1. Articles from Boris Khlebtsov

    1-2 of 2
    1. Photodynamic opening of the blood-brain barrier and pathways of brain clearing

      Photodynamic opening of the blood-brain barrier and pathways of brain clearing

      A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate two pathways for the brain clearing: 1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal lymphatic system in the subdural space; 2) using optical coherence tomography and intra-parenchymal injection of gold nanorods we observed their clearance through the exit gate of cerebral spinal fluid from ...

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    2. Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study

      Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study
      The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In vivo measurements are performed on pig skin, where nanoparticle suspension drops have been applied. The identification of skin layers is performed by comparison with corresponding histology images. Experimental results exhibit an increase in contrast of the obtained OCT images after a single nanoparticles application. Multiple applications do not lead to increase in the ...
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    1-2 of 2
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  2. Topics in the News

    1. (6 articles) National Institutes of Health
    2. (3 articles) Center for Ophthalmic Optics and Lasers
    3. (3 articles) Oregon Health & Science University
    4. (3 articles) David Huang
    5. (2 articles) Harvard University
    6. (2 articles) Massachusetts General Hospital
    7. (2 articles) University of Southern California
    8. (2 articles) Brett E. Bouma
    9. (2 articles) Johannes F. de Boer
    10. (2 articles) Mohamed Abou Shousha
    11. (1 articles) Institute of Applied Physics
    12. (1 articles) Saratov State University
    13. (1 articles) Nizhny Novgorod State Medical Academy
    14. (1 articles) Mikhail Y. Kirillin
    15. (1 articles) Valery V. Tuchin
    16. (1 articles) Elena V. Zagaynova
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