1. Articles from Zachary A. Steelman

    1-5 of 5
    1. Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope

      Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope

      Background and aims: Endoscopic surveillance of Barrett's esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging using a paddle-shaped probe affixed to the endoscope tip. Methods: We integrated Optical Coherence Tomography (OCT), an optical imaging method that produces cross-sectional images, into a paddle probe attached to video endoscope. We acquired images of esophageal epithelium from patients undergoing routine upper GI endoscopy. Images were classified by a reviewer blinded to patient identity and condition, and these results were compared with clinical diagnosis. Results ...

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    2. Deep imaging with 1.3 µm dual-axis optical coherence tomography and an enhanced depth of focus

      Deep imaging with 1.3 µm dual-axis optical coherence tomography and an enhanced depth of focus

      For many clinical applications, such as dermatology, optical coherence tomography (OCT) suffers from limited penetration depth due primarily to the highly scattering nature of biological tissues. Here, we present a novel implementation of dual-axis optical coherence tomography (DA-OCT) that offers improved depth penetration in skin imaging at 1.3 µm compared to conventional OCT. Several unique aspects of DA-OCT are examined here, including the requirements for scattering properties to realize the improvement and the limited depth of focus (DOF) inherent to the technique. To overcome this limitation, our approach uses a tunable lens to coordinate focal plane selection with image ...

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    3. Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe

      Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe

      Significance: The current gold standard for monitoring small intestinal transplant (IT) rejection is endoscopic visual assessment and biopsy of suspicious lesions; however, these lesions are only superficially visualized by endoscopy. Invasive biopsies provide a coarse sampling of tissue health without depicting the true presence and extent of any pathology. Optical coherence tomography (OCT) presents a potential alternative approach with significant advantages over traditional white-light endoscopy. Aim: The aim of our investigation was to evaluate OCT performance in distinguishing clinically relevant morphological features associated with IT graft failure. Approach: OCT was applied to evaluate the small bowel tissues of two rhesus ...

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    4. Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      There exists an unmet need for an optical coherence tomography (OCT) delivery scheme that is simple, robust, and applicable to general surgical applications. To deliver the beam in a narrow form factor, optical borescopes present an attractive potential solution. We present a method for enabling endoscopic delivery of OCT using a handheld rigid borescope adapted to a low-cost OCT engine. The system reduces the distal profile of the scanner, enabling application of the system in otherwise hard-to-access regions. The clinical potential of this design is demonstrated through real-time quantification of articular cartilage thickness, a primary biomarker of joint health during ...

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      Mentions: Duke University
    5. Light-scattering methods for tissue diagnosis

      Light-scattering methods for tissue diagnosis

      Light scattering has become a common biomedical research tool, enabling diagnostic sensitivity to myriad tissue alterations associated with disease. Light–tissue interactions are particularly attractive for diagnostics due to the variety of contrast mechanisms that can be used, including spectral, angle-resolved, and Fourier-domain detection. Photonic diagnostic tools offer further benefits in that they are non-ionizing, non-invasive, and give real-time feedback. In this review, we summarize recent innovations in light-scattering technologies, with a focus on clinical achievements over the previous ten years.

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      Mentions: Duke University
    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Duke University
    2. (1 articles) University of North Carolina
    3. (1 articles) Emory University
    4. (1 articles) Lumedica
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    Light-scattering methods for tissue diagnosis Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe Deep imaging with 1.3 µm dual-axis optical coherence tomography and an enhanced depth of focus Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer