Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

Purpose Compare rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from two OCT devices in a cohort of glaucoma eyes. Methods Design : Longitudinal cohort study. Setting : Tertiary glaucoma clinic. Patients : 68 glaucoma eyes with ≥2 years of follow-up and ≥4 OCT images. Observation Procedures : Macular volume scans from 2 OCT devices were exported, co-registered, and segmented. Global and sectoral GCIPL data from the central 4.8 × 4.0 mm region were extracted. GCIPL rates of change were estimated with linear regression. Permutation analyses were used to control specificity with the ...