1. Articles from Tanmay Deshmukh

    1-7 of 7
    1. The “Virtual Biopsy” of Cancerous Lesions in 3D: Non-Invasive Differentiation between Melanoma and Other Lesions Using Vibrational Optical Coherence Tomography

      The “Virtual Biopsy” of Cancerous Lesions in 3D: Non-Invasive Differentiation between Melanoma and Other Lesions Using Vibrational Optical Coherence Tomography

      Early detection of skin cancer is of critical importance to provide five year survival rates that approach 99%. By 2050, one out of five Americans by age 70 will develop some form of skin cancer. This will result in a projected rate of 50 million skin biopsies per year given the current rate of escalation. In addition, the ability to differentiate between pigmented lesions and melanomas has proven a diagnostic challenge. While dermoscopy and visual analysis are useful in identifying many skin lesions, additional non-invasive techniques are needed to assist in the analysis of difficult to diagnose skin tumors. To ...

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      Mentions: OptoVibronex
    2. Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions?

      Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions?

      Early detection of skin cancer is of critical importance since the five-year survival rate for early detected skin malignancies is 99% but drops to 27% for cancer that has spread to distant lymph nodes and other organs. Over 2.5 million benign skin biopsies (55% of the total) are performed each year in the US at an alarming cost of USD ~2.5 B. Therefore there is an unmet need for novel non-invasive diagnostic approaches to better differentiate between cancerous and non-cancerous lesions, especially in cases when there is a legitimate doubt that a biopsy may be required. The purpose ...

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    3. Use of vibrational optical coherence tomography to measure viscoelastic properties of muscle and tendon: A new method to follow musculoskeletal injury and pathology In vivo

      Use of vibrational optical coherence tomography to measure viscoelastic properties of muscle and tendon: A new method to follow musculoskeletal injury and pathology In vivo

      The biomechanical properties of muscles and tendons in vivo are important parameters needed to understand musculoskeletal physiology and pathology. Values of the shear moduli reported for human musculoskeletal components using elastographic techniques range from several KPa to about 100 KPa and are much lower than the tensile moduli measured in vivo which are reported to be as high as several hundred MPa at high strains. In this paper we report the results of a pilot study to measure the mechanical properties of human muscles and tendons non-invasively and non-destructively in vivo using vibrational optical coherence tomography (VOCT). VOCT is a ...

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    4. Use of Vibrational Optical Coherence Tomography to Analyze the Mechanical Properties of Composite Materials

      Use of Vibrational Optical Coherence Tomography to Analyze the Mechanical Properties of Composite Materials

      Energy storage and dissipation by composite materials are important design parameters for sensors and other devices. While polymeric materials can reversibly store energy by decreased chain randomness (entropic loss) they fail to be able to dissipate energy effectively and ultimately fail due to fatigue and molecular chain breakage. In contrast, composite tissues, such as muscle and tendon complexes, store and dissipate energy through entropic changes in collagen (energy storage) and viscous losses (energy dissipation) by muscle fibers or through fluid flow of the interfibrillar matrix. In this paper we review the molecular basis for energy storage and dissipation by natural ...

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    5. Mechano-Vibrational Spectroscopy of Tissues and Materials Using Vibrational Optical Coherence Tomography: A New Non-Invasive and Non-Destructive Technique

      Mechano-Vibrational Spectroscopy of Tissues and Materials Using Vibrational Optical Coherence Tomography: A New Non-Invasive and Non-Destructive Technique

      Elastic moduli of tissues andsynthetic polymeric materials are important design properties needed to develop new implants. In this paper we report the use of vibrational optical coherence tomography (VOCT) to measure the resonant frequency and calculate the modulus of tissues and synthetic polymers non-invasively and non-destructively in vitro and in vivo . Values of tissue and polymer moduli were obtained by applying an audible sinusoidal sound wave to the surface of each specimen. The sound wave travels to the interior of the material and is reflected back to the surface from underlying layers. A spectrum of resonant frequencies and moduli are ...

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    6. Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Background The modulus and resonant frequency of cancer cells and extracellular matrix are increased in both basal cell and squamous cell carcinomas, and in addition, the collagen stiffness is increased. The organization of the extracellular matrix surrounding cancer cells is clearly different than the extracellular matrix that is seen in normal skin. Materials and Methods We have used vibrational optical coherence tomography (VOCT) to measure the resonant frequency and stiffness of collagen, vascular, and reorganized fibrous extracellular matrix components. Measurements of vessels and fibrotic collagen content made on basal cell carcinomas (BCCs) are compared to similar measurements made on normal ...

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    7. Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      We have used vibrational optical coherence tomography to study the relationship between cellular and collagen mechanical behavior in skin in-vivo. Quantitative measurements of the cellular and collagen resonant frequencies and peak heights were used to calculate the moduli and relative contribution of cells and collagen to the mechanical behavior of skin. Our results suggest that the resonant frequencies measured in vascularized skin are increased by arterial blood flow and is hypothesized to be a result of upregulation of mechanotransduction. The increased cell contribution to the pixel intensity and an increased resonant frequency peak height, suggests that arterial flow influences the ...

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    1-7 of 7
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    Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation? Mechano-Vibrational Spectroscopy of Tissues and Materials Using Vibrational Optical Coherence Tomography: A New Non-Invasive and Non-Destructive Technique Use of Vibrational Optical Coherence Tomography to Analyze the Mechanical Properties of Composite Materials Use of vibrational optical coherence tomography to measure viscoelastic properties of muscle and tendon: A new method to follow musculoskeletal injury and pathology In vivo Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions? The “Virtual Biopsy” of Cancerous Lesions in 3D: Non-Invasive Differentiation between Melanoma and Other Lesions Using Vibrational Optical Coherence Tomography Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea Optical coherence tomography image based eye disease detection using deep convolutional neural network Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images