1. Articles from supraja murali

    1-8 of 8
    1. Liquid lens enabled optical coherence microscope with Gabor fusion

      Liquid lens enabled optical coherence microscope with Gabor fusion
      A custom optical microscope with an integrated liquid lens to enable an extended depth imaging in biological tissue has been fabricated and shown to provide subcellular resolution using Gabor image fusion in an optical coherence tomography setup. In this paper, we report on the development and assessment path of this technology over the last few years. Specifically, we report on the optical design as well as the MTF prediction and experimental measurements of the new optical microscope head. The microscope head was integrated in a custom optical coherence microscopy setup that is presented. Images of an African frog tadpole, ex ...
      Read Full Article
    2. Assessment of a liquid lens enabled in vivo optical coherence microscope

      Assessment of a liquid lens enabled in vivo optical coherence microscope
      The optical aberrations induced by imaging through skin can be predicted using formulas for Seidel aberrations of a plane-parallel plate. Knowledge of these aberrations helps to guide the choice of numerical aperture (NA) of the optics we can use in an implementation of Gabor domain optical coherence microscopy (GD-OCM), where the focus is the only aberration adjustment made through depth. On this basis, a custom-designed, liquid-lens enabled dynamic focusing optical coherence microscope operating at 0.2 NA is analyzed and validated experimentally. As part of the analysis, we show that the full width at half-maximum metric, as a characteristic descriptor ...
      Read Full Article
    3. Gabor-based fusion technique for Optical Coherence Microscopy

      Gabor-based fusion technique for Optical Coherence Microscopy
      We recently reported on an Optical Coherence Microscopy technique, whose innovation intrinsically builds on a recently reported - 2 μm invariant lateral resolution by design throughout a 2 mm cubic full-field of view - liquid-lens-based dynamic focusing optical probe [Murali et al.,Optics Letters 34, 145-147, 2009]. We shall report in this paper on the image acquisition enabled by this optical probe when combined with an automatic data fusion method developed and described here to produce an in-focus high resolution image throughout the imaging depth of the sample. An African frog tadpole (Xenopus laevis) was imaged with the novel probe and the ...
      Read Full Article
    4. Gabor domain optical coherence microscopy

      Gabor domain optical coherence microscopy
      In this paper, we present a developing technology targeted at clinical imaging, Gabor Domain Optical Coherence Microscopy (GD-OCM), which combines the high resolution imaging of optical coherence microscopy (OCM), high imaging speed of Fourier domain optical coherence tomography (FD-OCT), and invariant lateral resolution of our custom designed dynamic focusing objective. A high lateral resolution optical design of a dynamic-focusing optical probe with no moving parts, which provides an invariant resolution of currently < 3 µm across a 2mm full-field of view and 2mm imaging depth, is presented. Furthermore, an acquisition scheme (using the probe) that is capable of performing automatic real ...
      Read Full Article
    5. Three-dimensional adaptive microscopy using embedded liquid lens

      Three-dimensional adaptive microscopy using embedded liquid lens
      We report on the compact optical design of a high-resolution 3D scanning microscope with adaptive optics capability for refocusing with no moving parts designed for clinical research. The optical aberrations arising from refocusing are compensated for as part of the multiconfiguration optical ... [Opt. Lett. 34, 145-147 (2009)]
      Read Full Article
    6. Gabor domain optical coherence microscopy

      Gabor domain optical coherence microscopy
      Optical Coherence Microscopy (OCM) is an emerging technology capable of depth sectioning of biological tissue at the micrometer scale. In this paper, we propose a developing technology we call Gabor Domain Optical Coherence Microscopy (GD-OCM), whose innovation is two folds: (1) A high lateral resolution optical design of a dynamic-focusing optical probe with no moving parts, which provides an invariant resolution of currently 3 µm across a 2mm full-field of view and 2mm imaging depth by design; (2) An acquisition scheme (using the probe) that is capable of performing automatic data fusion to render an in-focus high resolution image throughout ...
      Read Full Article
    7. Optical design of a dynamic focus catheter for high-resolution endoscopic optical coherence tomography

      Optical design of a dynamic focus catheter for high-resolution endoscopic optical coherence tomography
      The optical system design of a dynamic focus endoscopic probe for optical coherence tomography is reported. The dynamic focus capability is based on a liquid lens technology that provides variable focus by changing its curvatures in response to an electric field variation. The effects of a cylindrical exit window present, in practice, for a catheter were accounted for. Degradation in image quality caused by this window was corrected to get diffraction limited imaging performance. As a result, the dynamically focusing catheter with a lateral resolution ranging from 4 to 6 μm through an ∼5mm imaging distance was designed without mechanically ...
      Read Full Article
    1-8 of 8
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (8 articles) University of Central Florida
    2. (8 articles) Supraja Murali
    3. (8 articles) Jannick P. Rolland
    4. (6 articles) Kevin P. Thompson
    5. (6 articles) Panomsak Meemon
    6. (6 articles) Kye-Sung Lee
    7. (6 articles) Optical Research Associates
    8. (4 articles) University of Rochester
    9. (1 articles) Adrian G. Podoleanu
    10. (1 articles) European Society of Cardiology
    11. (1 articles) Giulio Guagliumi
  3. Popular Articles

  4. Picture Gallery

    Optical design of a dynamic focus catheter for high-resolution endoscopic optical coherence tomography Three-dimensional adaptive microscopy using embedded liquid lens Gabor domain optical coherence microscopy Gabor-based fusion technique for Optical Coherence Microscopy Assessment of a liquid lens enabled in vivo optical coherence microscope Gabor domain optical coherence microscopy Liquid lens enabled optical coherence microscope with Gabor fusion Dynamically focused optical instrument Expert consensus published on use of imaging to guide heart attack treatment Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies ‘Primum non nocere’ aortic dissection involving ostium of right coronary artery diagnosed by optical coherence tomography Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players