1. Articles from Michele L. Hooper

    1-2 of 2
    1. Colocalization of optical coherence tomography angiography with histology in the mouse retina

      Colocalization of optical coherence tomography angiography with histology in the mouse retina

      Optical coherence tomography angiography (OCT-A) allows in vivo , non-invasive, functional imaging of retinal perfusion. The purpose of this study was to determine the reliability of OCT-A in visualizing the complete retinal vasculature by comparing in vivo OCT-A images to matched ex vivo tissue in mice. Adult female C57BL/6 mice were imaged to obtain OCT-A images of the superficial vascular complex, intermediate capillary plexus and deep capillary plexus. Z-stack fluorescence images of whole-mounted retinas, labeled for vascular endothelial cells by anti-isolectin immunohistochemistry and FITC-dextran perfusion, were generated. The OCT-A and fluorescence images were manually colocalized and vessel length measured for ...

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    2. Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

      Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

      Purpose : We implemented optical coherence tomography angiography (OCT-A) in mice to: (1) develop quantitative parameters from OCT-A images, (2) measure the reproducibility of the parameters, and (3) determine the impact of experimental models of inner and outer retinal damage on OCT-A findings. Methods : OCT-A images were acquired with a customized system (Spectralis Multiline OCT2). To assess reproducibility, imaging was performed five times over 1 month. Inner retinal damage was induced with optic nerve transection, crush, or intravitreal N -methyl-d-aspartic acid injection in transgenic mice with fluorescently labeled retinal ganglion cells (RGCs). Light-induced retinal damage was induced in albino mice. Mice ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) Dalhousie University
    2. (1 articles) Sun Yat-Sen University
    3. (1 articles) Vanderbilt University
    4. (1 articles) Yale University
    5. (1 articles) Cleveland Clinic
    6. (1 articles) Northwestern University
    7. (1 articles) University of North Carolina
    8. (1 articles) Carl Zeiss Meditec
    9. (1 articles) Alcon
    10. (1 articles) Audioptics Medical
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