1. Articles from esteban f. carbajal

    1-8 of 8
    1. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear

      Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear

      Phase-sensitive optical coherence tomography (PhOCT) offers exquisite sensitivity to mechanical vibration in biological tissues. There is growing interest in using PhOCT for imaging the nanometer scale vibrations of the ear in animal models of hearing disorders. Swept-source-based systems offer fast acquisition speeds, suppression of common mode noise via balanced detection, and good signal roll-off. However, achieving high phase stability is difficult due to nonlinear laser sweeps and trigger jitter in a typical swept laser source. Here, we report on the initial application of a Vernier-tuned distributed Bragg reflector (VT-DBR) swept laser as the source for a fiber-based PhOCT system. The ...

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    2. Revealing retroperitoneal liposarcoma morphology using optical coherence tomography

      Revealing retroperitoneal liposarcoma morphology using optical coherence tomography
      A new approach to distinguish normal fat, well-differentiated (WD), and dedifferentiated liposarcoma (LS) tumors is demonstrated, based on the use of optical coherence tomography (OCT). OCT images show the same structures seen with conventional histological methods. Our visual grading analysis is supported by numerical analysis of observed structures for normal fat and WDLS samples. Further development could apply the real-time and high resolution advantages of OCT for use in liposarcoma diagnosis and clinical procedures.
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    3. Quantification of microbubbles in blood with phase-sensitive SSOCT

      Quantification of microbubbles in blood with phase-sensitive SSOCT

      We have developed a phase stabilized swept source optical coherence tomography (PhS-SSOCT), that shows an axial resolution of 10 µm, phase sensitivity of 0.04 radians, imaging depth of up to 6 mm in air and a scanning speed of 20 kHz for a single A-line. In this paper, the PhS-SSOCT is applied to quantify gas microbubbles in blood in vitro. The results indicate that the system is able to detect bubbles of diameters greater than 10 µm using the structural image and the microbubbles of diameter less than 10 µm could be detected using the temporal phase response. Images ...

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    4. Enhanced OCT imaging of embryonic tissue with optical clearing

      Enhanced OCT imaging of embryonic tissue with optical clearing
      Optical coherence tomography (OCT) holds great promise as a routine research tool for 3-D analysis of mammalian embryos. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of differen ... [Proc. SPIE 7168, 71682C (2009)] published Fri Feb 20, 2009.
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    5. Concentration effect on the diffusion of glucose in ocular tissues

      In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10−5 cm/s of 10% glucose solution to (5.08±0.23)×10−6 cm/s of 25% glucose solution. The dependence of the permeability on ...
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    6. The effect of solution concentration on diffusion in scleral tissues

      Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui et al. The calculation of permeability coefficient of analytes could potentially be used in a variety of basic science and clinical fields, as well as advanced diagnostic imaging. Before this can occur, a more thorough understanding of the diffusion rate of analytes in biological tissues is needed. For thi ... [Proc. SPIE 6791, 679107 (2008)] published Mon Jun 9, 2008.
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    7. Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera

      Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui et al. Imaging of biological tissues with optical coherence tomography (OCT) poses a great interest for its capability to noninvasively outline subsurface microstructures within tissues. However, a major limitation for many optical imaging techniques is inadequate depth penetration of light in turbid media ... [J. Biomed. Opt. 13, 021110 (2008)] published Mon Apr 21, 2008.
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    8. Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues

      Noninvasive cardiovascular imaging could lead to the early detection and timely treatment of complex atherosclerotic lesions responsible for major cardiovascular events. Recent investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool due to the high resolution this technology achieves in discriminating the different features of atherosclerotic lesions based on structural imaging. We explore the capability of OCT for functional imaging of normal and atherosclerotic aortic tissues based on time- and depth-resolved quantification of the permeability of biomolecules through these tissues. The permeability coefficient of 20% aqueous solution of glucose was found to be (6.80±0 ...
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    1-8 of 8
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  2. Topics in the News

    1. (7 articles) University of Houston
    2. (7 articles) Kirill V. Larin
    3. (5 articles) Saratov State University
    4. (4 articles) Valery V. Tuchin
    5. (4 articles) Mohamad G. Ghosn
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    Enhanced OCT imaging of embryonic tissue with optical clearing Quantification of microbubbles in blood with phase-sensitive SSOCT Revealing retroperitoneal liposarcoma morphology using optical coherence tomography Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo Differentiating untreated and cross-linked porcine corneas of the same measured stiffness with optical coherence elastography Miniaturized endoscopic probe for optical coherence tomography with a tiny magnet driving device Detection and analysis of multi-dimensional pulse wave based on optical coherence tomography Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation Microscale imaging of cilia-driven fluid flow Choroidal thickness measurement by enhanced depth imaging and swept-source optical coherence tomography in central serous chorioretinopathy Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography The EASY-FIT Study