1. Articles from Kishan Dholakia

    1-12 of 12
    1. Feature Of The Week 08/06/2017: Depth-resolved multimodal imaging: Wavelength modulated spatially offset Raman spectroscopy with OCT

      Feature Of The Week 08/06/2017: Depth-resolved multimodal imaging: Wavelength modulated spatially offset Raman spectroscopy with OCT

      There is now a major drive to obtain complementary information using photonics approaches for biomedical studies. Such multimodality can improve diagnosis and increase the accuracy of determining the sample under investigation. A key advance to address this goal would be to obtain molecular as well as morphological information in a given 3D volume. Optical coherence tomography (OCT) is very powerful and can deliver morphological information at depths of up to millimeters. Raman is an ideal companion as it may deliver molecular information but is typically hampered by its poor penetration into a sample, of only 1/10 of a millimeter ...

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    2. Depth-resolved multimodal imaging: Wavelength Modulated Spatially Offset Raman Spectroscopy with Optical Coherence Tomography

      Depth-resolved multimodal imaging: Wavelength Modulated Spatially Offset Raman Spectroscopy with Optical Coherence Tomography

      A major challenge in biophotonics is multimodal imaging to obtain both morphological and molecular information at depth. We demonstrate a hybrid approach integrating optical coherence tomography (OCT) with wavelength modulated spatially offset Raman spectroscopy (WM-SORS). With depth co-localization obtained from the OCT, we can penetrate 1.2mm deep into the strong scattering media (lard) to acquire up to a 14-fold enhancement of a Raman signal from a hidden target (Polystyrene) with a spatial offset. Our approach is capable of detecting both Raman and OCT signals for pharmaceutical particles embedded in turbid media and revealing the white matter at depth within ...

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    3. Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques

      Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques

      The accurate observation of physiological changes on in vivo samples of important animal species such as Euphausia superba (Antarctic krill) is an important goal in helping to understand how environmental changes can affect animal development. Using a custom made ‘krill trap’, live un-anaesthetized krill were confined for seven hours, during which three hours of optical imaging were obtained and no subsequent ill effects observed. The trap enabled two imaging methods to be employed: optical coherence tomography (OCT) and microscopy. OCT enabled internal structure and tissues to be imaged to a depth of approximately 2 mm and resolution of approximately 12 ...

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    4. Feature Of The Week 11/30/14: Application of OCT to Imaging Subsurface Structure of Antarctic Krill

      Feature Of The Week 11/30/14: Application of OCT to Imaging Subsurface Structure of Antarctic Krill

      Many small open ocean animals, such as Antarctic krill, are an important part of marine ecosystems. To discover what will happen to animals such as krill in a changing ocean, experiments are run in aquaria where conditions can be controlled to simulate water characteristics predicted to occur in the future. The response of individual animals to changing water conditions can be hard to observe, and with current observation techniques it is very difficult to follow the progress of an individual animal through its life. Optical coherence tomography (OCT) is an optical imaging technique that allows images at high resolution to ...

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    5. The Application of Optical Coherence Tomography to Image Subsurface Tissue Structure of Antarctic Krill Euphausia superba

      The Application of Optical Coherence Tomography to Image Subsurface Tissue Structure of Antarctic Krill Euphausia superba

      Many small open ocean animals, such as Antarctic krill, are an important part of marine ecosystems. To discover what will happen to animals such as krill in a changing ocean, experiments are run in aquaria where conditions can be controlled to simulate water characteristics predicted to occur in the future. The response of individual animals to changing water conditions can be hard to observe, and with current observation techniques it is very difficult to follow the progress of an individual animal through its life. Optical coherence tomography (OCT) is an optical imaging technique that allows images at high resolution to ...

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    6. Light sheet imaging the Airy way

      Light sheet imaging the Airy way

      Recent decades have seen an expansion in the breadth of light-based imaging techniques that address problems in biomedicine. Despite perceived limitations in terms of penetration depth and resolution, optical imaging has made significant strides to encroach upon the traditional territory of other modalities, such as electron microscopy and x-ray. At the nanoscale, optical methods exploit light fields in tandem with the properties of fluorescent proteins to answer biological questions in neuroscience and virology that were previously restricted to electron microscopy. At the larger scale, the same methods are making headway to generate biopsies solely with light. A prime example is ...

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    7. Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination

      Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination

      Optical spectroscopy and imaging methods have proved to have potential to discriminate between normal and abnormal tissue types through minimally invasive procedures. Raman spectroscopy and Optical Coherence Tomography (OCT) provides chemical and morphological information of tissues respectively, which are complementary to each other. When used individually they might not be able to obtain high enough sensitivity and specificity that is clinically relevant. In this study we combined Raman spectroscopy information with information obtained from OCT to enhance the sensitivity and specificity in discriminating between Colonic Adenocarcinoma from Normal Colon. OCT being an imaging technique, the information from this technique is ...

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    8. Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer

      Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer

      Raman spectroscopy and Optical Coherence Tomography (OCT) are two optical tools that have shown potential to be used for discriminating between normal and abnormal tissue types. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, in many cases, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. Raman spectroscopy and OCT provides complementary information. While Raman spectroscopy provides information about chemical composition of tissues, OCT provides morphological information of tissues. So combining this complementary information might be able to provide higher diagnostic accuracy that is clinically ...

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    9. Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon

      Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon

      We report a multimodal optical approach using both Raman spectroscopy and optical coherence tomography (OCT) in tandem to discriminate between colonic adenocarcinoma and normal colon. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. We combine the chemical information derived from Raman spectroscopy with the texture parameters extracted from OCT images. The sensitivity obtained using Raman spectroscopy and OCT individually was 89% and 78% respectively and the specificity was 77% and 74% respectively. Combining the information derived ...

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    10. Optical Coherence Tomography

      Optical Coherence Tomography

       An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.

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    11. Tissue surface as the reference arm in Fourier domain optical coherence tomography

      Tissue surface as the reference arm in Fourier domain optical coherence tomography

      We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image ...

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    12. Optical Coherence Tomography

      Optical Coherence Tomography

      An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.

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    1-12 of 12
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    1. (12 articles) University of St. Andrews
    2. (12 articles) Kishan Dholakia
    3. (5 articles) Praveen Cheriyan Ashok
    4. (5 articles) Nicola Bellini
    5. (4 articles) Christian T. A. Brown
    6. (3 articles) Bavishna B. Praveen
    7. (3 articles) Andrew Riches
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    Optical Coherence Tomography Tissue surface as the reference arm in Fourier domain optical coherence tomography Optical Coherence Tomography Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination Light sheet imaging the Airy way The Application of Optical Coherence Tomography to Image Subsurface Tissue Structure of Antarctic Krill Euphausia superba Feature Of The Week 11/30/14: Application of OCT to Imaging Subsurface Structure of Antarctic Krill Feature Of The Week 08/06/2017: Depth-resolved multimodal imaging: Wavelength modulated spatially offset Raman spectroscopy with OCT ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD) Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I