1. Articles from Joseph N. Mehrabi

    1-6 of 6
    1. Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Background: Topical medications play a large role in the management of cutaneous diseases, but penetration is limited. Device-assisted drug delivery using mechanical destruction, lasers, and other energy-based modalities can increase penetration and absorption through creation of transcutaneous channels. Objective: To examine real-time, in vivo cutaneous changes in response to various devices used to improve topical drug delivery through optical coherence tomography (OCT) imaging. Methods and materials: Treatment was performed with 8 medical devices, including mechanical destruction, lasers, and other energy-based modalities. Optical coherence tomography was used for real-time, noninvasive, in vivo imaging. Results: Using OCT, microneedling and radiofrequency microneedling demonstrated ...

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      Mentions: UC Irvine
    2. Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Introduction: Port-wine birthmarks (PWBs) are congenital capillary malformations that can be located on any area of the body. Vascular features include vessel size, depth, and density, which can greatly differ between patients, individual lesions, and even sites within the same lesion. Previous studies have determined that the location of PWB lesions has impacted their clinical response to laser treatment. Objective: We utilized dynamic optical coherence tomography (D-OCT) to measure in vivo vessel diameter, density, and superficial plexus depth in patients of all ages with PWB on various sites of the body. We hypothesized that these vascular characteristics would differ according ...

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    3. Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Background: Port wine birthmarks (PWB) are congenital capillary malformations. Vessel characteristics, such as diameter and depth, may impact presentation and outcomes. They can be imaged using dynamic optical coherence tomography (D-OCT), a high-resolution, non-invasive imaging method. Purpose: We conducted a cross-sectional observational study to measure in-vivo vascular characteristics as a function of PWB color. Methods: Patients undergoing treatment for PWB were recruited from three sites. PWB were classified by color, and D-OCT images with calculations were obtained. Results: 108 patients were enrolled. Mean age correlated with PWB color, with younger patients having lighter and older patients having darker birthmarks (p ...

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    4. 1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study

      1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study

      Optical coherence tomography (OCT) is a non-invasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7-micron OCT/OCT angiography (OCTA) system that allows for a visualization of both morphology and microvasculature in the deeper layers of the skin. Using this imaging system, we imaged human skin with different benign lesions and described the corresponding features of both structure and ...

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      Mentions: UC Irvine
    5. Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

      Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

      Background and Objective Long‐term benefits can be predicted by the incorporation of more intelligent systems in lasers and other devices. Such systems can produce more reliable zones of thermal injury when used in association with non‐invasive monitoring and precise laser energy delivery. The more classical endpoint of tumor destruction with radiofrequency or long‐pulsed (LP) 1064 nm laser is the non‐specific appearance of tissue graying and tissue contraction. Herein we discuss combining non‐invasive LP 1064 nm Nd:YAG treatment with the assistance of optical coherence tomography (OCT) and the forward‐looking infrared (FLIR) thermal camera while ...

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    6. Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography

      Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography

      Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder of abnormal elastic tissue deposition and calcification. 1 PXE primarily affects the elastic fibers in the dermis of the skin, Bruch membrane of the eye, and the media and intima of mid-sized arteries. The skin findings may present as small yellow, orange, or cream-colored papules, resembling plucked-chicken skin or cobblestone. The skin on the neck and skin flexures may be lax and redundant because of the impaired elastic features, causing a degree of psychosocial distress. Histologic changes of the skin consist of fragmented and disorganized elastin fibers in the mid and deep ...

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      Mentions: UC Irvine
    1-6 of 6
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  2. Topics in the News

    1. (5 articles) UC Irvine
    2. (2 articles) University of Miami
    3. (2 articles) Michelson Diagnostics
    4. (1 articles) Capital Medical University
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    Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography 1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography Microperimetry, Humphrey field analyzer, and optical coherence tomography in detecting glaucoma: a comparative performance study