1. Articles from Jianjun Wu

    1-2 of 2
    1. Relationship between elevated plasma ceramides and plaque rupture in patients with ST-segment elevation myocardial infarction

      Relationship between elevated plasma ceramides and plaque rupture in patients with ST-segment elevation myocardial infarction

      Background and aims Ceramides (Cer) is an atherogenic substance. However, the associations between specific plasma Cer levels and culprit plaque morphology in ST-segment elevation myocardial infarction (STEMI) patients are unclear. Methods The study consisted of two parallel cohorts. 100 consecutive patients with STEMI were screened as discovery cohort. In the validation cohort, we separately screened 30 normal donors, 30 stable angina pectoris (SAP) and 315 STEMI patients. All STEMI patients underwent emergency percutaneous intervention (PCI) and optical coherence tomography (OCT) examination for culprit plaque. Based on established diagnostic criteria, STEMI patients were classified into plaque rupture (PR) and plaque erosion ...

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      Mentions: Bo Yu
    2. Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomography

      Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomography

      Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explore the associations between Cer and culprit plaque characterizations evaluated by optical coherence tomography (OCT). It was found that plasma Cer are associated with culprit plaque vulnerability evaluated by OCT, providing evidence supporting proatherogenic roles and potential to act as markers for plaque vulnerability of Cer.

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) Bo Yu
    2. (1 articles) Harbin Medical University
    3. (1 articles) University of Melbourne
    4. (1 articles) Dresden University of Technology
    5. (1 articles) University of Washington
    6. (1 articles) University of Bonn
    7. (1 articles) Ruikang K. Wang
    8. (1 articles) Julia Walther
    9. (1 articles) Frank G. Holz
    10. (1 articles) Edmund Koch
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