All Articles from Joseph Caprioli -Optical Coherence Tomography News

Articles from Joseph Caprioli

1-18 of 18
1. Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices
  
  Explore American Journal of Ophthalmology Jun 4 2021 Ophthalmology
  
  Purpose Compare rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from two OCT devices in a cohort of glaucoma eyes. Methods Design : Longitudinal cohort study. Setting : Tertiary glaucoma clinic. Patients : 68 glaucoma eyes with ≥2 years of follow-up and ≥4 OCT images. Observation Procedures : Macular volume scans from 2 OCT devices were exported, co-registered, and segmented. Global and sectoral GCIPL data from the central 4.8 × 4.0 mm region were extracted. GCIPL rates of change were estimated with linear regression. Permutation analyses were used to control specificity with the ...
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2. Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma
  
  Explore American Journal of Ophthalmology Jan 29 2021 Ophthalmology
  
  Purpose: Test the hypothesis that visual field (VF) progression can be predicted from baseline and longitudinal optical coherence tomography (OCT) structural measures. Design: Prospective cohort study. Methods: 104 eyes (104 patients) with ≥3 years of follow-up and ≥5 VF exams were enrolled. We defined VF progression based on pointwise linear regression on 24-2 VF (≥3 locations with slope ≤–1.0 dB/year and p<0.01). We used elastic net logistic regression (ENR) and machine learning (ML) to predict VF progression with demographics, baseline circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell/inner plexiform layer (GCIPL) thickness and ...
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3. Comparison of Rates of Progression of Macular OCT Measures in Glaucoma
  
  Explore TVST Journal Aug 25 2020 Ophthalmology
  
  Purpose : The purpose of this study was to compare rates of change of various macular thickness measures and evaluate the influence of baseline damage on macular rates of change. Methods : One hundred twelve eyes (112 patients) with ≥ 2 years of follow-up and ≥ 5 macular optical coherence tomography (OCT) images and 10-2 visual field (VF) tests were included. OCT measures of interests were full macular thickness (FMT), ganglion cell complex (GCC), ganglion cell/inner plexiform layer (GCIPL), ganglion cell layer (GCL), and outer retinal layer (ORL) thickness in 3° × 3° superpixels. Rates of change were estimated with linear regression and normalized ...
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  Mentions: UCLA
4. Macular Imaging with Optical Coherence Tomography in Glaucoma
  
  Explore Survey of Ophthalmology Mar 19 2020 Ophthalmology
  
  With the advent of spectral-domain optical coherence tomography (SD-OCT), imaging of the posterior segment of the eye can be carried out rapidly at multiple anatomical locations, including the optic nerve head (ONH), circumpapillary retinal nerve fiber layer (cp-RNFL), and macula. There is now ample evidence to support the role of SD-OCT imaging of the macula for detection of early glaucoma. Macular SD-OCT measurements demonstrate high reproducibility, and evidence on its utility for detection of glaucoma progression is accumulating. We present a comprehensive review of macular SD-OCT imaging emerging as an essential diagnostic tool in glaucoma.
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5. Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters
  
  Explore American Journal of Ophthalmology Jun 24 2019 Ophthalmology
  
  Purpose To test the hypothesis that baseline optical coherence tomography (OCT) measures predict visual field (VF) progression in a cohort of patients with suspected or established glaucoma and compare their performance to semiquantitative optic disc measures. Design Observational cohort study. Methods Setting: Academic institution. Study Population One-hundred seventy-one eyes of 95 patients with good-quality baseline retinal nerve fiber layer (RNFL) and macular OCT images and disc photographs with >2 years of follow-up and ≥5 VFs. Observation Procedures Baseline macular and RNFL OCT measures and cup-to-disc ratio and disc damage likelihood score. Main Outcome Measures Prediction of glaucomatous visual field deterioration ...
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6. OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes
  
  Explore ScienceDirect May 23 2019 Ophthalmology
  
  Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruch’s membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural ...
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  Mentions: Johns Hopkins University Mount Sinai School of Medicine University of Alabama
7. Longitudinal Macular Structure-Function Relationships in Glaucoma and Their Sources of Variability
  
  Explore American Journal of Ophthalmology May 9 2019 Ophthalmology
  
  Purpose 1) Review central structure-function (SF) relationships in glaucoma; 2) compare contributions of within-session and between-session variability to total variability of macular optical coherence tomography (OCT) thickness measurements; and 3) test the hypothesis that longitudinal within-eye variability of central SF relationships is smaller than between-individual variability. Methods We reviewed the pertinent literature on central SF relationships in glaucoma. Thirty-eight eyes (20 normal or glaucoma subjects) had ×3 macular images per session over 3 sessions and superpixels thickness measurements for ganglion cell layer (GCL), ganglion cell/inner plexiform layer (GCIPL), ganglion cell complex (GCC) and full macular thickness (FMT) were exported ...
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  Mentions: UCLA
8. Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study
  
  Explore IOVS Journal Mar 6 2019 Ophthalmology
  
  Purpose : To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods : A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour ...
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  Mentions: Johns Hopkins University Mount Sinai School of Medicine University of Alabama
9. Peripapillary Retinal Nerve Fiber Measurement with Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration
  
  Explore MDPI Open Access Journals Platform Dec 14 2017 Ophthalmology
  
  Purpose: To evaluate the relationship between the peripapillary retinal nerve fiber layer (RNFL) measurements with Spectral-domain Optical Coherence Tomography (OCT) and Age-related macular degeneration (AMD). Methods: Patients >60 years of age without glaucoma or record of intraocular pressure >21 mmHg and no systemic or intraocular diseases or treatment or surgical intervention that affected the RNFL underwent OCT measurement of the RNFL. The severity of AMD was staged with the Clinical Age-Related Maculopathy Staging System. The relationship between RNFL measurements and AMD stages of one eye per patient was analyzed. Results: Eighty-six eyes (46 patients) with AMD and no glaucoma or ...
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  Mentions: UCLA
10. Optic Nerve Head and RNFL Imaging: Comparison of Technologies (Book Chapter)
  
  Explore Home - Springer Jul 13 2016 Ophthalmology , Textbooks
  
  Each optic nerve imaging technology has its unique strengths and weaknesses
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  Mentions: UCLA
11. Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance
  
  Explore iovs.org May 4 2014 Ophthalmology
  
  Purpose: To analyze the influence of ocular magnification on the peripapillary retinal nerve fiber layer (RNFL) thickness measurement and its performance as acquired with spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT measurements from 108 normal eyes (59 subjects) and 72 glaucoma eyes (58 patients) were exported and custom software was used to correct RNFL measurements for ocular magnification. RNFL prediction limits in normal subjects, structure-function relationships, and RNFL performance for detection of glaucoma were compared before and after correction for ocular magnification (Bennett's formula). Association of disc area with cross-sectional RNFL area was explored. Results: The median (interquartile range ...
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  Mentions: David Geffen School of Medicine UCSD UCLA
12. Macular Ganglion Cell/Inner Plexiform Layer Measurements by Spectral Domain Optical Coherence Tomography for Detection of Early Glaucoma and Comparison to Retinal Nerve Fiber Layer Measurements
  
  Explore American Journal of Ophthalmology Oct 2 2013 Ophthalmology
  
  Purpose To evaluate the performance of ganglion cell layer/inner plexiform layer (GCL/IPL) measurements with spectral-domain optical coherence tomography (Cirrus HD-OCT) for detection of early glaucoma and to compare results to retinal nerve fiber layer (RNFL) measurements. Design Cross-sectional prospective diagnostic study. Methods We enrolled 99 subjects, including 59 eyes with glaucoma (47 subjects) (mean deviation >−6.0 dB) and 91 normal eyes (52 subjects). Patients underwent biometry and peripapillary and macular OCT imaging. Performance of the GCL/IPL and RNFL algorithms was evaluated with area under receiver operating characteristic curves (AUC), likelihood ratios, and sensitivities/specificities adjusting for ...
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  Mentions: David Geffen School of Medicine UCLA
13. Measurement of the Optic Disc Vertical Tilt Angle With Spectral-Domain Optical Coherence Tomography and Influencing Factors
  
  Explore American Journal of Ophthalmology Jul 30 2013 Ophthalmology
  
  Purpose To report a novel method for measuring the vertical tilt angle of the optic nerve (ON) head and to investigate the associated factors. Design Cross-sectional diagnostic study. Methods One hundred and twelve normal, glaucomatous, and glaucoma suspect eyes (99 patients) were enrolled in this study. Subjects underwent a full eye examination, biometry, and spectral-domain optical coherence tomography (SDOCT). The vertical tilt angle was measured on high-resolution cross-sectional SDOCT images passing through the ON head and foveal centers using the inner edges of the Bruch membrane opening as the reference plane. The correlation between the vertical tilt angle with the ...
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  Mentions: David Geffen School of Medicine
14. Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy
  
  Explore iovs.org May 11 2012 Ophthalmology
  
  Purpose: To compare optic disc and neuroretinal rim area measurements from spectral-domain optical coherence tomography (SD-OCT) to those from confocal scanning laser ophthalmoscopy. Methods: Seventy-one eyes from 43 normal subjects or suspected/definite glaucoma patients were prospectively enrolled. All subjects had biometry with the IOLMaster and disc/retinal nerve fiber layer (RNFL) imaging with Cirrus SD-OCT (Optic Disc Cube 200x200) and Heidelberg Retina Tomograph (HRT). Keratometry-corrected (K-corrected) HRT measurements and uncorrected Cirrus disc and rim areas and disc measurements corrected for eye magnification with Bennett's formula (AL-corrected) along with 30-degree sectoral rim areas, vertical cup-to-disc ratio (VCDR), and cup ...
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  Mentions: Carl Zeiss Meditec David Geffen School of Medicine UCLA
15. Structure-Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry
  
  Explore iovs.org Mar 30 2012 Ophthalmology
  
  Purpose: To explore structure-function relationships in early glaucoma with spectral-domain optical coherence tomography (SD-OCT) and standard achromatic perimetry. Methods: One hundred thirty-six eyes of 97 patients with suspected or early glaucoma were enrolled from the clinical database at UCLA's Glaucoma Division. All patients had good-quality peripapillary retinal nerve fiber layer (RNFL)/optic disc measurements (Optic Disc Cube 200x200, Cirrus HD-OCT) and a reliable 24-2 SITA-Standard Humphrey visual field (VF) within a 6-month period. Correlations of global and sectoral RNFL thickness and rim area (RA) measurements with corresponding global and regional VF sensitivities (both in logarithmic [dB] and 1/Lambert ...
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  Mentions: Carl Zeiss Meditec David Geffen School of Medicine UCLA
16. Coupled parametric model for estimation of visual field tests based on OCT macular thickness maps, and vice versa, in glaucoma care
  
  Explore ScienceDirect Jul 6 2011 Ophthalmology
  
  The current standard of care for glaucoma patients consists of functional assessment of vision via visual field (VF) testing, which is sensitive but subjective, time-consuming, and often unreliable. A new imaging technology, Fourier domain optical coherence tomography (OCT), is being introduced to assess the structural characteristics of the macula. This new complementary exam is efficient, objective, and reliable. A complex, but consistent, relationship exists between the structural information provided by macular OCT and the functional information gathered by VF maps. We propose a learning-based framework with the ability to estimate the VF map based on OCT macular thickness measurements as ...
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  Mentions: David Geffen School of Medicine Massachusetts Eye and Ear Infirmary
17. Characterization of Retinal Nerve Fiber Layer in Nonglaucomatous Eyes With Tilted Discs
  
  Explore Archives of Ophthalmology Jan 11 2010 Ophthalmology
  
  Clinical assessment of the optic disc and nerve fiber layer (NFL) is an important method to diagnose and monitor the progress of glaucomatous optic neuropathy but is often difficult in eyes with tilted discs.1-3 Clinically, there are 2 orientations of tilting of the optic disc: temporal and inferior1 (Figure 1). Optical coherence tomography (OCT) demonstrates an acceptable diagnostic ability for glaucoma by comparing an individual patient's NFL thickness profile with those in a normative database.4-6 The purpose of this study is to characterize the NFL of nonglaucomatous eyes with tilted discs using OCT.
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  Mentions: David Geffen School of Medicine
18. Concordance of Retinal Nerve Fiber Layer Defects between Fellow Eyes of Glaucoma Patients Measured by Optical Coherence Tomography
  
  Explore American Journal of Ophthalmology Apr 19 2009 Ophthalmology
  
  Purpose: To determine the pattern of agreement of retinal nerve fiber layer (RNFL) defects between fellow eyes of glaucoma patients measured with optical coherence tomography (OCT). Design: Observational, cross-sectional study.Methods: Seventy-seven glaucoma patients (154 eyes) underwent OCT (Stratus) imaging with the fast RNFL thickness protocol in both eyes. RNFL thickness at each location (12 clock-hour sectors and 4 quadrants) was measured. Main outcome measures were correlations between fellow eyes for RNFL thickness and categorical classifications of RNFL thickness. Nonfellow pairs of eyes, matched randomly, were used as controls.Results: Fellow eyes showed significant correlations of RNFL thickness in all ...
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  Mentions: Carl Zeiss Meditec David Geffen School of Medicine
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