1. Articles from Nikita Kelkar

    1-4 of 4
    1. Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Background The modulus and resonant frequency of cancer cells and extracellular matrix are increased in both basal cell and squamous cell carcinomas, and in addition, the collagen stiffness is increased. The organization of the extracellular matrix surrounding cancer cells is clearly different than the extracellular matrix that is seen in normal skin. Materials and Methods We have used vibrational optical coherence tomography (VOCT) to measure the resonant frequency and stiffness of collagen, vascular, and reorganized fibrous extracellular matrix components. Measurements of vessels and fibrotic collagen content made on basal cell carcinomas (BCCs) are compared to similar measurements made on normal ...

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    2. Comparison of Normal Skin and Thermal and Chemical Burn Wounds using Vibrational Optical Coherence Tomography

      Comparison of Normal Skin and Thermal and Chemical Burn Wounds using Vibrational Optical Coherence Tomography

      he search for methods to evaluate the extent and severity of skin lesions, such as burns and other skin disorders, has been a subject of extentive research. While suction testing, elastography and other tests can be done noninvasively on intact skin, these tests cannot be done on burns and open wounds due to the possible injury that may occur. In addition, they fail to yield comparable results obtained using destructive tests such as uniaxial tensile testing. We have developed a technique to combine optical coherence tomography (OCT) with vibrational analysis (VOCT) to non-invasively and non-destructively evaluate the properties of skin ...

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      Mentions: Lumedica
    3. Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      We have used vibrational optical coherence tomography to study the relationship between cellular and collagen mechanical behavior in skin in-vivo. Quantitative measurements of the cellular and collagen resonant frequencies and peak heights were used to calculate the moduli and relative contribution of cells and collagen to the mechanical behavior of skin. Our results suggest that the resonant frequencies measured in vascularized skin are increased by arterial blood flow and is hypothesized to be a result of upregulation of mechanotransduction. The increased cell contribution to the pixel intensity and an increased resonant frequency peak height, suggests that arterial flow influences the ...

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    4. Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

      Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

      We have used vibrational optical coherence tomography (VOCT) to image and measure the mechanical properties of normal skin and skin lesions. It is observed that in a congenital nevus and normal skin, the cellular epidermis is qualitatively not as bright as in skin lesions including basal cell carcinoma, actinic keratosis and a melanocytic nevus. Melanin and cytochrome c oxidase are reported to attenuate the reflection of near-infrared light at a wavelength of 810 nm and therefore may explain the reduced reflection of light in a congenital nevus and normal skin under conditions where cytochrome c oxidase levels would be expected ...

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    1-4 of 4
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    Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions Comparison of Normal Skin and Thermal and Chemical Burn Wounds using Vibrational Optical Coherence Tomography Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation? Combining Deep Learning With Optical Coherence Tomography Imaging to Determine Scalp Hair and Follicle Counts Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma A NOVEL FINDING OF HYPERREFLECTIVE MATERIAL IN THE SILICONE-RETINA INTERFACE: An Optical Coherence Tomographic and Histopathological Study SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND INDOCYANINE GREEN ANGIOGRAPHY COMPARISONS REVISITED: Using a Novel Deep-Learning-Assisted Approach for Image Registration AUTOMATED RETINAL LAYER SEGMENTATION AND THEIR THICKNESS PROFILES IN HEALTHY SUBJECTS: A Comparison of 55° Wide-field and Conventional 30° Spectral Domain-Optical Coherence Tomography RELATIONSHIP BETWEEN PREOPERATIVE FOVEAL MICROSTRUCTURE AND VISUAL ACUITY IN MACULA-OFF RHEGMATOGENOUS RETINAL DETACHMENT: Imaging Analysis by Swept Source Optical Coherence Tomography Vitreous Seeding in Retinocytoma: Importance of Optical Coherence Tomography Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study