1. Articles from adam m. zysk

    1-11 of 11
    1. Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Purpose . Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Methods . Mastectomy and breast-conserving surgery specimens from 26 women were imaged with a handheld OCT probe. During standard pathology specimen dissection, representative 1-cm × 1-cm tissue regions were grossly identified, assessed with OCT, inked for orientation and ...

      Read Full Article
    2. Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe

      Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe

      Objective To assess the use of a handheld optical coherence tomography (OCT) probe for the evaluation of intraoperative surgical margins during partial nephrectomy (PN). Methods In an initial feasibility study, a radical nephrectomy specimen with a 9-cm tumor was cut into 19 sections, exposing 0 mm (n=8), 1 mm (n=6), and 2 mm (n=5) gross margins. OCT was used to determine the margin width in each specimen. Second, a prospective ex vivo assessment of 15 PN tumor specimens was performed with OCT to determine margin status and to measure the attenuation coefficient (AC) of tumor and renal ...

      Read Full Article
    3. Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      In this Letter, we report the first application of two phase denoising algorithms to Doppler optical coherence tomography (DOCT) velocity maps. When combined with unwrapping algorithms, significantly extended fluid velocity dynamic range is achieved. Instead of the physical upper bound, the fluid velocity dynamic range is now limited by noise level. We show comparisons between physical simulated ideal velocity maps and the experimental results of both algorithms. We demonstrate unwrapped DOCT velocity maps having a peak velocity nearly 10 times the theoretical measurement range.

      Read Full Article
    4. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of tissue microstructure. Previous studies have demonstrated that OCT analysis of excised tissue specimens can distinguish between normal and cancerous tissues by identifying the heterogeneous and disorganized microscopic tissue structures indicative ...

      Read Full Article
    5. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Background A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes. Methods Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric ...

      Read Full Article
    6. Group refractive index reconstruction with broadband interferometric confocal microscopy

      Group refractive index reconstruction with broadband interferometric confocal microscopy

      A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical aperture microscope embedded into an interferometer and a spectrometric means, whereby spectral interferograms are analyzed to compute optical path delay of the beam traversing the sample as the sample is translated through the focus of an interrogating light beam. A determination of group refractive index may serve to disambiguate phase ambiguity in a measurement of refractive index at a specified wavelength. Spatial resolution of object characterization in three dimensions is achieved by imaging the object from ...

      Read Full Article
    7. Method and apparatus for measurement of optical properties in tissue

      Method and apparatus for measurement of optical properties in tissue
      A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.
      Read Full Article
    8. Optical Coherence Tomography: The Intraoperative Assessment of Lymph Nodes in Breast Cancer

      Optical Coherence Tomography: The Intraoperative Assessment of Lymph Nodes in Breast Cancer
      During breast-conserving surgeries, axillary lymph nodes draining from the primary tumor site are removed for disease staging. Although a high number of lymph nodes are often resected during sentinel and lymph-node dissections, only a relatively small percentage of nodes are found to be metastatic, a fact that must be weighed against potential complications such as lymphedema.Without a real-time in vivo or in situ intraoperative imaging tool to provide a microscopic assessment of the nodes, postoperative paraffin section histopathological analysis currently remains the gold standard in assessing the status of lymph nodes. Optical coherence tomography (OCT), a high-resolution real-time microscopic ...
      Read Full Article
    9. Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography

      Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography
      As breast cancer screening rates increase, smaller and more numerous lesions are being identified earlier, leading to more breast-conserving surgical procedures. Achieving a clean surgical margin represents a technical challenge with important clinical implications. Optical coherence tomography (OCT) is introduced as an intraoperative high-resolution imaging technique that assesses surgical breast tumor margins by providing real-time microscopic images up to 2 mm beneath the tissue surface. In a study of 37 patients split between training and study groups, OCT images covering 1 cm2 regions were acquired from surgical margins of lumpectomy specimens, registered with ink, and correlated with corresponding histologic sections ...
      Read Full Article
    10. Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications

      Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk et al. Breast cancer continues to be one of the most widely diagnosed forms of cancer in women and the second leading type of cancer deaths for women. The metastatic spread and staging of breast cancer is typically evaluated through the nodal assessment of the regional lymphatic system, and often this is p ... [Proc. SPIE Int. Soc. Opt. Eng. 6991, 699102 (2008)] published Thu Apr 17, 2008.
      Read Full Article
    11. Optical coherence tomography: a review of clinical development from bench to bedside

      Adam M. Zysk, Freddy T. Nguyen, Amy L. Oldenburg et al. Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging ... [J. Biomed. Opt. 12, 051403 (2007)] published Wed Oct 24, 2007.
      Read Full Article
    1-11 of 11
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (9 articles) University of Illinois at Urbana-Champaign
    2. (9 articles) Stephen A. Boppart
    3. (4 articles) Eric J. Chaney
    4. (3 articles) Steven G. Adie
    5. (2 articles) Andrew Cittadine
    6. (2 articles) P. Scott Carney
    7. (2 articles) Daniel L. Marks
    8. (2 articles) Diagnostic Photonics
    9. (1 articles) Johns Hopkins University
    10. (1 articles) Fredrick A. South
    11. (1 articles) ESPCI ParisTech
    12. (1 articles) Michalina J. Góra
    13. (1 articles) Claude Boccara
    14. (1 articles) Cylite
    15. (1 articles) LLTech
  3. Popular Articles

  4. Picture Gallery

    Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography Optical Coherence Tomography: The Intraoperative Assessment of Lymph Nodes in Breast Cancer Method and apparatus for measurement of optical properties in tissue Group refractive index reconstruction with broadband interferometric confocal microscopy Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies Simon Poole, Cylite co-founder, elected as Fellow of Australian Academy of Science Influence of neoatherosclerosis on prognosis and treatment response in patients with in-stent restenosis Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis