1. Articles from Ryan D. Sochol

    1-2 of 2
    1. Direct laser writing of a titanium dioxide-laden retinal cone phantom for adaptive optics-optical coherence tomography

      Direct laser writing of a titanium dioxide-laden retinal cone phantom for adaptive optics-optical coherence tomography

      The spatial resolution of adaptive optics-optical coherence tomography (AO-OCT) enables visualization of retinal components ( e.g ., photoreceptors), which can advance clinical diagnosis of ocular diseases. Currently, however, variability in AO-OCT system performance suggests a need for standardized physical models, or “phantoms”, that replicate the opto-structural properties of retinal components. Here we employ direct laser writing – a two-photon polymerization-based additive manufacturing technology – using a light scattering titanium (IV) dioxide nanoparticle-laden photomaterial to create novel retinal cone outer segment (OS) phantoms. Fabrication results demonstrate effective mimicry of cone OS diameter and spacing at four retinal eccentricities, while AO-OCT experiments demonstrate cone spacings ...

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    2. 3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems

      3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems

      With adaptive optics (AO), optical coherence tomography and scanning laser ophthalmoscopy imaging systems can resolve individual photoreceptor cells in living eyes, due to enhanced lateral spatial resolution. However, no standard test method exists for experimentally quantifying this parameter in ophthalmic AO imagers. Here, we present three-dimensional (3-D) printed phantoms, which enable the measurement of lateral resolution in an anatomically relevant manner. We used two-photon polymerization to fabricate two phantoms, which mimic the mosaic of cone photoreceptor outer segments at multiple retinal eccentricities. With these phantoms, we demonstrated that the resolution of two multimodal AO systems is similar to theoretical predictions ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) FDA
    2. (2 articles) University of Maryland
    3. (1 articles) National Institutes of Health
    4. (1 articles) Zhuolin Liu
    5. (1 articles) Anant Agrawal
    6. (1 articles) Daniel X. Hammer
    7. (1 articles) Medical University of Vienna
    8. (1 articles) Harbin Medical University
    9. (1 articles) Kawasaki Medical School
    10. (1 articles) Stefan G. Sacu
    11. (1 articles) Hector M. Garcia-Garcia
    12. (1 articles) Bo Yu
    13. (1 articles) Ursula Schmidt-Erfurth
    14. (1 articles) Ron Waksman
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