up
      Differences between paclitaxel-eluting stents (PES) and sirolimus-eluting stent (SES) in neointimal proliferation under strictly matched conditions remain to be clarified by optical coherence tomography (OCT). Methods and Results: Between May and December 2007, 27 patients were implanted with a PES and a SES, randomized to either the proximal or distal site in a single coronary artery, and underwent follow-up angiography and OCT examination at 6 months. The frequency of vessel wall apposition with neointima was greater for PES than for SES (92.6% vs 85.8%, P<0.01). The median (25th, 75th percentiles) neointimal thickness (NIT) in PES was ...
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    11. Examination of Accuracy and Factors Influencing Optical Coherence Tomography (OCT) Measurements

      (Article in Japanese) Introduction: Optical coherence tomography (OCT) is a new imaging modality with increasing clinical application. In the present study, we examined the accuracy and factors influencing the OCT measurements (luminal diameter, area, and stent strut thickness).Methods: We evaluated several luminal sizes of phantom model by OCT with several situations (frame-rate: 8.2 or 15.6 F/s; pullback-speed: 1.0 or 2.0 mm/s; position of Image Wire: in-center; off-center) and compared them with the actual value and the intravascular ultrasound measurements. We also evaluated the accuracy of the stent strut thickness (5 bare metal stents ...
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    12. Factors That Influence Measurements and Accurate Evaluation of Stent Apposition by Optical Coherence Tomography

      Factors That Influence Measurements and Accurate Evaluation of Stent Apposition by Optical Coherence Tomography
      kground: Factors influencing measurements and accurate evaluation of stent apposition by optical coherence tomography (OCT) are not established. Methods and Results: Phantom models of known luminal sizes and lengths were evaluated by OCT under various conditions and measurements were compared with actual values. Stents implanted into phantom models were examined by OCT to validate the measurement point on the stent strut surface for accurate evaluation of stent apposition. Strut thickness was measured at 3 points (midpoint, inner and outer surfaces of the stent shadow). The precision of OCT measurements of lumen diameter and area was satisfactory when the image wire ...
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    13. Local Determinants of Thrombus Formation Following Sirolimus-Eluting Stent Implantation Assessed by Optical Coherence Tomography

      Objectives We conducted this study to assess the prevalence and determinants of subclinical thrombus after sirolimus-eluting stent (SES) implantation. Background Angioscopic analyses have demonstrated the presence of thrombus is more common than the clinical incidence of SES thrombosis. Methods Fifty-three patients (53 lesions) underwent 6-month follow-up optical coherence tomography. A stent eccentricity index ([SEI] minimum/maximum stent diameter) was determined in each cross section. To evaluate unevenness of neointimal thickness, a neointimal unevenness score ([NUS] maximum neointimal thickness in the cross section/average neointimal thickness of the same cross section) was calculated for each cross section. Average SEI and NUS ...
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    14. Low plasma adiponectin levels are associated with presence of thin-cap fibroatheroma in men with stable coronary artery disease

      Abstract: Background: Previous studies demonstrated the inverse association of adiponectin with coronary artery disease (CAD) especially in men with acute coronary syndrome, however their association with in vivo plaque vulnerability in stable CAD, which may be reflected by the thin-cap fibroatheroma (TCFA) prevalence, remains unknown.Methods: In 50 men with stable CAD, we identified TCFA with multi-vessel examination of combined use of virtual histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT). The definition of TCFA was described as follows; necrotic-core rich lesion (% necrotic-core >10%) without evidence of an overlying fibrous component and % plaque-volume >40% in at least 3 consecutive ...
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    15. Delayed Neointimalization on Sirolimus-Eluting Stents: 6-Month and 12-Month Follow up by Optical Coherence Tomography

      Background: Sirolimus-eluting stents (SES) have incomplete neointimal coverage at 6-month follow up as determined with optical coherence tomography (OCT). The long-term detailed changes of neointima in SES remains to be clarified. Methods and Results: Serial changes in neointimal coverage of SES from 6 months to 12 months using OCT were examined. Of 21 SES in 13 patients, OCT was used to visualize 2,321 stent struts at 6 months and 2,285 stent struts at 12 months. The frequency of struts without neointimal coverage decreased from 6 months to 12 months (from 10.4 to 5.7%). The frequency of ...
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    16. Low Plasma Adiponectin Level and High Oxidative Stress are Associated with In Vivo Thin-Cap Fibroatheloma Prevalence in Patients with Stable Coronary Artery Disease

      Background; Few studies have investigated the association between biomarkers and in vivo plaque vulnerability in patients with stable coronary artery disease (CAD). Methods; We examined two or three vessels of 55 stable CAD patients with combined use of virtual histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT), and diagnosed thin-cap fibroatheroma (TCFA). The definition of TCFA was described as follow: necrotic core rich lesion (%necrotic-core>10%) without evident overlying fibrous component and %plaque-volume>40% by VH-IVUS analysis, and the thinnest fibrous-cap thickness
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    17. Local Determinants and Clinical Significance of Thrombus Formation Following Sirolimus-Eluting Stent Implantation: Insights from Optical Coherence Tomography Analysis

      Angioscopic analyses have shown the presence of subclinical thrombus in sirolimus-eluting stents (SES) is more common than the clinical incidence of stent thrombosis. However, the determinants and long term significance of subclinical thrombus remain unknown. Thirty five patients (44 stents) who received SES underwent 6 months follow-up optical coherence tomography (OCT). Patients were divided into 2 groups according to the presence of thrombus by OCT. Cross-sectional images were analyzed every 1mm. Stent eccentricity index (SEI; minimum stent diameter divided by maximum stent diameter) was determined in each cross section (CS). To assess the unevenness of neointimal thickness (NIT), a neointimal ...
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    18. Very late thrombosis of sirolimus-eluting stent due to late malapposition: Serial observations with optical coherence tomography

      A 54 years old man underwent directional coronary atherectomy in segment 7 with a partial deep-cut injury. A sirolimus-eluting stent (SES) was implanted at the restenosed post-atherectomy lesion. Six months after SES implantation, intravascular ultrasound (IVUS) examination revealed slight vessel enlargement although there were no malapposed struts. Optical coherence tomography (OCT) revealed partial stent malapposition. Ticlopidine was discontinued 3 months after SES implantation, but aspirin was continued. Twenty-nine months after SES implantation, after discontinuing aspirin for 7 days for colon polypectomy, the patient suffered an acute myocardial infarction at the SES implantation site. IVUS revealed further positive vessel remodeling and ...
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    19. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma

      Aims To evaluate the feasibility of the combined use of virtual histology (VH)-intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for detecting in vivo thin-cap fibroatheroma (TCFA). Methods and results In 56 patients with angina, 126 plaques identified by IVUS findings were analysed using both VH-IVUS and OCT. IVUS-derived TCFA was defined as an abundant necrotic core (>10% of the cross-sectional area) in contact with the lumen (NCCL) and %plaque-volume >40%. OCT-derived TCFA was defined as a fibrous cap thickness of Conclusion Neither modality alone is sufficient for detecting TCFA. The combined use of OCT and VH-IVUS might be ...
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    25-44 of 44 « 1 2
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    1. (42 articles) Junya Shite
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