1. Articles from Luísa S. M. Mendonca

    1-3 of 3
    1. The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

      The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

      Background The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correlation of such changes to the type of MNV have not been conducted. This study aims to determine if different types of MNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on optical coherence tomography angiography (OCTA). Methods Treatment-naïve nAMD patients were retrospectively screened for baseline and follow-up OCTA imaging 10 or more months after initial treatment. Images were graded for MNV type, area, activity, mature versus immature vessels, vessel ...

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    2. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation

      Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation

      Importance Amid an explosion of interest in deep learning in medicine, including within ophthalmology, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges but has not been previously demonstrated in ophthalmology. Objective To determine whether a model-to-data deep learning approach (ie, validation of the algorithm without any data transfer) can be applied in ophthalmology. Design, Setting, and Participants This single-center cross-sectional study included patients with active exudative age-related macular degeneration undergoing optical coherence tomography (OCT) at the New England ...

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    3. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an UHR SD-OCT prototype, with an 850 nm center wavelength and an axial resolution of ~2.7 µm in tissue at a 128kHz A-scan rate. Volumetric cube scans and high-density (HD ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Tufts University
    2. (3 articles) Jay S. Duker
    3. (3 articles) Nadia K. Waheed
    4. (2 articles) Massachusetts Institute of Technology
    5. (2 articles) James G. Fujimoto
    6. (1 articles) Queen's University Belfast
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    Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration Enhanced Intrinsic Skin Aging in Nephropathic Cystinosis Assessed by High-Definition Optical Coherence Tomography Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms Optical Coherence Tomography of Cranial Dura Mater: Microstructural Visualization in Vivo Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy OCT Assistance in Identifying Retinal Breaks in Symptomatic Posterior Vitreous Detachments Optical comparison between micro-CT and OCT in imaging of marginal composite adaptation; Observational study Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study Approaches to quantify optical coherence tomography angiography metrics Optical coherence tomography angiography in glaucoma: analysis of the vessel density-visual field sensitivity relationship