1. Articles from Corey A. Smith

    1-3 of 3
    1. Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects

      Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects

      Background/aims Quantitative analysis of optical coherence tomography angiography (OCT-A) images requires a reproducible approach that accounts for sectoral loss. The objective of this study was to determine whether an index that accounts for both global (perfusion density, PD) and asymmetric loss of perfusion, rather than PD alone, more reliably measures loss of perfusion in patients with glaucoma. Methods We analysed macular OCT-A scans of 95 glaucoma patients and 59 control subjects. Two-dimensional projection images corresponding to the superficial vascular plexus were exported and analyses performed to calculate global PD and image asymmetry. An unsigned perfusion asymmetry index (PAI) that ...

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    2. Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

      Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

      Purpose : We implemented optical coherence tomography angiography (OCT-A) in mice to: (1) develop quantitative parameters from OCT-A images, (2) measure the reproducibility of the parameters, and (3) determine the impact of experimental models of inner and outer retinal damage on OCT-A findings. Methods : OCT-A images were acquired with a customized system (Spectralis Multiline OCT2). To assess reproducibility, imaging was performed five times over 1 month. Inner retinal damage was induced with optic nerve transection, crush, or intravitreal N -methyl-d-aspartic acid injection in transgenic mice with fluorescently labeled retinal ganglion cells (RGCs). Light-induced retinal damage was induced in albino mice. Mice ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Dalhousie University
    2. (3 articles) Balwantray C. Chauhan
    3. (2 articles) Glen P. Sharpe
    4. (2 articles) Marcelo T. Nicolela
    5. (1 articles) University of Toronto
    6. (1 articles) University of Sydney
    7. (1 articles) University of Zurich
    8. (1 articles) UCSD
    9. (1 articles) University of Pittsburgh
    10. (1 articles) L V Prasad Eye Institute
    11. (1 articles) Giuseppe Querques
    12. (1 articles) Carl Zeiss Meditec
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