1. Articles from Max L. Olender

    1-4 of 4
    1. Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions

      Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions

      Atherosclerosis is a complex disease altering vasculature morphology, and subsequently flow, with progressive plaque formation, mural disruption, and lumen occlusion. Determination of clinically-relevant plaque components—particularly calcium, lipid, and fibrous tissue—has driven automated image-based tissue characterization. Atherosclerotic tissue of mixed composition type arises when these principal components interdigitate and combine during the course of progressive atherosclerosis. Nevertheless, such mixed plaque is treated non-uniformly, and often neglected, as a distinct class in image analysis. We therefore quantitatively investigate frameworks to characterize mixed and other plaque tissue types, and examine their implications. Convolutional neural networks operated on labeled intravascular optical coherence ...

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    2. An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging

      An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging

      The increasing prevalence of finite element (FE) simulations in the study of atherosclerosis has spawned numerous inverse FE methods for the mechanical characterization of diseased tissue in vivo. Current approaches are however limited to either homogenized or simplified material representations. This paper presents a novel method to account for tissue heterogeneity and material nonlinearity in the recovery of constitutive behavior using imaging data acquired at differing intravascular pressures by incorporating interfaces between various intra-plaque tissue types into the objective function definition. Method verification was performed in silico by recovering assigned material parameters from a pair of vessel geometries: one derived ...

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    3. A platform for high-fidelity patient-specific structural modelling of atherosclerotic arteries: from intravascular imaging to three-dimensional stress distributions

      A platform for high-fidelity patient-specific structural modelling of atherosclerotic arteries: from intravascular imaging to three-dimensional stress distributions

      The pathophysiology of atherosclerotic lesions, including plaque rupture triggered by mechanical failure of the vessel wall, depends directly on the plaque morphology-modulated mechanical response. The complex interplay between lesion morphology and structural behaviour can be studied with high-fidelity computational modelling. However, construction of three-dimensional (3D) and heterogeneous models is challenging, with most previous work focusing on two-dimensional geometries or on single-material lesion compositions. Addressing these limitations, we here present a semi-automatic computational platform, leveraging clinical optical coherence tomography images to effectively reconstruct a 3D patient-specific multi-material model of atherosclerotic plaques, for which the mechanical response is obtained by structural finite-element ...

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    4. A Mechanical Approach for Smooth Surface Fitting to Delineate Vessel Walls in Optical Coherence Tomography Images

      A Mechanical Approach for Smooth Surface Fitting to Delineate Vessel Walls in Optical Coherence Tomography Images

      Automated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border of the vessel due to limited penetration depth. Existing interpolation and surface fitting methods prove insufficient to accurately fill the gaps between the irregularly-spaced and sometimes unreliably-identified visible segments of the vessel outer border. This paper describes an intuitive, efficient, and flexible new method of three-dimensional surface fitting and smoothing suitable for this task. An anisotropic linear-elastic mesh is fit ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Harvard University
    2. (4 articles) Brigham and Women’s Hospital
    3. (4 articles) Massachusetts Institute of Technology
    4. (2 articles) Ecole Polytechnique Fédérale de Lausanne
    5. (1 articles) Cardiovascular Research Foundation
    6. (1 articles) Harvard University
    7. (1 articles) UC Davis
    8. (1 articles) Massachusetts General Hospital
    9. (1 articles) Capital Medical University
    10. (1 articles) UT Southwestern Medical Center
    11. (1 articles) Tianjin University
    12. (1 articles) Oregon Health & Science University
    13. (1 articles) Erasmus University
    14. (1 articles) Screen Life Sciences
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    A Mechanical Approach for Smooth Surface Fitting to Delineate Vessel Walls in Optical Coherence Tomography Images A platform for high-fidelity patient-specific structural modelling of atherosclerotic arteries: from intravascular imaging to three-dimensional stress distributions An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions Macular and choroidal perfusion using optical coherence tomography angiography in type-2 diabetic patients without diabetic retinopathy Short-term evaluation of clear corneal incision after phacoemulsification using anterior segment optical coherence tomography Evaluation of the central vault following implantable phakic contact lens and its correlation to horizontal white to white corneal diameter by anterior segment optical coherence tomography Automatic bifurcation detection utilizing pullback characteristics of bifurcation in intravascular optical coherence tomography An IoT based predictive modeling for Glaucoma detection in optical coherence tomography images using hybrid genetic algorithm The Value of Optical Coherence Tomography Angiography in Pituitary Adenomas Effectiveness of optical coherence tomography angiography (OCT-A) in staging glaucoma Quantitative dynamic cellular imaging based on 3d unwrapped optical coherence phase microscopyoptical coherence phase microscopy (Thesis)