1. Articles from Elena Zagaynova

    1-7 of 7
    1. Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      This work is dedicated to the development of the OCT system with angiography for everyday clinical use. Two major problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (eg, respiratory and cardiac motions) and online visualization of vessel cross‐sections to provide feedback for the system operator.

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    2. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using “ground truth” OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with fluorescence imaging of tumors expressing genetically encoded fluorescent protein KillerRed that clearly delineates tumor borders. Since the resultant 3D tumor/normal structural maps are inherently co-registered with OCT derived maps ...

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    3. Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

      Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

      Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is ...

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    4. Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers

      Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers

      The combined use of fluorescence cystoscopy and cross-polarization optical coherence tomography (CP OCT) with quantitative estimation of the OCT signal was assessed in 92 bladder zones. It demonstrated the diagnostic accuracy in detecting superficial bladder cancer of 93.6%, sensitivity 96.4%, specificity 92.1%, positive predictive value 87% and negative predictive value 97.9%. Quantitative estimation of OCT signal standard deviation in cross-polarization (CP OCT SD index) makes the visual criteria of CP OCT image assessment more objective. The level of CP OCT SD index for diagnosing superficial bladder cancer, including cancer in situ, was 4.32 dB and ...

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    5. Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study

      Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study
      The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolarization simultaneously. 116 patients with localized flat suspicious lesions in the bladder were enrolled, 360 CP OCT images were obtained and analyzed. CP OCT demonstrated sensitivity 93.7% (vs. 81.2%, <0.0001), specificity 84% (vs. 70.0%, <0.001) and accuracy 85.3% (vs. 71.5%, <0.001) in detecting flat malignant bladder lesions, which is significantly better ...
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    6. Monitoring oncological surgery using optical coherence tomography

      Monitoring oncological surgery using optical coherence tomography
      Detailed, real-time imaging allows for adjustment of surgical margins, thus sparing healthy tissue and increasing the likelihood of complete tumor removal. Development of local recurrence is one of the main causes of unsatisfactory long-term recovery prospects following cancer surgery. Determining the adequate balance between radical tumor removal and maximum preservation of the surrounding tissue is therefore very important for cancer management and, subsequently, the patient's quality of life. Rates of recurrence following surgical resection are appreciably high for a number of cancers. Following transurethral resection of bladder tumors (TURBT), they are reported to be as high as 40–80 ...
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    7. Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study

      Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study
      The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In vivo measurements are performed on pig skin, where nanoparticle suspension drops have been applied. The identification of skin layers is performed by comparison with corresponding histology images. Experimental results exhibit an increase in contrast of the obtained OCT images after a single nanoparticles application. Multiple applications do not lead to increase in the ...
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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) Nizhny Novgorod State Medical Academy
    2. (7 articles) Elena V. Zagaynova
    3. (6 articles) Natalia D. Gladkova
    4. (5 articles) Institute of Applied Physics
    5. (5 articles) Elena B. Kiseleva
    6. (4 articles) Grigory V. Gelikonov
    7. (4 articles) Valentin M. Gelikonov
    8. (3 articles) University of Toronto
    9. (3 articles) Olga S. Streltsova
    10. (3 articles) I. Alex Vitkin
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    Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study Monitoring oncological surgery using optical coherence tomography Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use An air of optimism takes hold for CF sufferers Optical coherence tomography for dynamic axial correction of an optical end-effector for robot-guided surgical laser ablation Optical Coherence Tomography Angiography to Assess Vascular Remodeling of the Choriocapillaris After Low-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy Automatic Classification of Retinal Optical Coherence Tomography Images With Layer Guided Convolutional Neural Network Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity