1. Articles from Hongli Yang

    1-20 of 20
    1. OCT Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening versus Bruch’s Membrane Opening Offset

      OCT Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening versus Bruch’s Membrane Opening Offset

      Purpose To measure the magnitude and direction of anterior scleral canal opening (ASCO) offset relative to Bruch’s membrane opening (BMO) (ASCO/BMO offset) in order to characterize neural canal obliqueness and minimum cross-sectional area (NCMCA) in 69 highly myopic and 138 healthy, age-matched, control eyes. Design: Cross-sectional study. Methods Using Optic Coherence Tomography (OCT) scans of the optic nerve head (ONH), BMO and ASCO were manually segmented and their centroids, size and shape were calculated. ASCO/BMO offset magnitude and direction were measured after projecting the ASCO/BMO centroid vector onto the BMO plane. Neural canal axis obliqueness was ...

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    2. OCT Structural Abnormality Detection in Glaucoma using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

      OCT Structural Abnormality Detection in Glaucoma using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

      Purpose To evaluate the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design Retrospective cross-sectional study. Methods 196 GL, 150 GLS eyes and 303 Heathy eyes underwent PRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch’s membrane opening (BMO) and outer pRNFL segmentations. MRW and pRNFLT were quantified in six Garway-Heath (GH) or twelve 30° (clock-hour) sectors. OCT abnormality for each parameter was defined ...

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    3. OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruch’s membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural ...

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    4. Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

      Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

      Purpose : To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods : A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour ...

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    5. Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Purpose To assess glaucoma specialists’ detection of optic nerve head (ONH) rim tissue that is thin by optical coherence tomography (OCT) criteria. Design Reliability analysis Methods 5 clinicians marked the disc margin (DM) and rim margin (RM) on stereo-photos of 151 glaucoma or glaucoma suspect eyes obtained within 3 months of OCT imaging. The photo and OCT infrared image for each eye were colocalized and regionalized into twelve sectors relative to the axis between Bruch’s membrane opening (BMO) centroid and the fovea. For each clinician, the distance from BMO centroid to their DM (DM radius) and RM (RM radius ...

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    6. In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma

      In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma

      Purpose : To compare optical coherence tomography (OCT) detected, optic nerve head (ONH) compliance within control and experimental glaucoma (EG) eyes of 15 monkeys at EG onset. Methods : Intraocular pressure (IOP) was chronically elevated in one eye of each animal using a laser. Experimental glaucoma onset was identified using confocal scanning laser tomography (CSLT). Optical coherence tomography ONH imaging (40 radial B-scans) was performed at 10 mm Hg before and after laser. At EG onset, OCT scans were obtained at IOP 10 and 30 mm Hg. Optical coherence tomography landmarks within the IOP 10/30 images were delineated to quantify IOP ...

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    7. Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma

      Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma

      Purpose : We compare spectral-domain optical coherence tomography (SDOCT) measurements of minimum rim width (MRW), minimum rim area (MRA), and peripapillary retinal nerve fiber layer thickness (RNFLT) to complete orbital optic nerve axon counts in nonhuman primates (NHP) with unilateral experimental glaucoma (EG). Methods : Biweekly SDOCT measurements of MRW, MRA, and RNFLT were acquired under manometric IOP control (10 mm Hg) in 51 NHP during baseline (mean ± SD, 5.0 ± 1.6 sessions) and after laser photocoagulation was applied to the trabecular meshwork of one eye to induce chronic IOP elevation. At the study endpoint (predefined for each NHP), 100% axon ...

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    8. Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Purpose. To characterize age-related differences in the magnitude of Spectral Domain Optical Coherence Tomography (SDOCT) structural change in early experimental glaucoma (EG). Methods. Both eyes from 4 young (1.4 - 2.6 yrs) and 4 old (18.6 - 21.9 yrs) rhesus monkeys were imaged at least 3 times at baseline, and then every 2 weeks following laser-induced, chronic, unilateral IOP elevation until the onset of EG (Confocal Scanning Laser Tomographic surface change confirmed twice). Two to 20 weeks after EG onset, animals were sacrificed and optic nerve axon counts for all eyes were performed. Masked operators delineated retinal and ...

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    9. Anatomic vs. Acquired Image Frame Discordance in Spectral Domain Optical Coherence Tomography Minimum Rim Measurements

      Anatomic vs. Acquired Image Frame Discordance in Spectral Domain Optical Coherence Tomography Minimum Rim Measurements

      Purpose To quantify the effects of using the fovea to Bruch's membrane opening (FoBMO) axis as the nasal-temporal midline for 30° sectoral (clock-hour) spectral domain optical coherence tomography (SDOCT) optic nerve head (ONH) minimum rim width (MRW) and area (MRA) calculations. Methods The internal limiting membrane and BMO were delineated within 24 radial ONH B-scans in 222 eyes of 222 participants with ocular hypertension and glaucoma. For each eye the fovea was marked within the infrared reflectance image, the FoBMO angle (θ) relative to the acquired image frame (AIF) horizontal was calculated, the ONH was divided into 30°sectors using ...

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    10. Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Purpose. To determine if the detection of spectral domain optical coherence tomography (SDOCT) optic nerve head (ONH) change precedes the detection of Confocal Scanning Laser Tomography (CSLT) ONH surface, SDOCT retinal nerve fiber layer (RNFL), Scanning Laser Perimetry (SLP) and multifocal electroretinography (mfERG) change in 8 experimental glaucoma (EG) eyes. Methods. Both eyes from 8 monkeys were tested at least 3 times at baseline, and then every 2 weeks following laser-induced chronic unilateral IOP elevation. Event and trend-based definitions of onset in both the control and EG eyes for a total of 11 SDOCT neural and connective tissue, CSLT surface ...

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    11. Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter

      Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter

      Objective Neuroretinal rim assessment based on the clinical optic disc margin (DM) lacks a sound anatomic basis for 2 reasons: (1) The DM is not reliable as the outer border of rim tissue because of clinically and photographically invisible extensions of Bruch's membrane (BM) inside the DM and (2) nonaccountability of rim tissue orientation in the optic nerve head (ONH). The BM opening-minimum rim width (BMO-MRW) is a parameter that quantifies the rim from its true anatomic outer border, BMO, and accounts for its variable orientation. We report the diagnostic capability of BMO-MRW. Design Case control. Participants Patients with ...

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    12. Influence of Clinically Invisible, but Optical Coherence Tomography Detected, Optic Disc Margin Anatomy on Neuroretinal Rim Evaluation

      Influence of Clinically Invisible, but Optical Coherence Tomography Detected, Optic Disc Margin Anatomy on Neuroretinal Rim Evaluation

      Purpose: We previously demonstrated that most eyes have regionally variable extensions of Bruch's membrane (BM) inside the clinically identified disc margin (DM) that are clinically and photographically invisible. We studied the impact of these findings on DM and BM opening (BMO) derived neuroretinal rim parameters. Methods: Disc stereo-photography and spectral domain optical coherence tomography (SD-OCT, 24 radial B-scans centred on the optic nerve head) were performed on 30 glaucoma patients and 10 age-matched controls. Photographs were co-localized to SD-OCT data such that the DM and BMO could be visualized in each B-scan. Three parameters were computed: (1) DM-horizontal rim ...

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    13. Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging of the Normal and Glaucomatous Nonhuman Primate Optic Nerve Head

      Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging of the Normal and Glaucomatous Nonhuman Primate Optic Nerve Head
      Purpose. To test whether the enhanced depth imaging (EDI) modality improves anterior and posterior lamina cribrosa surface (ALCS and PLCS) visibility compared with conventional spectral-domain optical coherence tomography (SD-OCT). Methods. Conventional and EDI SD-OCT scans were obtained 30 minutes after IOP was manometrically lowered to 10 mm Hg in both eyes of 14 nonhuman primates (NHPs) with unilateral experimental glaucoma (EG). Thirteen horizontal and seven vertical radial B-scans of each SD-OCT data set were delineated by one operator masked to image type. Delineated ALCS and PLCS points were projected to 1 of 100 equal-sized subregions of the neural canal opening ...
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    14. Optic Disc Margin Anatomy in Patients with Glaucoma and Normal Controls with Spectral Domain Optical Coherence Tomography

      Optic Disc Margin Anatomy in Patients with Glaucoma and Normal Controls with Spectral Domain Optical Coherence Tomography

      Objective To characterize optic nerve head (ONH) anatomy related to the clinical optic disc margin with spectral domain-optical coherence tomography (SD-OCT). Design Cross-sectional study. Participants Patients with open-angle glaucoma with focal, diffuse, and sclerotic optic disc damage, and age-matched normal controls. Methods High-resolution radial SD-OCT B-scans centered on the ONH were analyzed at each clock hour. For each scan, the border tissue of Elschnig was classified for obliqueness (internally oblique, externally oblique, or nonoblique) and the presence of Bruch's membrane overhanging the border tissue. Optic disc stereophotographs were co-localized to SD-OCT data with customized software. The frequency with which ...

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    15. Spectral Domain Optical Coherence Tomography (SDOCT) Enhanced Depth Imaging (EDI) of the Normal and Glaucomatous Non-human Primate (NHP) Optic Nerve Head (ONH)

      Spectral Domain Optical Coherence Tomography (SDOCT) Enhanced Depth Imaging (EDI) of the Normal and Glaucomatous Non-human Primate (NHP) Optic Nerve Head (ONH)
      Purpose: To test whether the EDI modality improves anterior and posterior lamina cribrosa surface (ALCS and PLCS) visibility compared to conventional SDOCT. Methods: Conventional and EDI SDOCT scans were obtained 30 minutes after IOP was manometrically lowered to 10 mmHg in both eyes of 14 non-human primates (NHPs) with unilateral experimental glaucoma (EG). Thirteen horizontal and 7 vertical radial B-scans of each SDOCT data set were delineated by one operator masked to image type. Delineated ALCS and PLCS points were projected to one of 100 equal-sized sub-regions of the neural canal opening (NCO) reference plane and the number of delineated ...
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    16. The Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head As Detected by Spectral Domain Optical Coherence Tomography

      The Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head As Detected by Spectral Domain Optical Coherence Tomography
      Purpose To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SDOCT). Methods Five rhesus macaques were tested under isoflurane anaesthesia. SDOCT images of the ONH of both eyes were acquired 30 minutes after IOP was stabilized to 10 mmHg and after 60 minutes to 45 mmHg. The internal limiting membrane, Bruch's Membrane/retinal pigment epithelium, neural canal opening (NCO) and anterior lamina cribrosa surface (ALCS) were delineated using custom software. Differences in SDOCT structural parameters between the two IOP levels were assessed using generalized estimating equations ...
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    17. Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Optic Nerve Head and Peripapillary Retina in Experimental Glaucoma

      Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Optic Nerve Head and Peripapillary Retina in Experimental Glaucoma
      Purpose: To investigate whether longitudinal changes deep within the optic nerve head (ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in experimental glaucoma (EG) and whether these changes are detectable at the onset of Heidelberg Retina Tomography (HRT) defined surface topography depression. Methods: Longitudinal SDOCT imaging (Heidelberg Spectralis) was performed in both eyes of 9 rhesus macaques every 1-3 weeks. One eye of each underwent trabecular laser-induced IOP elevation. Four masked operators delineated internal limiting membrane, retinal nerve fiber layer (RNFL), Bruch's Membrane/retinal pigment epithelium, neural canal opening (NCO) and anterior lamina cribrosa surface (ALCS) using ...
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    18. Comparison of Clinical and Spectral Domain Optical Coherence Tomography Optic Disc Margin Anatomy

      Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) detected optic disc margin anatomy in the monkey eye by co-localizing disc photographs to SD-OCT scans acquired from the same eyes. Methods: The neural canal opening (NCO) was delineated within 40 digital radial sections generated from SD-OCT volumes acquired from 33 normal monkey eyes (15 degrees, 290 x 768 horizontal grid pattern, Heidelberg Spectralis). Each volume was co-localized to its disc photograph by matching the retinal vessels within each photograph to vessel outlines visible within en face SD-OCT images. Border Tissue was delineated where it extended internal to the NCO. A ...
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    19. Comparison of Clinical and Three-Dimensional Histomorphometric Optic Disc Margin Anatomy

      PURPOSE. To investigate the anatomic basis of the optic disc margin in the normal monkey eye by colocalizing optic disc photographs to three-dimensional (3D) histomorphometric reconstructions of the same optic nerve head. METHODS. Optic disc photographs from 28 normal monkey eyes were overlaid onto 3D central retinal vessel reconstructions generated as part of postmortem optic nerve histomorphometric reconstructions for each eye. Within each reconstruction, the Bruch’s membrane opening (BMO) was delineated. Alignment was achieved by matching the clinical vessel outline to the vessel reconstruction with parallel viewing software. An experienced observer viewed stereophotographs and marked the disc margin onto ...
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    20. The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness and retardance

      Purpose: To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT) or retardance. Methods: Nine adult non-human primates were studied under isoflurane anesthesia. Retinal and RNFL thicknesses were measured by spectral domain optical coherence tomography 30 min after IOP was set to 10 mmHg and 60 min after IOP was set to 45 mmHg. RNFL retardance was measured by scanning laser polarimetery in 10 min intervals for 30 min while IOP was 10 mmHg, then for 60 min while IOP was 45 mmHg, then for another 30 min after IOP was returned ...
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    1-20 of 20
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    Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Optic Nerve Head and Peripapillary Retina in Experimental Glaucoma The Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head As Detected by Spectral Domain Optical Coherence Tomography Spectral Domain Optical Coherence Tomography (SDOCT) Enhanced Depth Imaging (EDI) of the Normal and Glaucomatous Non-human Primate (NHP) Optic Nerve Head (ONH) Optic Disc Margin Anatomy in Patients with Glaucoma and Normal Controls with Spectral Domain Optical Coherence Tomography Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging of the Normal and Glaucomatous Nonhuman Primate Optic Nerve Head Influence of Clinically Invisible, but Optical Coherence Tomography Detected, Optic Disc Margin Anatomy on Neuroretinal Rim Evaluation Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma