1. Articles from Tanmay Deshmukh

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    1. Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Background The modulus and resonant frequency of cancer cells and extracellular matrix are increased in both basal cell and squamous cell carcinomas, and in addition, the collagen stiffness is increased. The organization of the extracellular matrix surrounding cancer cells is clearly different than the extracellular matrix that is seen in normal skin. Materials and Methods We have used vibrational optical coherence tomography (VOCT) to measure the resonant frequency and stiffness of collagen, vascular, and reorganized fibrous extracellular matrix components. Measurements of vessels and fibrotic collagen content made on basal cell carcinomas (BCCs) are compared to similar measurements made on normal ...

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    2. Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      We have used vibrational optical coherence tomography to study the relationship between cellular and collagen mechanical behavior in skin in-vivo. Quantitative measurements of the cellular and collagen resonant frequencies and peak heights were used to calculate the moduli and relative contribution of cells and collagen to the mechanical behavior of skin. Our results suggest that the resonant frequencies measured in vascularized skin are increased by arterial blood flow and is hypothesized to be a result of upregulation of mechanotransduction. The increased cell contribution to the pixel intensity and an increased resonant frequency peak height, suggests that arterial flow influences the ...

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    1-2 of 2
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  2. Topics in the News

    1. (1 articles) Academic Medical Center at the University of Amsterdam
    2. (1 articles) Jichi Medical University
    3. (1 articles) University of Milan
    4. (1 articles) Bern University Hospital
    5. (1 articles) Capital Medical University
    6. (1 articles) Nanjing University of Science and Technology
    7. (1 articles) Martin S. Zinkernagel
    8. (1 articles) Junya Ako
    9. (1 articles) Frank D. Verbraak
    10. (1 articles) Giovanni Staurenghi
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