1. Articles from john l. keltner

    1-5 of 5
    1. Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Background: Patients with multiple sclerosis (MS) demonstrate thinning of peripapillary retinal nerve fiber layer (RNFL) and decreased macular volume as measured by optical coherence tomography (OCT). To our knowledge, there are no previous reports from a large MS OCT database with strict quality control measures that quantitate RNFL and macula in patients with relapsing-remitting multiple sclerosis. Methods: The University of California Davis OCT Reading Center gathered OCT data at baseline as part of the North American phase 3 trial of fingolimod (Gilenya). Average RNFL thickness (RNFLT) and macular volume (TMV) were measured using time domain OCT (TD-OCT). RNFL quadrants, clock ...

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    2. Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis

      Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis

      Background: To compare the mean central macular thickness (CMT) and the mean average optic nerve retinal nerve fiber layer (RNFL) thickness in the eyes of patients with a history of optic neuritis and/or multiple sclerosis (MS) using 5 commercially available optical coherence tomography (OCT) instruments. Methods: Cross-sectional study including 46 patients (92 eyes) with a history of optic neuritis and/or MS. Both eyes were imaged on the same day with 5 OCT instruments: 1 time-domain OCT (Stratus) and 4 different Fourier-domain (spectral-domain) OCT (3D OCT-1000, Cirrus, RTVue-100, and Spectralis). Results: Twenty-five patients (50 eyes) were included in the ...

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    3. Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging

      Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging
      Aims It is well established that glaucoma results in a thinning of the inner retina. To investigate whether the outer retina is also involved, ultrahigh-resolution retinal imaging techniques were utilised. Methods Eyes from 10 glaucoma patients (25–78 years old), were imaged using three research-grade instruments: (1) ultrahigh-resolution Fourier-domain optical coherence tomography (UHR-FD-OCT), (2) adaptive optics (AO) UHR-FD-OCT and (3) AO-flood illuminated fundus camera (AO-FC). UHR-FD-OCT and AO-UHR-FD-OCT B-scans were examined for any abnormalities in the retinal layers. On some patients, cone density measurements were made from the AO-FC en face images. Correlations between retinal structure and visual sensitivity were ...
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      Mentions: UC Davis
    4. Fourier-Domain Optical Coherence Tomography and Adaptive Optics Reveal Nerve Fiber Layer Loss and Photoreceptor Changes in a Patient With Optic Nerve Drusen.

      June 2008, 28:2 > Fourier-Domain Optical Coherence... ARTICLE LINKS: Fulltext | PDF (822 K) Fourier-Domain Optical Coherence Tomography and Adaptive Optics Reveal Nerve Fiber Layer Loss and Photoreceptor Changes in a Patient With Optic Nerve Drusen. Original Contribution Journal of Neuro-Ophthalmology. 28(2):120-125, June 2008. Choi, Stacey S PhD; Zawadzki, Robert J PhD; Greiner, Mark A MD; Werner, John S PhD; Keltner, John L MD Abstract: Background: New technology allows more precise definit
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    5. Changes in Cellular Structures Revealed by Ultra-high Resolution Retinal Imaging in Optic Neuropathies

      purpose. To study the integrity of inner and outer retinal layers in patients with various types of optic neuropathy by using high-resolution imaging modalities. methods. Three high-resolution imaging systems constructed at the University of California Davis were used to acquire retinal images from patients with optic neuropathy: (1) adaptive optics (AO)-flood–illuminated fundus camera, (2) high-resolution Fourier domain optical coherence tomography (FDOCT), and (3) adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT). The AO fundus camera provides en face images of photoreceptors whereas cross-sectional images (B-scans) of the retina are obtained with both FDOCT and AO-FDOCT. From the volumetric FDOCT ...
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    1-5 of 5
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    Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea Optical coherence tomography image based eye disease detection using deep convolutional neural network Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images Optical coherence tomography assessment of the enamel surface after debonding the ceramic brackets using three different techniques Schizophrenia in Translation: Why the Eye? Advances in OCT Imaging in Myopia and Pathologic Myopia Decision Trees for Glaucoma Screening Based on the Asymmetry of the Retinal Nerve Fiber Layer in Optical Coherence Tomography